FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894847293> ?p ?o ?g. }

• W2894847293 endingPage "3847" @default.
• W2894847293 startingPage "3838" @default.
• W2894847293 abstract "Platinum-derived chemodrugs constitute an active class in cancer therapeutics. Besides being potent against various solid tumors, oxaliplatin has been recognized as the first platinum compound to be approved for the treatment of colorectal cancer. Structurally, oxaliplatin consists of a platinum metal complexed to oxalate and diaminocyclohexane (DACH) and exert its anticancer action by inhibiting DNA replication and transcription. The present study highlights the binding properties of oxaliplatin with calf thymus DNA using spectroscopic methods to comprehend its binding mechanism at molecular level to overcome associated cellular resistance and side effects. Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopic outcomes confirm that oxaliplatin is a covalent binding agent and also provide sequence specificity in DNA molecule. Infrared spectral results further indicate that oxaliplatin alkylates purine nitrogenous bases majorly guanine residues (G) in the major groove via formation of either interstrand or intrastrand guanine–guanine d(GpG) and guanine–adenine d(GpA) (N7 position) crosslinks accompanied with a slight external binding to sugar–phosphate backbone. Again, circular dichroism (CD) spectroscopic results suggest subtle conformational changes in DNA molecule due to its complexation with oxaliplatin and duplex attains an intermediate conformational state, having characteristics of both B- and C-forms. Further, a moderate binding strength of 4.12 ± 0.2 × 104 M−1 for the interaction has been estimated via ultraviolet–visible spectroscopy. The inferences obtained from these investigations are encouraging and can form the basis for further exploration in the field of rational drug development based on platinum compounds possessing preferential binding for nucleic acid with improved competence.Communicated by Ramaswamy H. Sarma" @default.
• W2894847293 created "2018-10-12" @default.
• W2894847293 creator A5045574383 @default.
• W2894847293 creator A5075162620 @default.
• W2894847293 creator A5087279123 @default.
• W2894847293 date "2018-12-05" @default.
• W2894847293 modified "2023-10-16" @default.
• W2894847293 title "Binding of platinum derivative, oxaliplatin to deoxyribonucleic acid: structural insight into antitumor action" @default.
• W2894847293 cites W1974693247 @default.
• W2894847293 cites W1983965827 @default.
• W2894847293 cites W1986018492 @default.
• W2894847293 cites W1986406178 @default.
• W2894847293 cites W1987604182 @default.
• W2894847293 cites W1990038882 @default.
• W2894847293 cites W2006826463 @default.
• W2894847293 cites W2008160239 @default.
• W2894847293 cites W2011033166 @default.
• W2894847293 cites W2014004239 @default.
• W2894847293 cites W2025998034 @default.
• W2894847293 cites W2027310997 @default.
• W2894847293 cites W2027546079 @default.
• W2894847293 cites W2034541418 @default.
• W2894847293 cites W2034783449 @default.
• W2894847293 cites W2038697117 @default.
• W2894847293 cites W2041619240 @default.
• W2894847293 cites W2042190518 @default.
• W2894847293 cites W2057764203 @default.
• W2894847293 cites W2058977958 @default.
• W2894847293 cites W2059528376 @default.
• W2894847293 cites W2065361941 @default.
• W2894847293 cites W2067680455 @default.
• W2894847293 cites W2071548518 @default.
• W2894847293 cites W2074096759 @default.
• W2894847293 cites W2083339221 @default.
• W2894847293 cites W2085633139 @default.
• W2894847293 cites W2088990537 @default.
• W2894847293 cites W2091103707 @default.
• W2894847293 cites W2092380725 @default.
• W2894847293 cites W2098749704 @default.
• W2894847293 cites W2111699871 @default.
• W2894847293 cites W2116609429 @default.
• W2894847293 cites W2125346934 @default.
• W2894847293 cites W2130177169 @default.
• W2894847293 cites W2141037581 @default.
• W2894847293 cites W2163731055 @default.
• W2894847293 cites W2169358424 @default.
• W2894847293 cites W2170802167 @default.
• W2894847293 cites W2252550602 @default.
• W2894847293 cites W2271458134 @default.
• W2894847293 cites W2282989227 @default.
• W2894847293 cites W2312857181 @default.
• W2894847293 cites W2331072277 @default.
• W2894847293 cites W2337304904 @default.
• W2894847293 cites W2500543755 @default.
• W2894847293 cites W2501718441 @default.
• W2894847293 cites W2501873731 @default.
• W2894847293 cites W2565661242 @default.
• W2894847293 cites W2582077019 @default.
• W2894847293 cites W2794889098 @default.
• W2894847293 cites W2906975216 @default.
• W2894847293 cites W4230767300 @default.
• W2894847293 doi "https://doi.org/10.1080/07391102.2018.1531059" @default.
• W2894847293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30282523" @default.
• W2894847293 hasPublicationYear "2018" @default.
• W2894847293 type Work @default.
• W2894847293 sameAs 2894847293 @default.
• W2894847293 citedByCount "10" @default.
• W2894847293 countsByYear W28948472932019 @default.
• W2894847293 countsByYear W28948472932020 @default.
• W2894847293 countsByYear W28948472932021 @default.
• W2894847293 countsByYear W28948472932022 @default.
• W2894847293 crossrefType "journal-article" @default.
• W2894847293 hasAuthorship W2894847293A5045574383 @default.
• W2894847293 hasAuthorship W2894847293A5075162620 @default.
• W2894847293 hasAuthorship W2894847293A5087279123 @default.
• W2894847293 hasConcept C104317684 @default.
• W2894847293 hasConcept C121608353 @default.
• W2894847293 hasConcept C133571119 @default.
• W2894847293 hasConcept C185592680 @default.
• W2894847293 hasConcept C2778301229 @default.
• W2894847293 hasConcept C2780962732 @default.
• W2894847293 hasConcept C512185932 @default.
• W2894847293 hasConcept C526805850 @default.
• W2894847293 hasConcept C54355233 @default.
• W2894847293 hasConcept C552990157 @default.
• W2894847293 hasConcept C55493867 @default.
• W2894847293 hasConcept C71240020 @default.
• W2894847293 hasConcept C86803240 @default.
• W2894847293 hasConceptScore W2894847293C104317684 @default.
• W2894847293 hasConceptScore W2894847293C121608353 @default.
• W2894847293 hasConceptScore W2894847293C133571119 @default.
• W2894847293 hasConceptScore W2894847293C185592680 @default.
• W2894847293 hasConceptScore W2894847293C2778301229 @default.
• W2894847293 hasConceptScore W2894847293C2780962732 @default.
• W2894847293 hasConceptScore W2894847293C512185932 @default.
• W2894847293 hasConceptScore W2894847293C526805850 @default.
• W2894847293 hasConceptScore W2894847293C54355233 @default.
• W2894847293 hasConceptScore W2894847293C552990157 @default.

• next