FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894847776> ?p ?o ?g. }

• W2894847776 abstract "Sudden death is the most common mode of exodus in patients with heart failure and preserved ejection fraction (HFpEF). Cardiosphere-derived cells (CDCs) reduce inflammation and fibrosis in a rat model of HFpEF, improving diastolic function and prolonging survival. We tested the hypothesis that CDCs decrease ventricular arrhythmias (VAs) and thereby possibly contribute to prolonged survival. Dahl salt-sensitive rats were fed a high-salt diet to induce HFpEF. Allogeneic rat CDCs (or phosphate-buffered saline as placebo) were injected in rats with echo-verified HFpEF. CDC-injected HFpEF rats were less prone to VA induction by programmed electrical stimulation. Action potential duration (APD) was shortened, and APD homogeneity was increased by CDC injection. Transient outward potassium current density was upregulated in cardiomyocytes from CDC rats relative to placebo, as were the underlying transcript (Kcnd3) and protein (Kv4.3) levels. Fibrosis was attenuated in CDC-treated hearts, and survival was increased. Sudden death risk also trended down, albeit nonsignificantly. CDC therapy decreased VA in HFpEF rats by shortening APD, improving APD homogeneity, and decreasing fibrosis. Unlike other stem/progenitor cells, which often exacerbate arrhythmias, CDCs reverse electrical remodeling and suppress arrhythmogenesis in HFpEF." @default.
• W2894847776 created "2018-10-12" @default.
• W2894847776 creator A5006408118 @default.
• W2894847776 creator A5008969046 @default.
• W2894847776 creator A5013195713 @default.
• W2894847776 creator A5014169253 @default.
• W2894847776 creator A5016941575 @default.
• W2894847776 creator A5023856220 @default.
• W2894847776 creator A5033383052 @default.
• W2894847776 creator A5038084459 @default.
• W2894847776 creator A5043804660 @default.
• W2894847776 creator A5046381230 @default.
• W2894847776 creator A5050576849 @default.
• W2894847776 creator A5091675757 @default.
• W2894847776 date "2018-10-04" @default.
• W2894847776 modified "2023-10-15" @default.
• W2894847776 title "Reverse electrical remodeling in rats with heart failure and preserved ejection fraction" @default.
• W2894847776 cites W147260919 @default.
• W2894847776 cites W1590018298 @default.
• W2894847776 cites W2018385177 @default.
• W2894847776 cites W2025787384 @default.
• W2894847776 cites W2035945489 @default.
• W2894847776 cites W2043456930 @default.
• W2894847776 cites W2051854169 @default.
• W2894847776 cites W2051968888 @default.
• W2894847776 cites W2057547167 @default.
• W2894847776 cites W2080539468 @default.
• W2894847776 cites W2100454833 @default.
• W2894847776 cites W2100771939 @default.
• W2894847776 cites W2107992067 @default.
• W2894847776 cites W2119340816 @default.
• W2894847776 cites W2126147950 @default.
• W2894847776 cites W2136790664 @default.
• W2894847776 cites W2143756095 @default.
• W2894847776 cites W2161390320 @default.
• W2894847776 cites W2166271064 @default.
• W2894847776 cites W2167646683 @default.
• W2894847776 cites W2169423632 @default.
• W2894847776 cites W2310251639 @default.
• W2894847776 cites W2518573460 @default.
• W2894847776 cites W2527933700 @default.
• W2894847776 cites W2582848829 @default.
• W2894847776 cites W2587206126 @default.
• W2894847776 cites W2596803679 @default.
• W2894847776 cites W2607027560 @default.
• W2894847776 cites W2612219720 @default.
• W2894847776 cites W2762062721 @default.
• W2894847776 cites W2769309750 @default.
• W2894847776 cites W2884120920 @default.
• W2894847776 cites W4211082352 @default.
• W2894847776 cites W4255009698 @default.
• W2894847776 doi "https://doi.org/10.1172/jci.insight.121123" @default.
• W2894847776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6237473" @default.
• W2894847776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30282820" @default.
• W2894847776 hasPublicationYear "2018" @default.
• W2894847776 type Work @default.
• W2894847776 sameAs 2894847776 @default.
• W2894847776 citedByCount "21" @default.
• W2894847776 countsByYear W28948477762019 @default.
• W2894847776 countsByYear W28948477762020 @default.
• W2894847776 countsByYear W28948477762021 @default.
• W2894847776 countsByYear W28948477762022 @default.
• W2894847776 countsByYear W28948477762023 @default.
• W2894847776 crossrefType "journal-article" @default.
• W2894847776 hasAuthorship W2894847776A5006408118 @default.
• W2894847776 hasAuthorship W2894847776A5008969046 @default.
• W2894847776 hasAuthorship W2894847776A5013195713 @default.
• W2894847776 hasAuthorship W2894847776A5014169253 @default.
• W2894847776 hasAuthorship W2894847776A5016941575 @default.
• W2894847776 hasAuthorship W2894847776A5023856220 @default.
• W2894847776 hasAuthorship W2894847776A5033383052 @default.
• W2894847776 hasAuthorship W2894847776A5038084459 @default.
• W2894847776 hasAuthorship W2894847776A5043804660 @default.
• W2894847776 hasAuthorship W2894847776A5046381230 @default.
• W2894847776 hasAuthorship W2894847776A5050576849 @default.
• W2894847776 hasAuthorship W2894847776A5091675757 @default.
• W2894847776 hasBestOaLocation W28948477761 @default.
• W2894847776 hasConcept C104317684 @default.
• W2894847776 hasConcept C126322002 @default.
• W2894847776 hasConcept C127561419 @default.
• W2894847776 hasConcept C134018914 @default.
• W2894847776 hasConcept C164705383 @default.
• W2894847776 hasConcept C185592680 @default.
• W2894847776 hasConcept C2775935837 @default.
• W2894847776 hasConcept C2777099384 @default.
• W2894847776 hasConcept C2777420927 @default.
• W2894847776 hasConcept C2778198053 @default.
• W2894847776 hasConcept C2779537366 @default.
• W2894847776 hasConcept C2780559512 @default.
• W2894847776 hasConcept C2993353509 @default.
• W2894847776 hasConcept C55493867 @default.
• W2894847776 hasConcept C71924100 @default.
• W2894847776 hasConcept C78085059 @default.
• W2894847776 hasConceptScore W2894847776C104317684 @default.
• W2894847776 hasConceptScore W2894847776C126322002 @default.
• W2894847776 hasConceptScore W2894847776C127561419 @default.
• W2894847776 hasConceptScore W2894847776C134018914 @default.
• W2894847776 hasConceptScore W2894847776C164705383 @default.
• W2894847776 hasConceptScore W2894847776C185592680 @default.
• W2894847776 hasConceptScore W2894847776C2775935837 @default.

• next