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• W2894855010 abstract "Introduction: Acute cholangitis is common and potentially life-threatening complication of gallstone disease. Method: 184 patients with benign obstructive jaundice were included. Men - 68 (37 %), women 116 (63 %). The average age was 64,1 + 1,0 years, ranged from 31 to 88. Cardiovascular diseases were the most common comorbidity. All patients underwent surgical treatment. Results: Acute cholangitis diagnosed in 62 (33,7 %) patients. All patients classified according Tokyo Guidelines 2013 - grade I - 53.3 %, II - 41.9 % and III (severe) - 4.8 %. Recovery of bile duct leads to fast normalization of bilirubin levels, but the activity of AST and ALT remains high. Such changes correlate with morphological findins. With increasing in the duration of jaundice from 7 to 30 days, amount of connective tissue increases from 5.05 ± 0.96 to 11.4 ± 1.39, size of hepatocytes decreases from 66.55 ± 2.07 to 59.55 ± 2.15 that lead to increase of parenchyma-to-stroma ratio from 0.37 ± 0.009 to 0.5 ± 0.012 (p < 0.05). Postoperative complications were observed in 16 (15,2%) patients with cholanditis. Grade 1-2 (Clavien-Dindo) - in 13 (12,38 %) patients, Grade 3b - in 3 (2,85 %). Acute pancreatitis and bleeding were the most common complications. E. coli, P. aeruginosa, K. pneumoniae isolated from bile in patients with mild or severe cholangitis. Conclusions: Cholangitis leads to significant changes in peripheral blood, disturbances of the liver function, subcompensation or decompensation of at least one body system occurs in 46.7 % of patients." @default.
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• W2894855010 date "2018-09-01" @default.
• W2894855010 modified "2023-10-16" @default.
• W2894855010 title "Acute cholangitis in patients with obstructive jaundice" @default.
• W2894855010 doi "https://doi.org/10.1016/j.hpb.2018.06.1436" @default.
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