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- W2894858199 abstract "Introduction: Biliary complications (BC) occur in 10.0% to 30.0% of patients after liver transplantation (LT). The aim of the study was to identify risk factors for BC following LT. Methods: The study group comprised 653 patients treated with LT in our Department between 2008 and 2013. The influence of the analyzed variables was determined based on the logistic and Cox proportional hazards regression methods. Cut-off points for analyzed risk factors were determined based on the analysis of receiver operating characteristics (ROC) curves. Incidence of BC was estimated using Kaplan-Meier method. Results: Biliary leak occurred in 28 (4.3%) patients in the postoperative period. The multivariate analysis revealed that the number of transfused packed red blood cells (p=0.003), preoperative gamma-glutamyl-transpeptidase activity (p=0.013) and bilirubin concentration (p=0.003) were independent risk factors. The analysis of the ROC curves showed that the optimal cut-off points for the prediction of biliary leak was intraoperative transfusion ≥8 units of packed red blood cells, pre-operative gamma-glutamyl-transpeptidase activity ≥112 IU/ml and bilirubin concentration ≥3.5 mg/dl. The incidence of anastomotic strictures were 11.2%, 16.1% and 17.2% after one year, three and five years after LT. Multivariate analysis revealed that biliary leak was independent risk factor (p< 0.001). The incidence of nonanastomotic biliary strictures was 9.5% five years after LT. Conclusion: Considering that the biliary leak appears to be the most clinically significant risk factor for anastomotic stricture, actions to reduce this complication should also lead to a reduction in the frequency of anastomotic strictures." @default.
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- W2894858199 date "2018-09-01" @default.
- W2894858199 modified "2023-09-30" @default.
- W2894858199 title "Risk factors for biliary complications after liver transplantation" @default.
- W2894858199 doi "https://doi.org/10.1016/j.hpb.2018.06.147" @default.
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