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- W2894860740 abstract "Temperature stimulus, easy modulation in comparison to other environmental stimuli, makes thermo-responsive nanocarriers popular in the applications of controlled drug release for cancer therapy. In this study, photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive polymeric nanogels consisted of N-isopropylacrylamide and N-(hydroxymethyl)acrylamide. Significant heat was generated from the SCC-containing nanogels under the exposure to 532-nm green laser, and resulted in cell mortality. The thermo-responsive nanogel loaded with 5-FU, an anti-cancer drug, released the drug explosively when exposed to green laser. The combination of hyperthermia and temperature-induced drug release via green laser irradiation greatly enhanced cell mortality to a maximal extent. Such photothermo-responsive nanogel possesses a great potential in anti-cancer treatment." @default.
- W2894860740 created "2018-10-12" @default.
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- W2894860740 date "2018-10-04" @default.
- W2894860740 modified "2023-10-16" @default.
- W2894860740 title "Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy" @default.
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- W2894860740 doi "https://doi.org/10.3390/polym10101098" @default.
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