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- W2894861591 abstract "Abstract To evade mammalian immunity, Trypanosoma brucei switches the variant surface glycoprotein (VSG) expressed on its surface. Key to this reaction are controls exerted to ensure only one of many subtelomeric multigene VSG expression sites are transcribed at a time. DNA repair activities have to date been implicated only in catalysis of VSG switching by recombination, not transcriptional control. However, how VSG switching is signalled to guide the appropriate reaction, or to integrate switching into parasite growth, is unknown. Here we show that loss of ATR, a DNA damage signalling protein kinase, is lethal and causes increased nuclear genome lesions. ATR depletion also causes expression of mixed VSGs on the cell surface, increased transcription of genes from silent expression sites, and altered localisation of RNA Polymerase I and VEX1, factors involved in VSG transcription. The work therefore reveals that VSG expression control is mediated by a nuclear DNA damage signalling factor." @default.
- W2894861591 created "2018-10-12" @default.
- W2894861591 creator A5019794734 @default.
- W2894861591 creator A5024173243 @default.
- W2894861591 creator A5034222857 @default.
- W2894861591 creator A5043965341 @default.
- W2894861591 creator A5047240744 @default.
- W2894861591 creator A5073798712 @default.
- W2894861591 creator A5080766187 @default.
- W2894861591 date "2018-10-04" @default.
- W2894861591 modified "2023-10-18" @default.
- W2894861591 title "The ATR kinase of Trypanosoma brucei links DNA damage signalling and monoallelic control of surface antigen gene expression during antigenic variation" @default.
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