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- W2894862298 abstract "Binders or “granulating agents” are a critical formulation component in wet granulation, ensuring appropriate surface wetting ability to ensure adhesion and cohesion between inter-particulate surfaces in the wet state, as well as excellent plasticity, compactibility and binding ability. Traditionally binder selection has been empirical however advances have been made in mechanistic and quantitative particle engineering and materials science. The purpose of this chapter is to review the physical-chemical properties of the major binders in current pharmaceutical and commercial use, and to provide a practical and logical guide to wet binder selection and use in the context of physical-chemical properties of the substrate and the binder. Recent advances in mechanistic understanding of granulation technology will be discussed in detail, specifically the importance of selecting binders with a focus on surface energetics, wetting, spreadability, and mechanical properties of the system." @default.
- W2894862298 created "2018-10-12" @default.
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- W2894862298 date "2019-01-01" @default.
- W2894862298 modified "2023-10-06" @default.
- W2894862298 title "Binders in Wet Granulation" @default.
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- W2894862298 doi "https://doi.org/10.1016/b978-0-12-810460-6.00010-5" @default.
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