Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894865807> ?p ?o ?g. }
- W2894865807 endingPage "10113" @default.
- W2894865807 startingPage "10102" @default.
- W2894865807 abstract "In the adult brain, the extracellular matrix (ECM) influences recovery after injury, susceptibility to mental disorders, and is in general a strong regulator of neuronal plasticity. The proteoglycan aggrecan is a core component of the condensed ECM structures termed perineuronal nets (PNNs), and the specific role of PNNs on neural plasticity remains elusive. Here, we genetically targeted the Acan gene encoding for aggrecan using a novel animal model. This allowed for conditional and targeted loss of aggrecan in vivo , which ablated the PNN structure and caused a shift in the population of parvalbumin-expressing inhibitory interneurons toward a high plasticity state. Selective deletion of the Acan gene in the visual cortex of male adult mice reinstated juvenile ocular dominance plasticity, which was mechanistically identical to critical period plasticity. Brain-wide targeting improved object recognition memory. SIGNIFICANCE STATEMENT The study provides the first direct evidence of aggrecan as the main functional constituent and orchestrator of perineuronal nets (PNNs), and that loss of PNNs by aggrecan removal induces a permanent state of critical period-like plasticity. Loss of aggrecan ablates the PNN structure, resulting in invoked juvenile plasticity in the visual cortex and enhanced object recognition memory." @default.
- W2894865807 created "2018-10-12" @default.
- W2894865807 creator A5004865064 @default.
- W2894865807 creator A5011085025 @default.
- W2894865807 creator A5011330036 @default.
- W2894865807 creator A5026745144 @default.
- W2894865807 creator A5034403639 @default.
- W2894865807 creator A5051316175 @default.
- W2894865807 creator A5055001344 @default.
- W2894865807 creator A5078178914 @default.
- W2894865807 creator A5085969102 @default.
- W2894865807 date "2018-10-03" @default.
- W2894865807 modified "2023-10-17" @default.
- W2894865807 title "Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity" @default.
- W2894865807 cites W1501527294 @default.
- W2894865807 cites W1761323037 @default.
- W2894865807 cites W1883330555 @default.
- W2894865807 cites W1965513983 @default.
- W2894865807 cites W1979344173 @default.
- W2894865807 cites W2000453869 @default.
- W2894865807 cites W2003726233 @default.
- W2894865807 cites W2007582187 @default.
- W2894865807 cites W2019601077 @default.
- W2894865807 cites W2025806474 @default.
- W2894865807 cites W2027220714 @default.
- W2894865807 cites W2027937017 @default.
- W2894865807 cites W2033004840 @default.
- W2894865807 cites W2036970711 @default.
- W2894865807 cites W2039539900 @default.
- W2894865807 cites W2040502575 @default.
- W2894865807 cites W2045100245 @default.
- W2894865807 cites W2045316454 @default.
- W2894865807 cites W2054505706 @default.
- W2894865807 cites W2059480421 @default.
- W2894865807 cites W2060784568 @default.
- W2894865807 cites W2074562018 @default.
- W2894865807 cites W2078474557 @default.
- W2894865807 cites W2080602594 @default.
- W2894865807 cites W2085544097 @default.
- W2894865807 cites W2091187766 @default.
- W2894865807 cites W2104508398 @default.
- W2894865807 cites W2112406695 @default.
- W2894865807 cites W2126017421 @default.
- W2894865807 cites W2128966898 @default.
- W2894865807 cites W2164765928 @default.
- W2894865807 cites W2168250667 @default.
- W2894865807 cites W2233246773 @default.
- W2894865807 cites W2467652827 @default.
- W2894865807 cites W2553239728 @default.
- W2894865807 cites W2565754955 @default.
- W2894865807 doi "https://doi.org/10.1523/jneurosci.1122-18.2018" @default.
- W2894865807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6596198" @default.
- W2894865807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30282728" @default.
- W2894865807 hasPublicationYear "2018" @default.
- W2894865807 type Work @default.
- W2894865807 sameAs 2894865807 @default.
- W2894865807 citedByCount "111" @default.
- W2894865807 countsByYear W28948658072018 @default.
- W2894865807 countsByYear W28948658072019 @default.
- W2894865807 countsByYear W28948658072020 @default.
- W2894865807 countsByYear W28948658072021 @default.
- W2894865807 countsByYear W28948658072022 @default.
- W2894865807 countsByYear W28948658072023 @default.
- W2894865807 crossrefType "journal-article" @default.
- W2894865807 hasAuthorship W2894865807A5004865064 @default.
- W2894865807 hasAuthorship W2894865807A5011085025 @default.
- W2894865807 hasAuthorship W2894865807A5011330036 @default.
- W2894865807 hasAuthorship W2894865807A5026745144 @default.
- W2894865807 hasAuthorship W2894865807A5034403639 @default.
- W2894865807 hasAuthorship W2894865807A5051316175 @default.
- W2894865807 hasAuthorship W2894865807A5055001344 @default.
- W2894865807 hasAuthorship W2894865807A5078178914 @default.
- W2894865807 hasAuthorship W2894865807A5085969102 @default.
- W2894865807 hasBestOaLocation W28948658071 @default.
- W2894865807 hasConcept C129987498 @default.
- W2894865807 hasConcept C142724271 @default.
- W2894865807 hasConcept C159985019 @default.
- W2894865807 hasConcept C169760540 @default.
- W2894865807 hasConcept C170493617 @default.
- W2894865807 hasConcept C189165786 @default.
- W2894865807 hasConcept C192562407 @default.
- W2894865807 hasConcept C197534660 @default.
- W2894865807 hasConcept C204787440 @default.
- W2894865807 hasConcept C2776164576 @default.
- W2894865807 hasConcept C3020332539 @default.
- W2894865807 hasConcept C47611674 @default.
- W2894865807 hasConcept C54355233 @default.
- W2894865807 hasConcept C71924100 @default.
- W2894865807 hasConcept C79186407 @default.
- W2894865807 hasConcept C86803240 @default.
- W2894865807 hasConcept C95444343 @default.
- W2894865807 hasConcept C98229152 @default.
- W2894865807 hasConceptScore W2894865807C129987498 @default.
- W2894865807 hasConceptScore W2894865807C142724271 @default.
- W2894865807 hasConceptScore W2894865807C159985019 @default.
- W2894865807 hasConceptScore W2894865807C169760540 @default.
- W2894865807 hasConceptScore W2894865807C170493617 @default.
- W2894865807 hasConceptScore W2894865807C189165786 @default.