FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894868475> ?p ?o ?g. }

• W2894868475 abstract "Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Halothane and caffeine induce excessive sarcoplasmic calcium liberation and skeletal muscle contracture in patients susceptible to malignant hyperthermia (MH) and are utilized for diagnosis in the in vitro contracture test. Intramuscular injection previously caused a marked local lactate increase in MH-susceptible but not in MH-nonsusceptible individuals in vivo. Using shear-wave elastography, this study evaluated localized changes in muscle stiffness after intramuscular injection of halothane and caffeine. Methods Microdialysis probes were placed into the gracilis muscle of 16 pigs (9 MH-susceptible and 7 MH-nonsusceptible). After local injection of either halothane or caffeine in different concentrations, changes of tissue elasticity surrounding the probe were examined by quantitative shear-wave elastography. Local lactate concentrations were analyzed spectrophotometrically. Results Ultrasound elastography detected a temporary increase in local muscle rigidity in MH-susceptible but not in MH-nonsusceptible pigs after 2.5 and 5 vol% halothane and after 10, 40, and 80 mM caffeine, whereas there were no differences in the control groups (median [interquartile range] for maximum effect after 5 vol% halothane: MH-susceptible: 97 [31 to 148] vs. MH-nonsusceptible: 5 [−6 to 18] kPa; P = 0.0006; maximum effect after 80 mM caffeine: 112 [64 to 174] vs. −3 [−6 to 35] kPa; P = 0.0002). These effects were seen rapidly within 5 min. Local lactate concentrations were higher in MH-susceptible versus nonsusceptible pigs after 1 and 2.5 vol% halothane and 10, 40, and 80 mM caffeine (2.5 vol% halothane: MH-susceptible: 2.8 [1.9 to 4.4] vs. MH-nonsusceptible: 0.6 [0.6 to 0.7] mmol/l; P &lt; 0.0001; 80 mM caffeine: 5.2 [4.1 to 6.3] vs. 1.6 [1.2 to 2.4] mmol/l; P &lt; 0.0001). After 10 vol% halothane, rigidity and lactate levels were increased in both MH-susceptible and MH-nonsusceptible animals. Conclusions This pilot study revealed shear-wave elastography as a suitable technique for real-time detection of altered tissue elasticity in response to pharmacologic stimulation. By considering the variability of these results, further test protocol optimization is required before elastography could serve as a minimally invasive MH diagnostic test." @default.
• W2894868475 created "2018-10-12" @default.
• W2894868475 creator A5006465844 @default.
• W2894868475 creator A5023018408 @default.
• W2894868475 creator A5040897336 @default.
• W2894868475 creator A5042580353 @default.
• W2894868475 creator A5052186101 @default.
• W2894868475 date "2018-11-01" @default.
• W2894868475 modified "2023-09-25" @default.
• W2894868475 title "Ultrasound Elastography for Rapid, Real-time Detection of Localized Muscular Reaction in Malignant Hyperthermia–susceptible Pigs" @default.
• W2894868475 cites W1782397712 @default.
• W2894868475 cites W1901419121 @default.
• W2894868475 cites W1968820052 @default.
• W2894868475 cites W1972331461 @default.
• W2894868475 cites W2003169423 @default.
• W2894868475 cites W2034044880 @default.
• W2894868475 cites W2050600095 @default.
• W2894868475 cites W2056642787 @default.
• W2894868475 cites W2060035366 @default.
• W2894868475 cites W2072496389 @default.
• W2894868475 cites W2075422831 @default.
• W2894868475 cites W2108616409 @default.
• W2894868475 cites W2110280396 @default.
• W2894868475 cites W2130400238 @default.
• W2894868475 cites W2136669811 @default.
• W2894868475 cites W2142734259 @default.
• W2894868475 cites W2146587884 @default.
• W2894868475 cites W2150815979 @default.
• W2894868475 cites W2151803236 @default.
• W2894868475 cites W2319152554 @default.
• W2894868475 cites W2396440954 @default.
• W2894868475 cites W2472708052 @default.
• W2894868475 cites W2513955266 @default.
• W2894868475 cites W2554318904 @default.
• W2894868475 cites W2565881002 @default.
• W2894868475 cites W4248197639 @default.
• W2894868475 doi "https://doi.org/10.1097/aln.0000000000002424" @default.
• W2894868475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30204593" @default.
• W2894868475 hasPublicationYear "2018" @default.
• W2894868475 type Work @default.
• W2894868475 sameAs 2894868475 @default.
• W2894868475 citedByCount "1" @default.
• W2894868475 countsByYear W28948684752022 @default.
• W2894868475 crossrefType "journal-article" @default.
• W2894868475 hasAuthorship W2894868475A5006465844 @default.
• W2894868475 hasAuthorship W2894868475A5023018408 @default.
• W2894868475 hasAuthorship W2894868475A5040897336 @default.
• W2894868475 hasAuthorship W2894868475A5042580353 @default.
• W2894868475 hasAuthorship W2894868475A5052186101 @default.
• W2894868475 hasConcept C126322002 @default.
• W2894868475 hasConcept C126838900 @default.
• W2894868475 hasConcept C127413603 @default.
• W2894868475 hasConcept C141071460 @default.
• W2894868475 hasConcept C143753070 @default.
• W2894868475 hasConcept C2776291583 @default.
• W2894868475 hasConcept C2776932660 @default.
• W2894868475 hasConcept C2776937108 @default.
• W2894868475 hasConcept C2777690781 @default.
• W2894868475 hasConcept C2778500429 @default.
• W2894868475 hasConcept C2778575482 @default.
• W2894868475 hasConcept C2779372316 @default.
• W2894868475 hasConcept C2993843704 @default.
• W2894868475 hasConcept C42219234 @default.
• W2894868475 hasConcept C66938386 @default.
• W2894868475 hasConcept C71924100 @default.
• W2894868475 hasConceptScore W2894868475C126322002 @default.
• W2894868475 hasConceptScore W2894868475C126838900 @default.
• W2894868475 hasConceptScore W2894868475C127413603 @default.
• W2894868475 hasConceptScore W2894868475C141071460 @default.
• W2894868475 hasConceptScore W2894868475C143753070 @default.
• W2894868475 hasConceptScore W2894868475C2776291583 @default.
• W2894868475 hasConceptScore W2894868475C2776932660 @default.
• W2894868475 hasConceptScore W2894868475C2776937108 @default.
• W2894868475 hasConceptScore W2894868475C2777690781 @default.
• W2894868475 hasConceptScore W2894868475C2778500429 @default.
• W2894868475 hasConceptScore W2894868475C2778575482 @default.
• W2894868475 hasConceptScore W2894868475C2779372316 @default.
• W2894868475 hasConceptScore W2894868475C2993843704 @default.
• W2894868475 hasConceptScore W2894868475C42219234 @default.
• W2894868475 hasConceptScore W2894868475C66938386 @default.
• W2894868475 hasConceptScore W2894868475C71924100 @default.
• W2894868475 hasLocation W28948684751 @default.
• W2894868475 hasLocation W28948684752 @default.
• W2894868475 hasOpenAccess W2894868475 @default.
• W2894868475 hasPrimaryLocation W28948684751 @default.
• W2894868475 hasRelatedWork W2006599866 @default.
• W2894868475 hasRelatedWork W2018507400 @default.
• W2894868475 hasRelatedWork W2051638548 @default.
• W2894868475 hasRelatedWork W2084131895 @default.
• W2894868475 hasRelatedWork W2087218963 @default.
• W2894868475 hasRelatedWork W2153739000 @default.
• W2894868475 hasRelatedWork W2160430268 @default.
• W2894868475 hasRelatedWork W2398930276 @default.
• W2894868475 hasRelatedWork W2894868475 @default.
• W2894868475 hasRelatedWork W149189570 @default.
• W2894868475 isParatext "false" @default.
• W2894868475 isRetracted "false" @default.
• W2894868475 magId "2894868475" @default.
• W2894868475 workType "article" @default.