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- W2894868603 abstract "Like proteins, some RNAs fold to compact structures. We can model functional RNAs as a series of short, rigid, base-paired elements, connected by non-base-paired nucleotides that serve as junctions. These connecting regions bend and twist, facilitating the formation of tertiary contacts that stabilize compact states. Here, we explore the roles of salt and junction sequence in determining the structures of a ubiquitous connector: an asymmetric internal loop. We focus on the J5/5a junction from the widely studied P4–P6 domain of the Tetrahymena ribozyme. Following the addition of magnesium ions to fold P4–P6, this junction bends dramatically, bringing the two halves of the RNA domain together for tertiary contact engagement. Using single-molecule fluorescence resonance energy transfer (smFRET), we examine the role of sequence and salt on model RNA constructs that contain these junction regions. We explore the wild-type J5/5a junction as well as two sequence variants. These junctions display distinct, salt-dependent conformations. Small-angle X-ray scattering (SAXS) measurements verify that these effects persist in the full-length P4–P6 domain. These measurements underscore the importance of junction sequence and interactions with ions in facilitating RNA folding." @default.
- W2894868603 created "2018-10-12" @default.
- W2894868603 creator A5006054489 @default.
- W2894868603 creator A5016954340 @default.
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- W2894868603 date "2018-10-04" @default.
- W2894868603 modified "2023-10-14" @default.
- W2894868603 title "How the Conformations of an Internal Junction Contribute to Fold an RNA Domain" @default.
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- W2894868603 doi "https://doi.org/10.1021/acs.jpcb.8b07262" @default.
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- W2894868603 hasPublicationYear "2018" @default.
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