FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894868652> ?p ?o ?g. }

• W2894868652 endingPage "94" @default.
• W2894868652 startingPage "87" @default.
• W2894868652 abstract "Paeonol is a natural flavonoid isolated from Moutan Cortex, which has been found to exhibit antioxidant, anti-apoptotic, anti-aging and anti-inflammatory bioactivities. Herein, we investigated the nephroprotective efficacy of paeonol against Pb-induced toxicity and elucidated the potential mechanisms. The results revealed that paeonol significantly ameliorated renal dysfunction and histology changes of Pb-treated mice. Paeonol inhibited oxidative stress and increased activities of antioxidant enzyme in the kidneys of Pb-treated mice. Paeonol decreased the nuclear factor-κB activation and over-production of inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Paeonol suppressed endoplasmic reticulum (ER) stress in kidneys of in the Pb treatment group and primary kidney mesangial cells. Moreover, paeonol increased the denosine 5‘-monophosphate-activated protein kinase (AMPK) phosphorylation and decreased the activations of glycogen synthase kinase-3 (GSK-3), protein kinase RNA-like ER kinase (PERK), inositol-requiring protein-1 (IRE1), c-jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK). These results were further confirmed in primary kidney mesangial cells. Taken together, these findings indicate that paeonol could protect kidney form Pb-induced injury by inhibiting oxidative stress, ER stress and inflammation via the AMPK and GSK-3 pathway. Paeonol might be a potential therapeutic agent to inhibit ER stress-associated inflammation in lead-stimulated kidneys." @default.
• W2894868652 created "2018-10-12" @default.
• W2894868652 creator A5007703380 @default.
• W2894868652 creator A5017014383 @default.
• W2894868652 creator A5024577714 @default.
• W2894868652 creator A5027835055 @default.
• W2894868652 creator A5039712648 @default.
• W2894868652 creator A5074770112 @default.
• W2894868652 creator A5076512552 @default.
• W2894868652 creator A5087479827 @default.
• W2894868652 creator A5090541536 @default.
• W2894868652 date "2018-12-01" @default.
• W2894868652 modified "2023-09-25" @default.
• W2894868652 title "Role of AMPK pathway in lead-induced endoplasmic reticulum stress in kidney and in paeonol-induced protection in mice" @default.
• W2894868652 cites W1793903715 @default.
• W2894868652 cites W1847176359 @default.
• W2894868652 cites W1901580941 @default.
• W2894868652 cites W1987897077 @default.
• W2894868652 cites W1989411375 @default.
• W2894868652 cites W2002207827 @default.
• W2894868652 cites W2038974136 @default.
• W2894868652 cites W2048741008 @default.
• W2894868652 cites W2051110479 @default.
• W2894868652 cites W2056821358 @default.
• W2894868652 cites W2057218469 @default.
• W2894868652 cites W2093997522 @default.
• W2894868652 cites W2095218165 @default.
• W2894868652 cites W2153078832 @default.
• W2894868652 cites W2334390238 @default.
• W2894868652 cites W2343961997 @default.
• W2894868652 cites W2415579035 @default.
• W2894868652 cites W2499800184 @default.
• W2894868652 cites W2520563514 @default.
• W2894868652 cites W2538301867 @default.
• W2894868652 cites W2560048061 @default.
• W2894868652 cites W2584233082 @default.
• W2894868652 cites W2588778800 @default.
• W2894868652 cites W2618324532 @default.
• W2894868652 cites W2738968683 @default.
• W2894868652 cites W2767391725 @default.
• W2894868652 cites W2781891708 @default.
• W2894868652 cites W2789092782 @default.
• W2894868652 cites W2790055067 @default.
• W2894868652 doi "https://doi.org/10.1016/j.fct.2018.10.024" @default.
• W2894868652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30296514" @default.
• W2894868652 hasPublicationYear "2018" @default.
• W2894868652 type Work @default.
• W2894868652 sameAs 2894868652 @default.
• W2894868652 citedByCount "37" @default.
• W2894868652 countsByYear W28948686522019 @default.
• W2894868652 countsByYear W28948686522020 @default.
• W2894868652 countsByYear W28948686522021 @default.
• W2894868652 countsByYear W28948686522022 @default.
• W2894868652 countsByYear W28948686522023 @default.
• W2894868652 crossrefType "journal-article" @default.
• W2894868652 hasAuthorship W2894868652A5007703380 @default.
• W2894868652 hasAuthorship W2894868652A5017014383 @default.
• W2894868652 hasAuthorship W2894868652A5024577714 @default.
• W2894868652 hasAuthorship W2894868652A5027835055 @default.
• W2894868652 hasAuthorship W2894868652A5039712648 @default.
• W2894868652 hasAuthorship W2894868652A5074770112 @default.
• W2894868652 hasAuthorship W2894868652A5076512552 @default.
• W2894868652 hasAuthorship W2894868652A5087479827 @default.
• W2894868652 hasAuthorship W2894868652A5090541536 @default.
• W2894868652 hasConcept C124160383 @default.
• W2894868652 hasConcept C126322002 @default.
• W2894868652 hasConcept C134018914 @default.
• W2894868652 hasConcept C142724271 @default.
• W2894868652 hasConcept C184235292 @default.
• W2894868652 hasConcept C185592680 @default.
• W2894868652 hasConcept C204787440 @default.
• W2894868652 hasConcept C2776151105 @default.
• W2894868652 hasConcept C2778833331 @default.
• W2894868652 hasConcept C2780091579 @default.
• W2894868652 hasConcept C2780124434 @default.
• W2894868652 hasConcept C51551487 @default.
• W2894868652 hasConcept C55493867 @default.
• W2894868652 hasConcept C71924100 @default.
• W2894868652 hasConcept C90934575 @default.
• W2894868652 hasConcept C97029542 @default.
• W2894868652 hasConcept C98274493 @default.
• W2894868652 hasConceptScore W2894868652C124160383 @default.
• W2894868652 hasConceptScore W2894868652C126322002 @default.
• W2894868652 hasConceptScore W2894868652C134018914 @default.
• W2894868652 hasConceptScore W2894868652C142724271 @default.
• W2894868652 hasConceptScore W2894868652C184235292 @default.
• W2894868652 hasConceptScore W2894868652C185592680 @default.
• W2894868652 hasConceptScore W2894868652C204787440 @default.
• W2894868652 hasConceptScore W2894868652C2776151105 @default.
• W2894868652 hasConceptScore W2894868652C2778833331 @default.
• W2894868652 hasConceptScore W2894868652C2780091579 @default.
• W2894868652 hasConceptScore W2894868652C2780124434 @default.
• W2894868652 hasConceptScore W2894868652C51551487 @default.
• W2894868652 hasConceptScore W2894868652C55493867 @default.
• W2894868652 hasConceptScore W2894868652C71924100 @default.
• W2894868652 hasConceptScore W2894868652C90934575 @default.
• W2894868652 hasConceptScore W2894868652C97029542 @default.
• W2894868652 hasConceptScore W2894868652C98274493 @default.

• next