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- W2894871867 abstract "Regenerative capacity is widespread throughout almost all animal phyla. However, the distribution pattern remains incompletely understood. Various examples show that very closely related species display different regenerative capacities. Why and how have diverse regenerative capacities evolved across species? One prevailing thought in the field of regeneration is that most regeneration-associated factors are evolutionarily conserved, suggesting the existence of an innate tissue regeneration ability in all species. However, its regulation is differentially controlled in distinct species, resulting in heterogeneous regenerative capabilities. In this review, we discuss regeneration-associated enhancers, the key cis-regulatory elements controlling gene expression, their underlying molecular mechanisms, and their influence on regenerative capacity. Understanding the regulatory mechanisms of regeneration enhancers can provide fundamental insights into tissue regeneration and further help us develop therapeutic strategies to unlock latent healing powers in humans. Developmental Dynamics 248:34–42, 2019. © 2018 Wiley Periodicals, Inc." @default.
- W2894871867 created "2018-10-12" @default.
- W2894871867 creator A5021446457 @default.
- W2894871867 creator A5087552175 @default.
- W2894871867 date "2018-11-28" @default.
- W2894871867 modified "2023-10-17" @default.
- W2894871867 title "Tissue Regeneration Enhancer Elements: A Way to Unlock Endogenous Healing Power" @default.
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- W2894871867 doi "https://doi.org/10.1002/dvdy.24676" @default.
- W2894871867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30291668" @default.
- W2894871867 hasPublicationYear "2018" @default.
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