Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894872021> ?p ?o ?g. }
- W2894872021 abstract "Abstract Objective: Many scientists and laypeople alike have concerns about low‐calorie sweeteners (LCSs). These concerns stem from both a dissatisfaction with the taste of LCSs and reports that they cause metabolic disruptions (e.g., weight gain, glucose intolerance). Methods: This article provides a critical review of the literature on LCSs from the standpoint of their taste, gastrointestinal, and metabolic effects; biological fate in the body; and impact on ingestion and glucose homeostasis. Results and Conclusions: Mammals can readily discriminate between LCSs and sugars because both types of sweetener activate distinct oral and post‐oral sensory pathways. LCSs differ in their ability to access post‐oral tissues, but few studies have incorporated this observation into their design. It is difficult to extrapolate results between mice, rats, and humans because of interspecies differences in the taste and post‐oral actions of LCSs and the fact that investigators often use different response measures in rodents and humans. There is confounding in the experimental design of some of the most widely cited studies of LCS‐induced metabolic disruptions. The uncritical acceptance of these studies has generated considerable controversy. More work is needed to obtain a clearer understanding of the metabolic effects of LCSs." @default.
- W2894872021 created "2018-10-12" @default.
- W2894872021 creator A5057959796 @default.
- W2894872021 date "2018-10-01" @default.
- W2894872021 modified "2023-10-06" @default.
- W2894872021 title "Oral and Post‐Oral Actions of Low‐Calorie Sweeteners: A Tale of Contradictions and Controversies" @default.
- W2894872021 cites W1509264826 @default.
- W2894872021 cites W1616790409 @default.
- W2894872021 cites W1902126526 @default.
- W2894872021 cites W1964304136 @default.
- W2894872021 cites W1964468911 @default.
- W2894872021 cites W1965466965 @default.
- W2894872021 cites W1969027628 @default.
- W2894872021 cites W1972849426 @default.
- W2894872021 cites W1977343242 @default.
- W2894872021 cites W1977878035 @default.
- W2894872021 cites W1978845732 @default.
- W2894872021 cites W1982365101 @default.
- W2894872021 cites W1983108533 @default.
- W2894872021 cites W1984085793 @default.
- W2894872021 cites W1984510346 @default.
- W2894872021 cites W1986387206 @default.
- W2894872021 cites W1987198829 @default.
- W2894872021 cites W1989947363 @default.
- W2894872021 cites W1991010763 @default.
- W2894872021 cites W1994656717 @default.
- W2894872021 cites W1998115254 @default.
- W2894872021 cites W2000547157 @default.
- W2894872021 cites W2004188327 @default.
- W2894872021 cites W2006659948 @default.
- W2894872021 cites W2010348504 @default.
- W2894872021 cites W2010545757 @default.
- W2894872021 cites W2013092705 @default.
- W2894872021 cites W2016443228 @default.
- W2894872021 cites W2017533053 @default.
- W2894872021 cites W2018768372 @default.
- W2894872021 cites W2019112449 @default.
- W2894872021 cites W2023516685 @default.
- W2894872021 cites W2025221894 @default.
- W2894872021 cites W2030645331 @default.
- W2894872021 cites W2040945084 @default.
- W2894872021 cites W2041624484 @default.
- W2894872021 cites W2042475399 @default.
- W2894872021 cites W2045343006 @default.
- W2894872021 cites W2045442869 @default.
- W2894872021 cites W2045988335 @default.
- W2894872021 cites W2048803504 @default.
- W2894872021 cites W2050736824 @default.
- W2894872021 cites W2053142881 @default.
- W2894872021 cites W2064034213 @default.
- W2894872021 cites W2065277599 @default.
- W2894872021 cites W2067388704 @default.
- W2894872021 cites W2069218009 @default.
- W2894872021 cites W2071221439 @default.
- W2894872021 cites W2074732360 @default.
- W2894872021 cites W2076267406 @default.
- W2894872021 cites W2077799121 @default.
- W2894872021 cites W2081389615 @default.
- W2894872021 cites W2083215956 @default.
- W2894872021 cites W2084329579 @default.
- W2894872021 cites W2093088433 @default.
- W2894872021 cites W2095818109 @default.
- W2894872021 cites W2098414018 @default.
- W2894872021 cites W2099580424 @default.
- W2894872021 cites W2100505950 @default.
- W2894872021 cites W2111548886 @default.
- W2894872021 cites W2113464010 @default.
- W2894872021 cites W2116592293 @default.
- W2894872021 cites W2118304087 @default.
- W2894872021 cites W2120476264 @default.
- W2894872021 cites W2121807761 @default.
- W2894872021 cites W2121951329 @default.
- W2894872021 cites W2122060463 @default.
- W2894872021 cites W2124347793 @default.
- W2894872021 cites W2126440147 @default.
- W2894872021 cites W2126643384 @default.
- W2894872021 cites W2130284699 @default.
- W2894872021 cites W2140115878 @default.
- W2894872021 cites W2143353752 @default.
- W2894872021 cites W2143711162 @default.
- W2894872021 cites W2144036556 @default.
- W2894872021 cites W2144827439 @default.
- W2894872021 cites W2145839148 @default.
- W2894872021 cites W2147065286 @default.
- W2894872021 cites W2147288185 @default.
- W2894872021 cites W2149248541 @default.
- W2894872021 cites W2153719617 @default.
- W2894872021 cites W2153827707 @default.
- W2894872021 cites W2154043570 @default.
- W2894872021 cites W2155240946 @default.
- W2894872021 cites W2155286130 @default.
- W2894872021 cites W2161960007 @default.
- W2894872021 cites W2162823979 @default.
- W2894872021 cites W2164366280 @default.
- W2894872021 cites W2164578066 @default.
- W2894872021 cites W2165940444 @default.
- W2894872021 cites W2167365255 @default.
- W2894872021 cites W2167745320 @default.
- W2894872021 cites W2168568879 @default.
- W2894872021 cites W2170419237 @default.