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• W2894872393 abstract "Oxidative damage, mitochondrial dysfunction, and neuroinflammation are strongly implicated in the pathogenesis of neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD), and a substantial portion of elderly population at risk of these diseases requires nutritional intervention to benefit health due to lack of clinically relevant drugs. To this end, anti-inflammatory mechanisms of several phytochemicals such as curcumin, resveratrol, propolis, polyunsaturated fatty acids (PUFAs), and ginsenosides have been extensively studied. However, correlation of the phytochemicals with neuroinflammation or brain nutrition is not fully considered, especially in their therapeutic mechanism for neuronal damage or dysfunction. In this article, we review the advance in antioxidative and anti-inflammatory effects of phytochemicals and discuss the potential communication with brain microenvironment by improved gastrointestinal function, enhanced systemic immunity, and neuroprotective outcomes. These data show that phytochemicals may modulate and suppress neuroinflammation of the brain by several approaches: (1) reducing systemic inflammation and infiltration via the blood-brain barrier (BBB), (2) direct permeation into the brain parenchyma leading to neuroprotection, (3) enhancing integrity of disrupted BBB, and (4) vagal reflex-mediated nutrition and protection by gastrointestinal function signaling to the brain. Therefore, many phytochemicals have multiple potential neuroprotective approaches contributing to therapeutic benefit for pathogenesis of neurodegenerative diseases, and development of strategies for preventing these diseases represents a considerable public health concern and socioeconomic burden." @default.
• W2894872393 created "2018-10-12" @default.
• W2894872393 creator A5016321824 @default.
• W2894872393 creator A5038692128 @default.
• W2894872393 creator A5039364619 @default.
• W2894872393 creator A5087414308 @default.
• W2894872393 date "2018-10-08" @default.
• W2894872393 modified "2023-10-17" @default.
• W2894872393 title "Connection between Systemic Inflammation and Neuroinflammation Underlies Neuroprotective Mechanism of Several Phytochemicals in Neurodegenerative Diseases" @default.
• W2894872393 cites W1493890929 @default.
• W2894872393 cites W1601505462 @default.
• W2894872393 cites W1669514974 @default.
• W2894872393 cites W1827146465 @default.
• W2894872393 cites W1901457319 @default.
• W2894872393 cites W1967841083 @default.
• W2894872393 cites W1970606114 @default.
• W2894872393 cites W1971668970 @default.
• W2894872393 cites W1974049080 @default.
• W2894872393 cites W1974710557 @default.
• W2894872393 cites W1978530459 @default.
• W2894872393 cites W1981117947 @default.
• W2894872393 cites W1982779257 @default.
• W2894872393 cites W1986061017 @default.
• W2894872393 cites W1990882347 @default.
• W2894872393 cites W1992097194 @default.
• W2894872393 cites W1995525413 @default.
• W2894872393 cites W1997962428 @default.
• W2894872393 cites W2002797282 @default.
• W2894872393 cites W2002871634 @default.
• W2894872393 cites W2007582093 @default.
• W2894872393 cites W2014208353 @default.
• W2894872393 cites W2014860670 @default.
• W2894872393 cites W2015877607 @default.
• W2894872393 cites W2015879863 @default.
• W2894872393 cites W2017003937 @default.
• W2894872393 cites W2017569244 @default.
• W2894872393 cites W2017685479 @default.
• W2894872393 cites W2020060386 @default.
• W2894872393 cites W2032100985 @default.
• W2894872393 cites W2033260090 @default.
• W2894872393 cites W2037078206 @default.
• W2894872393 cites W2039103568 @default.
• W2894872393 cites W2039347141 @default.
• W2894872393 cites W2040630297 @default.
• W2894872393 cites W2041608466 @default.
• W2894872393 cites W2044742792 @default.
• W2894872393 cites W2049665969 @default.
• W2894872393 cites W2049691960 @default.
• W2894872393 cites W2052764387 @default.
• W2894872393 cites W2057752710 @default.
• W2894872393 cites W2062164771 @default.
• W2894872393 cites W2070292315 @default.
• W2894872393 cites W2073973554 @default.
• W2894872393 cites W2075211485 @default.
• W2894872393 cites W2075696999 @default.
• W2894872393 cites W2080333902 @default.
• W2894872393 cites W2090335624 @default.
• W2894872393 cites W2096299061 @default.
• W2894872393 cites W2098775852 @default.
• W2894872393 cites W2104551034 @default.
• W2894872393 cites W2106908363 @default.
• W2894872393 cites W2107710305 @default.
• W2894872393 cites W2107906835 @default.
• W2894872393 cites W2113818687 @default.
• W2894872393 cites W2114395277 @default.
• W2894872393 cites W2116802655 @default.
• W2894872393 cites W2119971031 @default.
• W2894872393 cites W2121515004 @default.
• W2894872393 cites W2130387644 @default.
• W2894872393 cites W2131837675 @default.
• W2894872393 cites W2135472617 @default.
• W2894872393 cites W2136417207 @default.
• W2894872393 cites W2138377603 @default.
• W2894872393 cites W2139203136 @default.
• W2894872393 cites W2149710778 @default.
• W2894872393 cites W2154313239 @default.
• W2894872393 cites W2156238979 @default.
• W2894872393 cites W2158978919 @default.
• W2894872393 cites W2168532323 @default.
• W2894872393 cites W2169592605 @default.
• W2894872393 cites W2170181503 @default.
• W2894872393 cites W2197775693 @default.
• W2894872393 cites W2216116692 @default.
• W2894872393 cites W2224347688 @default.
• W2894872393 cites W2339648830 @default.
• W2894872393 cites W2345400600 @default.
• W2894872393 cites W2345747767 @default.
• W2894872393 cites W2346113929 @default.
• W2894872393 cites W2424187774 @default.
• W2894872393 cites W2469512664 @default.
• W2894872393 cites W2558041282 @default.
• W2894872393 cites W2590085029 @default.
• W2894872393 cites W2594333208 @default.
• W2894872393 cites W2610699868 @default.
• W2894872393 cites W2614030581 @default.
• W2894872393 cites W2614299446 @default.
• W2894872393 cites W2615876762 @default.
• W2894872393 cites W2620626718 @default.

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