Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894873414> ?p ?o ?g. }
- W2894873414 abstract "Abstract Aging is a prominent risk factor for neurodegenerative disease. Defining gene expression mechanisms affecting healthy brain aging should lead to insight into genes that modulate susceptibility to disease. To define such mechanisms, we have pursued analysis of miR-34 mutants in Drosophila . The miR-34 mutant brain displays a gene expression profile of accelerated aging, and miR-34 upregulation is a potent suppressor of polyglutamine-induced neurodegeneration. We demonstrate that Pcl and Su(z)12 , two components of polycomb repressive complex 2, (PRC2), are targets of miR-34 , with implications for age-associated processes. Because PRC2 confers the repressive H3K27me3 mark, we hypothesize that miR-34 modulates PRC2 activity to relieve silencing of genes promoting healthful aging. Gene expression profiling of the brains of hypomorphic mutants in Enhancer of zeste ( E(z) ), the enzymatic methyltransferase component of PRC2, revealed a younger brain transcriptome profile and identified the small heat shock proteins as key genes reduced in expression with age." @default.
- W2894873414 created "2018-10-12" @default.
- W2894873414 creator A5030967805 @default.
- W2894873414 creator A5038969227 @default.
- W2894873414 creator A5050602232 @default.
- W2894873414 date "2018-10-10" @default.
- W2894873414 modified "2023-10-11" @default.
- W2894873414 title "MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging" @default.
- W2894873414 cites W1541950149 @default.
- W2894873414 cites W1619158228 @default.
- W2894873414 cites W1891332773 @default.
- W2894873414 cites W1969288350 @default.
- W2894873414 cites W1973333453 @default.
- W2894873414 cites W1978425510 @default.
- W2894873414 cites W1981149424 @default.
- W2894873414 cites W1985308585 @default.
- W2894873414 cites W1986015652 @default.
- W2894873414 cites W2002735780 @default.
- W2894873414 cites W2004360525 @default.
- W2894873414 cites W2008586929 @default.
- W2894873414 cites W2017117976 @default.
- W2894873414 cites W2023431124 @default.
- W2894873414 cites W2032817175 @default.
- W2894873414 cites W2039365544 @default.
- W2894873414 cites W2045949302 @default.
- W2894873414 cites W2046989794 @default.
- W2894873414 cites W2058386953 @default.
- W2894873414 cites W2060608189 @default.
- W2894873414 cites W2068468911 @default.
- W2894873414 cites W2074735887 @default.
- W2894873414 cites W2080876971 @default.
- W2894873414 cites W2089146881 @default.
- W2894873414 cites W2094253263 @default.
- W2894873414 cites W2095102047 @default.
- W2894873414 cites W2098555753 @default.
- W2894873414 cites W2099540110 @default.
- W2894873414 cites W2106762991 @default.
- W2894873414 cites W2111709760 @default.
- W2894873414 cites W2115299520 @default.
- W2894873414 cites W2119938322 @default.
- W2894873414 cites W2120021898 @default.
- W2894873414 cites W2120326869 @default.
- W2894873414 cites W2123419812 @default.
- W2894873414 cites W2127582027 @default.
- W2894873414 cites W2129692964 @default.
- W2894873414 cites W2134526812 @default.
- W2894873414 cites W2156576736 @default.
- W2894873414 cites W2157649587 @default.
- W2894873414 cites W2158217645 @default.
- W2894873414 cites W2162080206 @default.
- W2894873414 cites W2168745915 @default.
- W2894873414 cites W2169456326 @default.
- W2894873414 cites W2171296186 @default.
- W2894873414 cites W2179438025 @default.
- W2894873414 cites W2202444963 @default.
- W2894873414 cites W2264682687 @default.
- W2894873414 cites W2440693788 @default.
- W2894873414 cites W2512539438 @default.
- W2894873414 cites W2517275410 @default.
- W2894873414 cites W2558549679 @default.
- W2894873414 cites W2559458734 @default.
- W2894873414 cites W2568130786 @default.
- W2894873414 cites W2606197589 @default.
- W2894873414 cites W2767332403 @default.
- W2894873414 cites W2806379121 @default.
- W2894873414 doi "https://doi.org/10.1038/s41467-018-06592-5" @default.
- W2894873414 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6180074" @default.
- W2894873414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30305625" @default.
- W2894873414 hasPublicationYear "2018" @default.
- W2894873414 type Work @default.
- W2894873414 sameAs 2894873414 @default.
- W2894873414 citedByCount "32" @default.
- W2894873414 countsByYear W28948734142019 @default.
- W2894873414 countsByYear W28948734142020 @default.
- W2894873414 countsByYear W28948734142021 @default.
- W2894873414 countsByYear W28948734142022 @default.
- W2894873414 countsByYear W28948734142023 @default.
- W2894873414 crossrefType "journal-article" @default.
- W2894873414 hasAuthorship W2894873414A5030967805 @default.
- W2894873414 hasAuthorship W2894873414A5038969227 @default.
- W2894873414 hasAuthorship W2894873414A5050602232 @default.
- W2894873414 hasBestOaLocation W28948734141 @default.
- W2894873414 hasConcept C104317684 @default.
- W2894873414 hasConcept C119056186 @default.
- W2894873414 hasConcept C142724271 @default.
- W2894873414 hasConcept C143065580 @default.
- W2894873414 hasConcept C150194340 @default.
- W2894873414 hasConcept C150425827 @default.
- W2894873414 hasConcept C162317418 @default.
- W2894873414 hasConcept C165864922 @default.
- W2894873414 hasConcept C2776915012 @default.
- W2894873414 hasConcept C2776925932 @default.
- W2894873414 hasConcept C2779134260 @default.
- W2894873414 hasConcept C2780104201 @default.
- W2894873414 hasConcept C41091548 @default.
- W2894873414 hasConcept C50171091 @default.
- W2894873414 hasConcept C54355233 @default.
- W2894873414 hasConcept C71924100 @default.
- W2894873414 hasConcept C86803240 @default.
- W2894873414 hasConcept C95444343 @default.