FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894874582> ?p ?o ?g. }

• W2894874582 endingPage "337" @default.
• W2894874582 startingPage "333" @default.
• W2894874582 abstract "The present study investigated the extraction and purification technology of matrine from Sophora flavescens Ait. and the inhibitory effects of matrine on human nasopharyngeal carcinoma (NPC) CNE-2 cells. The matrine was extracted from Sophora flavescens Ait. by decocting using ethanol-aqueous solution as the solvent, followed by purification using ion exchange resin adsorption. The extraction and purification conditions were investigated. The effects of matrine on growth, cell apoptosis and cycle of CNE-2 cells and expressions of Bac-2 and caspase-3 protein in cells were detected. Results showed that, the optimal extraction and purification technologies of matrine from Sophora flavescens Ait. were obtained, under which the purity of matrine was 81.56%. Matrine could obtain inhibit the growth of CNE-2 cells, promote the cell apoptosis, and arrest most cells in G0/G1 phase. In addition, after treated matrine, the relative expression level of Bcl-2 protein in CNE-2 cells was decreased, and the expression level of Caspase-3 protein was increased. In conclusion, matrine has inhibitory effects on human NPC CNE-2 cells. The mechanism may be related to its down-regulation of Bcl-2 protein and up-regulation of Caspase-3 protein expression." @default.
• W2894874582 created "2018-10-12" @default.
• W2894874582 creator A5027024676 @default.
• W2894874582 creator A5061823647 @default.
• W2894874582 creator A5071389166 @default.
• W2894874582 date "2018-12-01" @default.
• W2894874582 modified "2023-10-17" @default.
• W2894874582 title "Extraction of matrine from Sophora flavescens Ait. and evaluation of its inhibitory effects on human nasopharyngeal carcinoma CNE-2 cells" @default.
• W2894874582 cites W2008757142 @default.
• W2894874582 cites W2019617863 @default.
• W2894874582 cites W2025211921 @default.
• W2894874582 cites W2025772346 @default.
• W2894874582 cites W2029328803 @default.
• W2894874582 cites W2029780933 @default.
• W2894874582 cites W2059234493 @default.
• W2894874582 cites W2059775855 @default.
• W2894874582 cites W2061212672 @default.
• W2894874582 cites W2065177893 @default.
• W2894874582 cites W2093580833 @default.
• W2894874582 cites W2151645021 @default.
• W2894874582 cites W2171001387 @default.
• W2894874582 cites W2237260456 @default.
• W2894874582 doi "https://doi.org/10.1590/fst.24117" @default.
• W2894874582 hasPublicationYear "2018" @default.
• W2894874582 type Work @default.
• W2894874582 sameAs 2894874582 @default.
• W2894874582 citedByCount "2" @default.
• W2894874582 countsByYear W28948745822021 @default.
• W2894874582 crossrefType "journal-article" @default.
• W2894874582 hasAuthorship W2894874582A5027024676 @default.
• W2894874582 hasAuthorship W2894874582A5061823647 @default.
• W2894874582 hasAuthorship W2894874582A5071389166 @default.
• W2894874582 hasBestOaLocation W28948745821 @default.
• W2894874582 hasConcept C126322002 @default.
• W2894874582 hasConcept C142724271 @default.
• W2894874582 hasConcept C153911025 @default.
• W2894874582 hasConcept C169760540 @default.
• W2894874582 hasConcept C17077164 @default.
• W2894874582 hasConcept C185592680 @default.
• W2894874582 hasConcept C188947578 @default.
• W2894874582 hasConcept C190283241 @default.
• W2894874582 hasConcept C202751555 @default.
• W2894874582 hasConcept C204787440 @default.
• W2894874582 hasConcept C2776545273 @default.
• W2894874582 hasConcept C2776625710 @default.
• W2894874582 hasConcept C2777752497 @default.
• W2894874582 hasConcept C2778484605 @default.
• W2894874582 hasConcept C2778997737 @default.
• W2894874582 hasConcept C43617362 @default.
• W2894874582 hasConcept C4725764 @default.
• W2894874582 hasConcept C509974204 @default.
• W2894874582 hasConcept C54355233 @default.
• W2894874582 hasConcept C55493867 @default.
• W2894874582 hasConcept C71924100 @default.
• W2894874582 hasConcept C81885089 @default.
• W2894874582 hasConcept C86803240 @default.
• W2894874582 hasConcept C98274493 @default.
• W2894874582 hasConceptScore W2894874582C126322002 @default.
• W2894874582 hasConceptScore W2894874582C142724271 @default.
• W2894874582 hasConceptScore W2894874582C153911025 @default.
• W2894874582 hasConceptScore W2894874582C169760540 @default.
• W2894874582 hasConceptScore W2894874582C17077164 @default.
• W2894874582 hasConceptScore W2894874582C185592680 @default.
• W2894874582 hasConceptScore W2894874582C188947578 @default.
• W2894874582 hasConceptScore W2894874582C190283241 @default.
• W2894874582 hasConceptScore W2894874582C202751555 @default.
• W2894874582 hasConceptScore W2894874582C204787440 @default.
• W2894874582 hasConceptScore W2894874582C2776545273 @default.
• W2894874582 hasConceptScore W2894874582C2776625710 @default.
• W2894874582 hasConceptScore W2894874582C2777752497 @default.
• W2894874582 hasConceptScore W2894874582C2778484605 @default.
• W2894874582 hasConceptScore W2894874582C2778997737 @default.
• W2894874582 hasConceptScore W2894874582C43617362 @default.
• W2894874582 hasConceptScore W2894874582C4725764 @default.
• W2894874582 hasConceptScore W2894874582C509974204 @default.
• W2894874582 hasConceptScore W2894874582C54355233 @default.
• W2894874582 hasConceptScore W2894874582C55493867 @default.
• W2894874582 hasConceptScore W2894874582C71924100 @default.
• W2894874582 hasConceptScore W2894874582C81885089 @default.
• W2894874582 hasConceptScore W2894874582C86803240 @default.
• W2894874582 hasConceptScore W2894874582C98274493 @default.
• W2894874582 hasIssue "suppl 1" @default.
• W2894874582 hasLocation W28948745821 @default.
• W2894874582 hasLocation W28948745822 @default.
• W2894874582 hasLocation W28948745823 @default.
• W2894874582 hasOpenAccess W2894874582 @default.
• W2894874582 hasPrimaryLocation W28948745821 @default.
• W2894874582 hasRelatedWork W2088380495 @default.
• W2894874582 hasRelatedWork W2356778945 @default.
• W2894874582 hasRelatedWork W2371943096 @default.
• W2894874582 hasRelatedWork W2374451538 @default.
• W2894874582 hasRelatedWork W2379263982 @default.
• W2894874582 hasRelatedWork W2383810872 @default.
• W2894874582 hasRelatedWork W2894874582 @default.
• W2894874582 hasRelatedWork W2989423412 @default.
• W2894874582 hasRelatedWork W3016288746 @default.
• W2894874582 hasRelatedWork W37001106 @default.
• W2894874582 hasVolume "38" @default.

• next