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- W2894875946 abstract "A series of Wrightia hanleyi extracts was screened for activity against Mycobacterium tuberculosis H37Rv. One active fraction contained a compound that initially appeared to be either the isoflavonoid wrightiadione or the alkaloid tryptanthrin, both of which have been previously reported in other Wrightia species. Characterization by NMR and MS, as well as evaluation of the literature describing these compounds, led to the conclusion that wrightiadione (1) was misidentified in the first report of its isolation from W. tomentosa in 1992 and again in 2015 when reported in W. pubescens and W. religiosa. Instead, the molecule described in these reports and in the present work is almost certainly the isobaric (same nominal mass) and isosteric (same number of atoms, valency, and shape) tryptanthrin (2), a well-known quinazolinone alkaloid found in a variety of plants including Wrightia species. Tryptanthrin (2) is also accessible synthetically via several routes and has been thoroughly characterized. Wrightiadione (1) has been synthesized and characterized and may have useful biological activity; however, this compound can no longer be said to be known to exist in Nature. To our knowledge, this misidentification of wrightiadione (1) has heretofore been unrecognized." @default.
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- W2894875946 date "2018-10-08" @default.
- W2894875946 modified "2023-09-26" @default.
- W2894875946 title "Isolation of Tryptanthrin and Reassessment of Evidence for Its Isobaric Isostere Wrightiadione in Plants of the <i>Wrightia</i> Genus" @default.
- W2894875946 cites W166848320 @default.
- W2894875946 cites W1749898158 @default.
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- W2894875946 cites W1970336072 @default.
- W2894875946 cites W1975647914 @default.
- W2894875946 cites W1976425786 @default.
- W2894875946 cites W1986908175 @default.
- W2894875946 cites W1998054508 @default.
- W2894875946 cites W2006123730 @default.
- W2894875946 cites W2011146251 @default.
- W2894875946 cites W2012547208 @default.
- W2894875946 cites W2022018899 @default.
- W2894875946 cites W2022673999 @default.
- W2894875946 cites W2023146085 @default.
- W2894875946 cites W2028046413 @default.
- W2894875946 cites W2031302730 @default.
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- W2894875946 cites W2046424037 @default.
- W2894875946 cites W2049996223 @default.
- W2894875946 cites W2050036030 @default.
- W2894875946 cites W2050314581 @default.
- W2894875946 cites W2051529512 @default.
- W2894875946 cites W2058151515 @default.
- W2894875946 cites W2065167162 @default.
- W2894875946 cites W2067700384 @default.
- W2894875946 cites W2072036032 @default.
- W2894875946 cites W2083963989 @default.
- W2894875946 cites W2085820343 @default.
- W2894875946 cites W2087409438 @default.
- W2894875946 cites W2088482039 @default.
- W2894875946 cites W2091474459 @default.
- W2894875946 cites W2104897032 @default.
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- W2894875946 cites W2136906178 @default.
- W2894875946 cites W2147421370 @default.
- W2894875946 cites W2150534844 @default.
- W2894875946 cites W2151220474 @default.
- W2894875946 cites W2154197062 @default.
- W2894875946 cites W2156118208 @default.
- W2894875946 cites W2162988052 @default.
- W2894875946 cites W2165090720 @default.
- W2894875946 cites W2173569804 @default.
- W2894875946 cites W2179429383 @default.
- W2894875946 cites W2190426270 @default.
- W2894875946 cites W2312591112 @default.
- W2894875946 cites W2320165253 @default.
- W2894875946 cites W2429432645 @default.
- W2894875946 cites W2507869595 @default.
- W2894875946 cites W2531280094 @default.
- W2894875946 cites W2534732499 @default.
- W2894875946 cites W2560273460 @default.
- W2894875946 cites W2594306208 @default.
- W2894875946 cites W2601497469 @default.
- W2894875946 cites W2732320566 @default.
- W2894875946 cites W2737211256 @default.
- W2894875946 cites W2885074006 @default.
- W2894875946 cites W2950718560 @default.
- W2894875946 cites W2951799875 @default.
- W2894875946 cites W2951975754 @default.
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- W2894875946 cites W4230413343 @default.
- W2894875946 cites W4377077031 @default.
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- W2894875946 doi "https://doi.org/10.1021/acs.jnatprod.8b00567" @default.
- W2894875946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30295480" @default.
- W2894875946 hasPublicationYear "2018" @default.
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