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- W2894878935 abstract "Background: During pregnancy the risk of rupture of hepatocellular adenomas (HCA) is associated with a potential foetal and maternal mortality. The aim of the study was to look for HCA complications during pregnancies. Material and methods: We retrieved four cases of ruptured HCA among our series of resected phenotypically characterized HCA. Results: The 4 cases were primipara at 30, 31, 36, 40 weeks of amenorrhea. The 3 first cases had a cesarean following the hemorrhage. In the last case cesarean occurred 6 days after a planned indication. Two out of four children survive. The outcome of the women was good. The subtyping revealed 2 b-HCA ex7, 1 b-HCA ex3 S45 and 1 ASS1+HCA. For comparison, the respective % of acute hemorrhagic bleeding in our population of 218 resected HCA was < 10 % in H-HCA, IHCA, b-IHCA but 27.2% in b-HCA (all ex3 S45 , ex7) and 31.8% in ASS1+HCA. No complication occurred among our resected HCA cases (190 women): 131 pregnancies after (17 cases) or prior (120 cases) surgery; 21 pregnancies occurred five years preceding surgery, among them, 4 - phenotypically different from the 4 ruptured cases- occurring in less than 1 year. Discussion: ASS1+HCA and b-HCA (ex3 S45 and 7/8) HCA at a higher risk of bleeding may perhaps favor HCA dramatic hemorrhage during pregnancy. Conclusion: The results of this small series need to be confirmed through an international registration for pregnant patients with proven HCA to identify if these subtypes are true risk factors in this context." @default.
- W2894878935 created "2018-10-12" @default.
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- W2894878935 date "2018-09-01" @default.
- W2894878935 modified "2023-10-17" @default.
- W2894878935 title "Ruptured hepatocellular adenoma during pregnancy. Will subtype identification become clinically relevant?" @default.
- W2894878935 doi "https://doi.org/10.1016/j.hpb.2018.06.2695" @default.
- W2894878935 hasPublicationYear "2018" @default.
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