Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894879561> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W2894879561 abstract "This short and concise paper was the first to unequivocally reveal that there were endogenous opioids in the central nervous system (CNS), identify their peptide nature and sequence, and show that they exerted physiological inhibitory effects. The idea that there were natural opioids fitted with concurrent reports of opiate-binding sites, and this led to the description of multiple receptors with their own families of peptide transmitters. No truly novel opioid drugs have emerged since, and attempts to protect and manipulate the enkephalins for pain control have yet to be successful. This does not detract from this key study, which made us think about pain modulation in a different way, and subsequent work has clearly shown how endogenous opioid signalling is critical in CNS function, perhaps most importantly in endogenous pain control, such as that harnessed by placebo analgesia." @default.
- W2894879561 created "2018-10-12" @default.
- W2894879561 creator A5042937645 @default.
- W2894879561 date "2018-09-01" @default.
- W2894879561 modified "2023-09-24" @default.
- W2894879561 title "Endogenous opioids in the CNS" @default.
- W2894879561 doi "https://doi.org/10.1093/med/9780198834359.003.0019" @default.
- W2894879561 hasPublicationYear "2018" @default.
- W2894879561 type Work @default.
- W2894879561 sameAs 2894879561 @default.
- W2894879561 citedByCount "0" @default.
- W2894879561 crossrefType "book" @default.
- W2894879561 hasAuthorship W2894879561A5042937645 @default.
- W2894879561 hasConcept C126322002 @default.
- W2894879561 hasConcept C15744967 @default.
- W2894879561 hasConcept C16613235 @default.
- W2894879561 hasConcept C169760540 @default.
- W2894879561 hasConcept C170493617 @default.
- W2894879561 hasConcept C17077164 @default.
- W2894879561 hasConcept C2778140631 @default.
- W2894879561 hasConcept C2781063702 @default.
- W2894879561 hasConcept C3017995582 @default.
- W2894879561 hasConcept C529278444 @default.
- W2894879561 hasConcept C71924100 @default.
- W2894879561 hasConcept C88016717 @default.
- W2894879561 hasConcept C98274493 @default.
- W2894879561 hasConceptScore W2894879561C126322002 @default.
- W2894879561 hasConceptScore W2894879561C15744967 @default.
- W2894879561 hasConceptScore W2894879561C16613235 @default.
- W2894879561 hasConceptScore W2894879561C169760540 @default.
- W2894879561 hasConceptScore W2894879561C170493617 @default.
- W2894879561 hasConceptScore W2894879561C17077164 @default.
- W2894879561 hasConceptScore W2894879561C2778140631 @default.
- W2894879561 hasConceptScore W2894879561C2781063702 @default.
- W2894879561 hasConceptScore W2894879561C3017995582 @default.
- W2894879561 hasConceptScore W2894879561C529278444 @default.
- W2894879561 hasConceptScore W2894879561C71924100 @default.
- W2894879561 hasConceptScore W2894879561C88016717 @default.
- W2894879561 hasConceptScore W2894879561C98274493 @default.
- W2894879561 hasLocation W28948795611 @default.
- W2894879561 hasOpenAccess W2894879561 @default.
- W2894879561 hasPrimaryLocation W28948795611 @default.
- W2894879561 hasRelatedWork W1977493234 @default.
- W2894879561 hasRelatedWork W1981839548 @default.
- W2894879561 hasRelatedWork W2021649598 @default.
- W2894879561 hasRelatedWork W2076409756 @default.
- W2894879561 hasRelatedWork W2150466252 @default.
- W2894879561 hasRelatedWork W2208259050 @default.
- W2894879561 hasRelatedWork W2407294081 @default.
- W2894879561 hasRelatedWork W2408420512 @default.
- W2894879561 hasRelatedWork W2409687529 @default.
- W2894879561 hasRelatedWork W2418383066 @default.
- W2894879561 isParatext "false" @default.
- W2894879561 isRetracted "false" @default.
- W2894879561 magId "2894879561" @default.
- W2894879561 workType "book" @default.