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- W2894881340 abstract "Introduction: The prognosis of pancreatic carcinoma (PC) remains poor and the AJCC 8th staging system for survival prediction in PC patients after curative resection is still limited. Methods: The data of 3,458 patients used in this study were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. The prognostic value of lymph node ratio (LNR) was analyzed in the primary cohort and prognostic nomogram based on LNR was established to create a novel staging system. Then, analyses were conducted to evaluate the application of the formulated nomogram staging system and AJCC 8th staging system. Results: Significant positive correlations were found between LNR and all factors except for surgical procedures. The results of univariate and multivariate analysis showed, LNR was identified as an independent prognostic indicator for OS in both primary and validation cohorts (all P< 0.001). A prognostic nomogram based on LNR was formulated to obtain superior discriminatory abilities. Compared with the AJCC 8th staging system, the formulated nomogram staying system showed higher HRs of stage II, III and IV disease (reference to stage I disease) by univariate analyses in the primary cohort and the distinction between stage I, II and III disease of the survival curves was more apparent. Conclusion: LNR can be considered as a useful independent prognostic indicator for PC patients following curative resection regardless of the surgical procedures. Compared with the AJCC 8th staging system, the formulated nomogram showed superior predictive accuracy for OS and its novel staging system revealed better risk stratification." @default.
- W2894881340 created "2018-10-12" @default.
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- W2894881340 date "2018-09-01" @default.
- W2894881340 modified "2023-10-16" @default.
- W2894881340 title "Comparison of prognostic prediction between nomogram based on lymph node ratio and AJCC 8th staging system for patients with resected pancreatic carcinoma: a SEER analysis" @default.
- W2894881340 doi "https://doi.org/10.1016/j.hpb.2018.06.1942" @default.
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