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- W2894883964 abstract "Introduction: Preoperative inflammatory and nutritional status scores and biomarkers (neutrophil/lymphocyte ratio NLR, platelet/lymphocyte ratio PLR, prognostic nutritional index PNI, Glasgow prognostic score GPS, albumin and prealbumin) analysis for prediction of morbidity after pancreatoduodenectomy (PD). Methods: Prospective case-control analysis of consecutive PD performed during 2015, 2016 and 2017 at Rio-Hortega University Hospital (Valladolid, Spain). Main outcomes: overall morbidity (OM), Clavien ≥III morbidity, surgical site infection (SSI). Secondary outcomes: gastroparesis, pancreatic fistula (PF), hemorrhage (according to ISGPS: no appearance versus grades A, B and C). Mean values of NLR, PLR, PNI, GPS, albumin and prealbumin (obtained from blood samples immediately before operation) were compared among cases (complication appearance) and control patients. ROC curves and AUC were obtained. Statistics: SPSS 24. Results: 41 patients (age 64.1 ± 10.5 years, 61% males). Rates of OM, Clavien ≥III morbidity, SSI, gastroparesis, PF, hemorrhage were respectively: 87.8%, 34.1%, 19.5%, 37.5%, 26.8%, 24.4%. Statistical association was found between:-NLR: higher values among cases suffering SSI (1.56 versus 2.29, p = 0.015).-PLR: higher values among cases suffering PF (102 versus 135, p = 0.025) and SSI (102 versus 148, p = 0.03).-Prealbumin: lower value among cases suffering Clavien ≥III morbidity (18.3 versus 24.4, p = 0.04). Highest AUC was obtained for PLR and SSI (0.837, 95% CI = 0.690–0.985, p = 0.006) Conclusion: Impaired inflammatory and nutritional condition is somehow associated with worse outcomes after PD. Particularly, PLR and prealbumin might predict PF and severe morbidity, respectively." @default.
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- W2894883964 date "2018-09-01" @default.
- W2894883964 modified "2023-10-14" @default.
- W2894883964 title "Preoperative inflammatory and nutritional status scores and biomarkers associated with morbidity after whipple procedure" @default.
- W2894883964 doi "https://doi.org/10.1016/j.hpb.2018.06.2143" @default.
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