Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894884627> ?p ?o ?g. }
- W2894884627 endingPage "862" @default.
- W2894884627 startingPage "853" @default.
- W2894884627 abstract "Abstract Autoantibodies (Ab) against the thyroid-stimulating hormone receptor (TSHR) are frequently found in autoimmune thyroid disease (AITD). Autoantibodies to the TSHR (anti-TSHR-Ab) may mimic or block the action of TSH or be functionally neutral. Measurement of anti-TSHR-Ab can be done either via competitive-binding immunoassays or with functional cell-based bioassays. Antibody-binding assays do not assess anti-TSHR-Ab functionality, but rather measure the concentration of total anti-TSHR binding activity. In contrast, functional cell-based bioassays indicate whether anti-TSHR-Ab have stimulatory or blocking activity. Historically bioassays for anti-TSHR-Ab were research tools and were used to study the pathophysiology of Graves’ disease and Hashimoto’s thyroiditis. In the past, bioassays for anti-TSHR-Abs were laborious and time-consuming and varied widely in performance from laboratory to laboratory. Recent advances in the development of cell-based assays, including the application of molecular engineering, have led to significant improvements that have enabled bioassays to be employed routinely in clinical laboratories. The prevalence and functional significance of TSHR blocking autoantibodies (TBAb) in autoimmune hypothyroidism has been less well investigated compared to TSHR stimulating Ab. There is an increasing body of data, however, that demonstrate the clinical utility and relevance of TBAb, and thus the importance of TBAb bioassays, in the diagnosis and management of patients with AITD. In the present review, we summarize the different methods used to measure TBAb, and discuss their prevalence and clinical relevance." @default.
- W2894884627 created "2018-10-12" @default.
- W2894884627 creator A5026096108 @default.
- W2894884627 creator A5061859868 @default.
- W2894884627 creator A5087797414 @default.
- W2894884627 date "2018-10-04" @default.
- W2894884627 modified "2023-09-25" @default.
- W2894884627 title "Thyrotropin Receptor Blocking Antibodies" @default.
- W2894884627 cites W1424218273 @default.
- W2894884627 cites W1514099677 @default.
- W2894884627 cites W1532552429 @default.
- W2894884627 cites W1545429987 @default.
- W2894884627 cites W1562512263 @default.
- W2894884627 cites W1833485294 @default.
- W2894884627 cites W1833803062 @default.
- W2894884627 cites W1858708606 @default.
- W2894884627 cites W1963882628 @default.
- W2894884627 cites W1965540553 @default.
- W2894884627 cites W1965602277 @default.
- W2894884627 cites W1966182992 @default.
- W2894884627 cites W1967826302 @default.
- W2894884627 cites W1970510439 @default.
- W2894884627 cites W1970889448 @default.
- W2894884627 cites W1977053282 @default.
- W2894884627 cites W1986466209 @default.
- W2894884627 cites W1986886858 @default.
- W2894884627 cites W1987237609 @default.
- W2894884627 cites W1988024316 @default.
- W2894884627 cites W1989090634 @default.
- W2894884627 cites W1990884150 @default.
- W2894884627 cites W1996017316 @default.
- W2894884627 cites W1999268386 @default.
- W2894884627 cites W1999559912 @default.
- W2894884627 cites W2001018298 @default.
- W2894884627 cites W2001676232 @default.
- W2894884627 cites W2007215155 @default.
- W2894884627 cites W2009767355 @default.
- W2894884627 cites W2015988460 @default.
- W2894884627 cites W2021393580 @default.
- W2894884627 cites W2022763964 @default.
- W2894884627 cites W2029110143 @default.
- W2894884627 cites W2029163502 @default.
- W2894884627 cites W2030897875 @default.
- W2894884627 cites W2036548751 @default.
- W2894884627 cites W2039228561 @default.
- W2894884627 cites W2051773936 @default.
- W2894884627 cites W2054541327 @default.
- W2894884627 cites W2055157436 @default.
- W2894884627 cites W2057049757 @default.
- W2894884627 cites W2058652720 @default.
- W2894884627 cites W2063530353 @default.
- W2894884627 cites W2065639350 @default.
- W2894884627 cites W2068521846 @default.
- W2894884627 cites W2069760799 @default.
- W2894884627 cites W2070210853 @default.
- W2894884627 cites W2079441126 @default.
- W2894884627 cites W2081178070 @default.
- W2894884627 cites W2083189217 @default.
- W2894884627 cites W2090537552 @default.
- W2894884627 cites W2092132260 @default.
- W2894884627 cites W2095336326 @default.
- W2894884627 cites W2109271955 @default.
- W2894884627 cites W2115395748 @default.
- W2894884627 cites W2117150544 @default.
- W2894884627 cites W2128266208 @default.
- W2894884627 cites W2132386964 @default.
- W2894884627 cites W2137096201 @default.
- W2894884627 cites W2137130104 @default.
- W2894884627 cites W2143573937 @default.
- W2894884627 cites W2149518418 @default.
- W2894884627 cites W2151640744 @default.
- W2894884627 cites W2151667933 @default.
- W2894884627 cites W2153833759 @default.
- W2894884627 cites W2158598357 @default.
- W2894884627 cites W2168517373 @default.
- W2894884627 cites W2168719505 @default.
- W2894884627 cites W2169132215 @default.
- W2894884627 cites W2170143753 @default.
- W2894884627 cites W2290817103 @default.
- W2894884627 cites W2292578945 @default.
- W2894884627 cites W2315657022 @default.
- W2894884627 cites W2342019290 @default.
- W2894884627 cites W2398091061 @default.
- W2894884627 cites W2404666969 @default.
- W2894884627 cites W2407770516 @default.
- W2894884627 cites W2417893382 @default.
- W2894884627 cites W2547673960 @default.
- W2894884627 cites W2588222829 @default.
- W2894884627 cites W2609737451 @default.
- W2894884627 cites W2742639617 @default.
- W2894884627 cites W2805015628 @default.
- W2894884627 cites W4248098588 @default.
- W2894884627 cites W4252323030 @default.
- W2894884627 cites W2075731118 @default.
- W2894884627 doi "https://doi.org/10.1055/a-0723-9023" @default.
- W2894884627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6290727" @default.
- W2894884627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30286485" @default.
- W2894884627 hasPublicationYear "2018" @default.