FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894890008> ?p ?o ?g. }

• W2894890008 endingPage "88" @default.
• W2894890008 startingPage "79" @default.
• W2894890008 abstract "Escin (β-escin) is used as traditional folk medicine. The anti-tumour effects of escin have been demonstrated in vitro in certain cell lines, but its effect on bladder cancer has not been well investigated. In this study, the apoptotic activity of escin dissolved in dimethyl sulfoxide (DMSO) in bladder cancer cells and normal peripheral blood mononuclear cells (PBMC) and SV-HUC1 cells (controls) was determined. Cell cytotoxicity was assessed using the MTT assay. Cell cycle, Reactive oxygen species (ROS) generation, annexin V-FITC staining (for detecting early apoptosis), and changes in mitochondrial membrane potential were evaluated using flow cytometry. Expression of apoptosis-related proteins such as Fas (CD95) death receptor/FADD (Fas-associated protein with death domain) and BCL2 family of proteins was assessed using immunoblotting. Escin dose-dependently inhibited the growth of human bladder cancer cells, and showed IC50 of ~40 μM. The cell population in the sub-G1 phase, annexin-V staining, Fas expression, ratio of BAX/BCL2, cleavage of activated caspase-3/-8/-9, increase in poly (ADP-ribose) polymerase (PARP) levels, and suppression of nuclear factor kappa B (NF-κB) were observed after 24 h of escin treatment. Escin decreased mitochondrial membrane potential and increased cytochrome C release via generation of reactive oxygen species, which led to apoptosis of bladder cancer cells. Furthermore, escin effectively inhibited bladder tumour growth in a xenograft mouse model. Together, these results demonstrate that escin induces apoptosis in human bladder cancer cells through the Fas death receptor and mitochondrial pathways and inhibits bladder tumour growth. Escin is a potential chemotherapeutic agent for bladder cancer." @default.
• W2894890008 created "2018-10-12" @default.
• W2894890008 creator A5004447689 @default.
• W2894890008 creator A5035483725 @default.
• W2894890008 creator A5042850501 @default.
• W2894890008 creator A5053549129 @default.
• W2894890008 creator A5065353699 @default.
• W2894890008 creator A5086754083 @default.
• W2894890008 creator A5091683814 @default.
• W2894890008 date "2018-12-01" @default.
• W2894890008 modified "2023-10-11" @default.
• W2894890008 title "Escin induces apoptosis in human bladder cancer cells: An in vitro and in vivo study" @default.
• W2894890008 cites W1552892674 @default.
• W2894890008 cites W1556732994 @default.
• W2894890008 cites W1577840857 @default.
• W2894890008 cites W1589415602 @default.
• W2894890008 cites W1881164779 @default.
• W2894890008 cites W1893097969 @default.
• W2894890008 cites W1969011764 @default.
• W2894890008 cites W1974912634 @default.
• W2894890008 cites W1978701708 @default.
• W2894890008 cites W1985239808 @default.
• W2894890008 cites W1991839037 @default.
• W2894890008 cites W1995124041 @default.
• W2894890008 cites W2009351346 @default.
• W2894890008 cites W2013384235 @default.
• W2894890008 cites W2025948298 @default.
• W2894890008 cites W2028336439 @default.
• W2894890008 cites W2034937201 @default.
• W2894890008 cites W2036822121 @default.
• W2894890008 cites W2050855275 @default.
• W2894890008 cites W2066040725 @default.
• W2894890008 cites W2081129794 @default.
• W2894890008 cites W2101060402 @default.
• W2894890008 cites W2112394810 @default.
• W2894890008 cites W2124343538 @default.
• W2894890008 cites W2126533485 @default.
• W2894890008 cites W2130166645 @default.
• W2894890008 cites W2155127143 @default.
• W2894890008 cites W2159164794 @default.
• W2894890008 cites W2162574319 @default.
• W2894890008 cites W2167223189 @default.
• W2894890008 cites W2170930147 @default.
• W2894890008 cites W2284905061 @default.
• W2894890008 cites W2290466312 @default.
• W2894890008 cites W2315685583 @default.
• W2894890008 cites W2514109067 @default.
• W2894890008 cites W2530631168 @default.
• W2894890008 cites W2564644795 @default.
• W2894890008 cites W2565371283 @default.
• W2894890008 cites W2609441489 @default.
• W2894890008 cites W2769288912 @default.
• W2894890008 doi "https://doi.org/10.1016/j.ejphar.2018.09.033" @default.
• W2894890008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30287153" @default.
• W2894890008 hasPublicationYear "2018" @default.
• W2894890008 type Work @default.
• W2894890008 sameAs 2894890008 @default.
• W2894890008 citedByCount "18" @default.
• W2894890008 countsByYear W28948900082020 @default.
• W2894890008 countsByYear W28948900082021 @default.
• W2894890008 countsByYear W28948900082022 @default.
• W2894890008 countsByYear W28948900082023 @default.
• W2894890008 crossrefType "journal-article" @default.
• W2894890008 hasAuthorship W2894890008A5004447689 @default.
• W2894890008 hasAuthorship W2894890008A5035483725 @default.
• W2894890008 hasAuthorship W2894890008A5042850501 @default.
• W2894890008 hasAuthorship W2894890008A5053549129 @default.
• W2894890008 hasAuthorship W2894890008A5065353699 @default.
• W2894890008 hasAuthorship W2894890008A5086754083 @default.
• W2894890008 hasAuthorship W2894890008A5091683814 @default.
• W2894890008 hasConcept C121608353 @default.
• W2894890008 hasConcept C153911025 @default.
• W2894890008 hasConcept C185592680 @default.
• W2894890008 hasConcept C190283241 @default.
• W2894890008 hasConcept C2776055636 @default.
• W2894890008 hasConcept C2780783641 @default.
• W2894890008 hasConcept C31573885 @default.
• W2894890008 hasConcept C48349386 @default.
• W2894890008 hasConcept C502942594 @default.
• W2894890008 hasConcept C54355233 @default.
• W2894890008 hasConcept C55493867 @default.
• W2894890008 hasConcept C86803240 @default.
• W2894890008 hasConcept C88634738 @default.
• W2894890008 hasConcept C95444343 @default.
• W2894890008 hasConcept C96232424 @default.
• W2894890008 hasConcept C98424977 @default.
• W2894890008 hasConceptScore W2894890008C121608353 @default.
• W2894890008 hasConceptScore W2894890008C153911025 @default.
• W2894890008 hasConceptScore W2894890008C185592680 @default.
• W2894890008 hasConceptScore W2894890008C190283241 @default.
• W2894890008 hasConceptScore W2894890008C2776055636 @default.
• W2894890008 hasConceptScore W2894890008C2780783641 @default.
• W2894890008 hasConceptScore W2894890008C31573885 @default.
• W2894890008 hasConceptScore W2894890008C48349386 @default.
• W2894890008 hasConceptScore W2894890008C502942594 @default.
• W2894890008 hasConceptScore W2894890008C54355233 @default.
• W2894890008 hasConceptScore W2894890008C55493867 @default.
• W2894890008 hasConceptScore W2894890008C86803240 @default.

• next