FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894890140> ?p ?o ?g. }

• W2894890140 endingPage "161" @default.
• W2894890140 startingPage "154" @default.
• W2894890140 abstract "Long non-coding RNAs (lncRNAs) have been identified to exert crucial roles in tumorigenesis and can serve as novel biomarkers for cancer therapy including lung cancer. Cisplatin is a first-line chemotherapeutic agent in non-small cell lung cancer (NSCLC), but the therapeutic effect is unsatisfactory, partly due to drug resistance. Emerging evidence showed that chemo-resistance is associated with acquisition of cancer stem cell (CSC)-like properties. Cisplatin resistance remains a major obstacle in the treatment of lung cancer, and its mechanism is still not fully elucidated. Meanwhile, CSCs have been involved in tumor metastasis, tumor recurrence and chemotherapy resistance. So far, the mechanism of nuclear enriched abundant transcript 1 (NEAT1) in modulating CSCs in lung cancer remains barely known. Therefore, we aimed to explore the correlation between NEAT1 and cancer stem cells in lung cancer. In our current study, we observed that CSC-like traits were much more enriched in cisplatin-resistant A549/CDDP cells. In addition, NEAT1 was obviously up-regulated in A549/CDDP cells compared with parental A549 cells. Knockdown of NEAT1 decreased the CSC-like properties of A549/CDDP cells through inhibiting tumor cell sphere volume, repressing CSC-like biomarkers levels and restraining CD44 positive cell ratios. Oppositely, overexpression of NEAT1 enhanced the stemness respectively. Moreover, it has been reported that Wnt pathway is implicated in many vital cellular functions including cancer stem cells. Here, it was exhibited that Wnt signal pathway was inactivated by knockdown of NEAT1 whereas activated by NEAT1 overexpression in A549/CDDP cells. Taken these together, it was indicated that NEAT1 could exert a novel biological role in NSCLC chemo-resistance." @default.
• W2894890140 created "2018-10-12" @default.
• W2894890140 creator A5006558974 @default.
• W2894890140 creator A5013433746 @default.
• W2894890140 creator A5015560678 @default.
• W2894890140 creator A5024144041 @default.
• W2894890140 creator A5036903229 @default.
• W2894890140 creator A5040020665 @default.
• W2894890140 creator A5050445168 @default.
• W2894890140 creator A5070080275 @default.
• W2894890140 creator A5080107420 @default.
• W2894890140 creator A5091722433 @default.
• W2894890140 date "2018-12-01" @default.
• W2894890140 modified "2023-10-12" @default.
• W2894890140 title "NEAT1 contributes to the CSC-like traits of A549/CDDP cells via activating Wnt signaling pathway" @default.
• W2894890140 cites W1414004483 @default.
• W2894890140 cites W1596453879 @default.
• W2894890140 cites W1911599821 @default.
• W2894890140 cites W1993002585 @default.
• W2894890140 cites W1996027069 @default.
• W2894890140 cites W2005977856 @default.
• W2894890140 cites W2007607256 @default.
• W2894890140 cites W2020486699 @default.
• W2894890140 cites W2049621625 @default.
• W2894890140 cites W2051197187 @default.
• W2894890140 cites W2058845478 @default.
• W2894890140 cites W2073793306 @default.
• W2894890140 cites W2087500600 @default.
• W2894890140 cites W2091829437 @default.
• W2894890140 cites W2096065464 @default.
• W2894890140 cites W2102085111 @default.
• W2894890140 cites W2107648723 @default.
• W2894890140 cites W2164159202 @default.
• W2894890140 cites W2167414381 @default.
• W2894890140 cites W2410407699 @default.
• W2894890140 cites W2507628504 @default.
• W2894890140 cites W2515678791 @default.
• W2894890140 cites W2517475579 @default.
• W2894890140 cites W2534024228 @default.
• W2894890140 cites W2550451908 @default.
• W2894890140 cites W2558017818 @default.
• W2894890140 cites W2589039930 @default.
• W2894890140 cites W2729481571 @default.
• W2894890140 cites W2755285110 @default.
• W2894890140 cites W2758746412 @default.
• W2894890140 cites W2767653597 @default.
• W2894890140 cites W2769937759 @default.
• W2894890140 cites W2770706758 @default.
• W2894890140 cites W2771418999 @default.
• W2894890140 cites W2781525129 @default.
• W2894890140 cites W2785608148 @default.
• W2894890140 cites W2793296540 @default.
• W2894890140 cites W2795034591 @default.
• W2894890140 cites W2804463612 @default.
• W2894890140 cites W2917837889 @default.
• W2894890140 doi "https://doi.org/10.1016/j.cbi.2018.10.001" @default.
• W2894890140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30291867" @default.
• W2894890140 hasPublicationYear "2018" @default.
• W2894890140 type Work @default.
• W2894890140 sameAs 2894890140 @default.
• W2894890140 citedByCount "22" @default.
• W2894890140 countsByYear W28948901402019 @default.
• W2894890140 countsByYear W28948901402020 @default.
• W2894890140 countsByYear W28948901402021 @default.
• W2894890140 countsByYear W28948901402022 @default.
• W2894890140 countsByYear W28948901402023 @default.
• W2894890140 crossrefType "journal-article" @default.
• W2894890140 hasAuthorship W2894890140A5006558974 @default.
• W2894890140 hasAuthorship W2894890140A5013433746 @default.
• W2894890140 hasAuthorship W2894890140A5015560678 @default.
• W2894890140 hasAuthorship W2894890140A5024144041 @default.
• W2894890140 hasAuthorship W2894890140A5036903229 @default.
• W2894890140 hasAuthorship W2894890140A5040020665 @default.
• W2894890140 hasAuthorship W2894890140A5050445168 @default.
• W2894890140 hasAuthorship W2894890140A5070080275 @default.
• W2894890140 hasAuthorship W2894890140A5080107420 @default.
• W2894890140 hasAuthorship W2894890140A5091722433 @default.
• W2894890140 hasConcept C121608353 @default.
• W2894890140 hasConcept C137620995 @default.
• W2894890140 hasConcept C143998085 @default.
• W2894890140 hasConcept C1491633281 @default.
• W2894890140 hasConcept C173396325 @default.
• W2894890140 hasConcept C185592680 @default.
• W2894890140 hasConcept C2776256026 @default.
• W2894890140 hasConcept C2776694085 @default.
• W2894890140 hasConcept C2778239845 @default.
• W2894890140 hasConcept C2780932548 @default.
• W2894890140 hasConcept C28328180 @default.
• W2894890140 hasConcept C502942594 @default.
• W2894890140 hasConcept C54355233 @default.
• W2894890140 hasConcept C55427017 @default.
• W2894890140 hasConcept C555283112 @default.
• W2894890140 hasConcept C62478195 @default.
• W2894890140 hasConcept C71924100 @default.
• W2894890140 hasConcept C81729549 @default.
• W2894890140 hasConcept C81885089 @default.
• W2894890140 hasConcept C86803240 @default.
• W2894890140 hasConcept C95444343 @default.

• next