FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894898104> ?p ?o ?g. }

• W2894898104 abstract "Radiation therapy is widely employed in the treatment of head and neck cancer. Adverse effects of therapeutic irradiation include delayed bone healing after dental extraction or impaired bone regeneration at the irradiated bony defect. Development of a reliable experimental model may be beneficial to study tissue regeneration in the irradiated field. The current study aimed to develop a relevant animal model of post-radiation cranial bone defect. A lead shielding block was designed for selective external irradiation of the mouse calvaria. Critical-size calvarial defect was created 2 weeks after the irradiation. The defect was filled with a collagen scaffold, with or without incorporation of bone morphogenetic protein 2 (BMP-2) (1 μg/ml). The non-irradiated mice treated with or without BMP-2-included scaffold served as control. Four weeks after the surgery, the specimens were harvested and the degree of bone formation was evaluated by histological and radiographical examinations. BMP-2-treated scaffold yielded significant bone regeneration in the mice calvarial defects. However, a single fraction of external irradiation was observed to eliminate the bone regeneration capacity of the BMP-2-incorporated scaffold without influencing the survival of the animals. The current study established an efficient model for post-radiation cranial bone regeneration and can be applied for evaluating the robust bone formation system using various chemokines or agents in unfavorable, demanding radiation-related bone defect models." @default.
• W2894898104 created "2018-10-12" @default.
• W2894898104 creator A5016460560 @default.
• W2894898104 creator A5021370060 @default.
• W2894898104 creator A5038313977 @default.
• W2894898104 creator A5040651191 @default.
• W2894898104 creator A5046565723 @default.
• W2894898104 date "2018-11-22" @default.
• W2894898104 modified "2023-10-17" @default.
• W2894898104 title "Development of an experimental model for radiation-induced inhibition of cranial bone regeneration" @default.
• W2894898104 cites W1896456932 @default.
• W2894898104 cites W1921998372 @default.
• W2894898104 cites W1964046496 @default.
• W2894898104 cites W1966269028 @default.
• W2894898104 cites W1968001906 @default.
• W2894898104 cites W1983325723 @default.
• W2894898104 cites W1985824800 @default.
• W2894898104 cites W1992618571 @default.
• W2894898104 cites W2006128895 @default.
• W2894898104 cites W2023333741 @default.
• W2894898104 cites W2023849520 @default.
• W2894898104 cites W2035350682 @default.
• W2894898104 cites W2039762221 @default.
• W2894898104 cites W2049948758 @default.
• W2894898104 cites W2070960271 @default.
• W2894898104 cites W2086431991 @default.
• W2894898104 cites W2088522861 @default.
• W2894898104 cites W2094147656 @default.
• W2894898104 cites W2096484869 @default.
• W2894898104 cites W2098731545 @default.
• W2894898104 cites W2110800021 @default.
• W2894898104 cites W2130927464 @default.
• W2894898104 cites W2131222823 @default.
• W2894898104 cites W2166827345 @default.
• W2894898104 cites W2179455240 @default.
• W2894898104 cites W2321237708 @default.
• W2894898104 cites W2332017824 @default.
• W2894898104 cites W2332883235 @default.
• W2894898104 cites W2403992849 @default.
• W2894898104 cites W2467292955 @default.
• W2894898104 cites W2487042194 @default.
• W2894898104 cites W2556495930 @default.
• W2894898104 doi "https://doi.org/10.1186/s40902-018-0173-1" @default.
• W2894898104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6249347" @default.
• W2894898104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30525010" @default.
• W2894898104 hasPublicationYear "2018" @default.
• W2894898104 type Work @default.
• W2894898104 sameAs 2894898104 @default.
• W2894898104 citedByCount "8" @default.
• W2894898104 countsByYear W28948981042019 @default.
• W2894898104 countsByYear W28948981042020 @default.
• W2894898104 countsByYear W28948981042021 @default.
• W2894898104 countsByYear W28948981042023 @default.
• W2894898104 crossrefType "journal-article" @default.
• W2894898104 hasAuthorship W2894898104A5016460560 @default.
• W2894898104 hasAuthorship W2894898104A5021370060 @default.
• W2894898104 hasAuthorship W2894898104A5038313977 @default.
• W2894898104 hasAuthorship W2894898104A5040651191 @default.
• W2894898104 hasAuthorship W2894898104A5046565723 @default.
• W2894898104 hasBestOaLocation W28948981041 @default.
• W2894898104 hasConcept C104317684 @default.
• W2894898104 hasConcept C105702510 @default.
• W2894898104 hasConcept C126322002 @default.
• W2894898104 hasConcept C136229726 @default.
• W2894898104 hasConcept C171056886 @default.
• W2894898104 hasConcept C202751555 @default.
• W2894898104 hasConcept C2779918246 @default.
• W2894898104 hasConcept C2991750140 @default.
• W2894898104 hasConcept C31507581 @default.
• W2894898104 hasConcept C55493867 @default.
• W2894898104 hasConcept C71924100 @default.
• W2894898104 hasConcept C8337478 @default.
• W2894898104 hasConcept C86803240 @default.
• W2894898104 hasConcept C89429830 @default.
• W2894898104 hasConcept C95444343 @default.
• W2894898104 hasConceptScore W2894898104C104317684 @default.
• W2894898104 hasConceptScore W2894898104C105702510 @default.
• W2894898104 hasConceptScore W2894898104C126322002 @default.
• W2894898104 hasConceptScore W2894898104C136229726 @default.
• W2894898104 hasConceptScore W2894898104C171056886 @default.
• W2894898104 hasConceptScore W2894898104C202751555 @default.
• W2894898104 hasConceptScore W2894898104C2779918246 @default.
• W2894898104 hasConceptScore W2894898104C2991750140 @default.
• W2894898104 hasConceptScore W2894898104C31507581 @default.
• W2894898104 hasConceptScore W2894898104C55493867 @default.
• W2894898104 hasConceptScore W2894898104C71924100 @default.
• W2894898104 hasConceptScore W2894898104C8337478 @default.
• W2894898104 hasConceptScore W2894898104C86803240 @default.
• W2894898104 hasConceptScore W2894898104C89429830 @default.
• W2894898104 hasConceptScore W2894898104C95444343 @default.
• W2894898104 hasFunder F4320322120 @default.
• W2894898104 hasIssue "1" @default.
• W2894898104 hasLocation W28948981041 @default.
• W2894898104 hasLocation W28948981042 @default.
• W2894898104 hasLocation W28948981043 @default.
• W2894898104 hasLocation W28948981044 @default.
• W2894898104 hasOpenAccess W2894898104 @default.
• W2894898104 hasPrimaryLocation W28948981041 @default.
• W2894898104 hasRelatedWork W1969532976 @default.
• W2894898104 hasRelatedWork W2038196160 @default.

• next