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• W2894900934 abstract "Abstract Reality monitoring is defined as the ability to distinguish internally self-generated information from externally-derived information. Functional imaging studies have consistently found that the medial prefrontal cortex (mPFC) is a key brain region subserving reality monitoring. The aim of this study was to determine a causal role for mPFC in reality monitoring using navigated repetitive transcranial magnetic stimulation (nrTMS). In a subject-blinded sham-controlled crossover design, healthy individuals received either active or sham nrTMS targeting mPFC. Active modulation of mPFC using nrTMS at a frequency of 10 Hz, significantly improved identification of both self-generated and externally-derived information during reality monitoring, when compared to sham or baseline. Targeted excitatory modulation of mPFC also improved positive mood ratings, reduced negative mood ratings and increased overall alertness/arousal. These results establish optimal nrTMS dosing parameters that maximized tolerability/comfort and induced significant neuromodulatory effects in the mPFC target. Importantly, this is a proof-of-concept study that establishes the mPFC as a novel brain target that can be stimulated with nrTMS to causally impact both mood and higher-order reality monitoring." @default.
• W2894900934 created "2018-10-12" @default.
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• W2894900934 date "2018-10-07" @default.
• W2894900934 modified "2023-09-27" @default.
• W2894900934 title "Establishing a causal role for medial prefrontal cortex in reality monitoring" @default.
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• W2894900934 doi "https://doi.org/10.1101/436907" @default.
• W2894900934 hasPublicationYear "2018" @default.
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