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- W2894901153 abstract "Traditional medicine is an important source for drug discovery. However, many challenges face the scientific community to develop novel drugs from it. To investigate the rationale behind the medical legacy of centuries of precious knowledge from traditional medicine, we aimed at performing virtual screening to identify potential leads from the middle-age textbook, The Canon of Medicine.A database of chemical constituents of plants mentioned within the book was built and docked against different molecular targets associated with inflammation such as phospholipase A2, p38 alpha mitogen activated protein kinase, cyclooxygenase-2 and leukotriene B4 dehydrogenase, after that literature survey was done to determine the consistency of traditional uses and molecular docking results with the current knowledge obtained from previous studies and reports.The in-silico study revealed the ability of several chemical constituents, in the plants under investigation, to bind effectively to different targets associated with inflammation, which was consistent with previous reports, indicating that Islamic traditional medicine can be considered as a reliable promising source for developing new anti-inflammatory agents with low toxicity and minimal side effects." @default.
- W2894901153 created "2018-10-12" @default.
- W2894901153 creator A5006546979 @default.
- W2894901153 creator A5078211047 @default.
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- W2894901153 date "2019-10-01" @default.
- W2894901153 modified "2023-09-24" @default.
- W2894901153 title "Insights on the molecular mechanism of anti-inflammatory effect of formula from Islamic traditional medicine: An in-silico study" @default.
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- W2894901153 doi "https://doi.org/10.1016/j.jtcme.2018.09.004" @default.
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