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- W2894901498 abstract "Research question Does regular smoking affect semen quality and the levels of DNA methylation in mature human spermatozoa? Design Spermatozoa from 109 men were evaluated (55 smokers and 54 non-smokers). DNA was extracted from purified spermatozoa, and DNA methylation was quantified by enzyme-linked immunosorbent assay (ELISA). Results Global DNA methylation of non-smokers is significantly lower (P < 0.001) than that of smokers (4.85 ± 2.72 and 7.08 ± 1.77 ng/μl, respectively). Moreover, the mean global DNA methylation levels were significantly correlated (r = 0.22;P = 0.02) with non-condensed chromatin in the spermatozoa. Levels of non-condensed chromatin were significantly higher (P < 0.001) in smokers (29.75 ± 9.38%) compared with non-smokers (20.96 ± 11.31%). Furthermore, global sperm DNA methylation was negatively correlated with high significance (P < 0.010) with sperm: count (r = –0.27), motility (r = –0.30) and vitality (r = –0.26). Conclusion Smoking interferes with DNA methylation. Also, DNA methylation is significantly correlated with sperm parameters and sperm non-condensed chromatin. These data emphasize another detrimental effect of smoking on male fertility. DNA methylation may, therefore, be considered as a fertility marker in men." @default.
- W2894901498 created "2018-10-12" @default.
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- W2894901498 date "2018-11-01" @default.
- W2894901498 modified "2023-10-14" @default.
- W2894901498 title "The status of global DNA methylation in the spermatozoa of smokers and non-smokers" @default.
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- W2894901498 doi "https://doi.org/10.1016/j.rbmo.2018.08.016" @default.
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