FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894906387> ?p ?o ?g. }

• W2894906387 endingPage "F1832" @default.
• W2894906387 startingPage "F1822" @default.
• W2894906387 abstract "Renal fibrosis is a common pathological feature in chronic kidney disease (CKD), including diabetic kidney disease (DKD) and obstructive nephropathy. Multiple microRNAs have been implicated in the pathogenesis of both DKD and obstructive nephropathy, although the overall role of microRNAs in tubular injury and renal fibrosis in CKD is unclear. Dicer (a key RNase III enzyme for microRNA biogenesis) was specifically ablated from kidney proximal tubules in mice via the Cre-lox system to deplete micoRNAs. Proximal tubular Dicer knockout (PT- Dicer KO) mice and wild-type (WT) littermates were subjected to streptozotocin (STZ) treatment to induce DKD or unilateral ureteral obstruction (UUO) to induce obstructive nephropathy. Renal hypertrophy, renal tubular apoptosis, kidney inflammation, and tubulointerstitial fibrosis were examined. Compared with WT mice, PT- Dicer KO mice showed more severe tubular injury and renal inflammation following STZ treatment. These mice also developed higher levels of tubolointerstitial fibrosis. Meanwhile, PT- Dicer KO mice had a significantly higher Smad2/3 expression in kidneys than WT mice (at 6 mo of age) in both control and STZ-treated mice. Similarly, UUO induced more severe renal injury, inflammation, and interstitial fibrosis in PT- Dicer KO mice than WT. Although we did not detect obvious Smad2/3 expression in sham-operated mice (2–3 mo old), significantly more Smad2/3 was induced in obstructed PT- Dicer KO kidneys. These results supported a protective role of Dicer-dependent microRNA synthesis in renal injury and fibrosis development in CKD, specifically in DKD and obstructive nephropathy. Depletion of Dicer and microRNAs may upregulate Smad2/3-related signaling pathway to enhance the progression of CKD." @default.
• W2894906387 created "2018-10-12" @default.
• W2894906387 creator A5002687021 @default.
• W2894906387 creator A5021412775 @default.
• W2894906387 creator A5045421676 @default.
• W2894906387 creator A5050155862 @default.
• W2894906387 creator A5050492383 @default.
• W2894906387 date "2018-12-01" @default.
• W2894906387 modified "2023-10-11" @default.
• W2894906387 title "Dicer deficiency in proximal tubules exacerbates renal injury and tubulointerstitial fibrosis and upregulates Smad2/3" @default.
• W2894906387 cites W1164462559 @default.
• W2894906387 cites W1487421873 @default.
• W2894906387 cites W1579574489 @default.
• W2894906387 cites W1963864987 @default.
• W2894906387 cites W1972962169 @default.
• W2894906387 cites W1978338530 @default.
• W2894906387 cites W1992425189 @default.
• W2894906387 cites W1992779719 @default.
• W2894906387 cites W1996046117 @default.
• W2894906387 cites W1996351224 @default.
• W2894906387 cites W1997088049 @default.
• W2894906387 cites W2001045885 @default.
• W2894906387 cites W2010907636 @default.
• W2894906387 cites W2016865792 @default.
• W2894906387 cites W2022617421 @default.
• W2894906387 cites W2028849772 @default.
• W2894906387 cites W2044747742 @default.
• W2894906387 cites W2061433584 @default.
• W2894906387 cites W2061477448 @default.
• W2894906387 cites W2063404839 @default.
• W2894906387 cites W2076100820 @default.
• W2894906387 cites W2097628596 @default.
• W2894906387 cites W2100125827 @default.
• W2894906387 cites W2102895846 @default.
• W2894906387 cites W2104274897 @default.
• W2894906387 cites W2107724630 @default.
• W2894906387 cites W2124502714 @default.
• W2894906387 cites W2135580384 @default.
• W2894906387 cites W2138991213 @default.
• W2894906387 cites W2149586549 @default.
• W2894906387 cites W2150572884 @default.
• W2894906387 cites W2154258399 @default.
• W2894906387 cites W2156808480 @default.
• W2894906387 cites W2170639077 @default.
• W2894906387 cites W2170961031 @default.
• W2894906387 cites W2179401868 @default.
• W2894906387 cites W2182856316 @default.
• W2894906387 cites W2230956746 @default.
• W2894906387 cites W2253220599 @default.
• W2894906387 cites W2290307663 @default.
• W2894906387 cites W2295481932 @default.
• W2894906387 cites W2333727147 @default.
• W2894906387 cites W2342679639 @default.
• W2894906387 cites W2342967374 @default.
• W2894906387 cites W2399361349 @default.
• W2894906387 cites W2513784412 @default.
• W2894906387 cites W2517894941 @default.
• W2894906387 cites W2556247569 @default.
• W2894906387 cites W2568946527 @default.
• W2894906387 cites W2570430303 @default.
• W2894906387 cites W2581025349 @default.
• W2894906387 cites W2589878294 @default.
• W2894906387 cites W2735368759 @default.
• W2894906387 cites W2737074341 @default.
• W2894906387 cites W2758043862 @default.
• W2894906387 cites W2760305366 @default.
• W2894906387 cites W2767391725 @default.
• W2894906387 cites W2772835488 @default.
• W2894906387 cites W2789927805 @default.
• W2894906387 cites W2790571799 @default.
• W2894906387 cites W2792844735 @default.
• W2894906387 cites W2793109478 @default.
• W2894906387 cites W2793511083 @default.
• W2894906387 cites W2796627206 @default.
• W2894906387 cites W2801861592 @default.
• W2894906387 cites W2805093935 @default.
• W2894906387 cites W2807319243 @default.
• W2894906387 cites W2809754002 @default.
• W2894906387 cites W2963097993 @default.
• W2894906387 doi "https://doi.org/10.1152/ajprenal.00402.2018" @default.
• W2894906387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6337000" @default.
• W2894906387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30280598" @default.
• W2894906387 hasPublicationYear "2018" @default.
• W2894906387 type Work @default.
• W2894906387 sameAs 2894906387 @default.
• W2894906387 citedByCount "12" @default.
• W2894906387 countsByYear W28949063872019 @default.
• W2894906387 countsByYear W28949063872020 @default.
• W2894906387 countsByYear W28949063872021 @default.
• W2894906387 countsByYear W28949063872022 @default.
• W2894906387 countsByYear W28949063872023 @default.
• W2894906387 crossrefType "journal-article" @default.
• W2894906387 hasAuthorship W2894906387A5002687021 @default.
• W2894906387 hasAuthorship W2894906387A5021412775 @default.
• W2894906387 hasAuthorship W2894906387A5045421676 @default.
• W2894906387 hasAuthorship W2894906387A5050155862 @default.
• W2894906387 hasAuthorship W2894906387A5050492383 @default.
• W2894906387 hasBestOaLocation W28949063871 @default.

• next