FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894908652> ?p ?o ?g. }

• W2894908652 endingPage "173" @default.
• W2894908652 startingPage "164" @default.
• W2894908652 abstract "Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease affecting exocrine glands, thereby causing dry mouth and eyes (sicca). Our objective was to determine the expression of pSS pathogenic biomarker MMP9 and its putative transcription factors ETS1 and LEF1, in labial salivary glands of pSS patients.Sicca patients were assigned to three groups based on focus score (FS): non-pSS sicca (i.e., GR1 [FS = 0] and GR2 [0 < FS < 1]) and pSS (i.e., GR3 [FS ≥ 1]). We determined the mRNA and protein expression of MMP9, ETS1, and LEF1 in salivary gland biopsies. Also, ETS1-CD4 and LEF1-CD4 co-expression analyses were performed.The mRNA expression of MMP9, ETS1, and LEF1 was upregulated in GR3 compared to GR1 (p < 0.01). Most GR3 salivary gland areas had moderate to high MMP9, ETS1, and LEF1 protein expression compared to GR1 and GR2. Further, ETS1-CD4 and LEF1-CD4 dual staining demonstrated that both salivary gland epithelial cells and lymphocytic infiltrates had increased levels of ETS1 and LEF1. Moreover, there was a strong correlation between ETS1(+)-CD4(-) and LEF1(+)-CD4(-) cells.These results suggest, for the first time, a concerted increase in ETS1 and LEF1 expression in salivary gland epithelial cells of pSS patients that is reflective of the etiopathogenesis of pSS." @default.
• W2894908652 created "2018-10-12" @default.
• W2894908652 creator A5004946116 @default.
• W2894908652 creator A5007532476 @default.
• W2894908652 creator A5021451804 @default.
• W2894908652 creator A5022688933 @default.
• W2894908652 creator A5033374698 @default.
• W2894908652 creator A5069255124 @default.
• W2894908652 date "2018-10-22" @default.
• W2894908652 modified "2023-10-14" @default.
• W2894908652 title "Expression of ETS1 and LEF1 in salivary glands of Sjögren syndrome patients" @default.
• W2894908652 cites W1965103667 @default.
• W2894908652 cites W1975305533 @default.
• W2894908652 cites W1989617933 @default.
• W2894908652 cites W2012173046 @default.
• W2894908652 cites W2018964908 @default.
• W2894908652 cites W2030027161 @default.
• W2894908652 cites W2030711090 @default.
• W2894908652 cites W2050991236 @default.
• W2894908652 cites W2057829700 @default.
• W2894908652 cites W2060949390 @default.
• W2894908652 cites W2063368491 @default.
• W2894908652 cites W2084094826 @default.
• W2894908652 cites W2112825838 @default.
• W2894908652 cites W2113794594 @default.
• W2894908652 cites W2116134336 @default.
• W2894908652 cites W2118065323 @default.
• W2894908652 cites W2120282676 @default.
• W2894908652 cites W2135092690 @default.
• W2894908652 cites W2159297987 @default.
• W2894908652 cites W2475759678 @default.
• W2894908652 cites W2520558036 @default.
• W2894908652 cites W2608120573 @default.
• W2894908652 cites W2750100642 @default.
• W2894908652 cites W2767285201 @default.
• W2894908652 cites W2783682049 @default.
• W2894908652 cites W2795536459 @default.
• W2894908652 cites W3022289262 @default.
• W2894908652 doi "https://doi.org/10.1111/odi.12985" @default.
• W2894908652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30270548" @default.
• W2894908652 hasPublicationYear "2018" @default.
• W2894908652 type Work @default.
• W2894908652 sameAs 2894908652 @default.
• W2894908652 citedByCount "3" @default.
• W2894908652 countsByYear W28949086522018 @default.
• W2894908652 countsByYear W28949086522019 @default.
• W2894908652 countsByYear W28949086522022 @default.
• W2894908652 crossrefType "journal-article" @default.
• W2894908652 hasAuthorship W2894908652A5004946116 @default.
• W2894908652 hasAuthorship W2894908652A5007532476 @default.
• W2894908652 hasAuthorship W2894908652A5021451804 @default.
• W2894908652 hasAuthorship W2894908652A5022688933 @default.
• W2894908652 hasAuthorship W2894908652A5033374698 @default.
• W2894908652 hasAuthorship W2894908652A5069255124 @default.
• W2894908652 hasBestOaLocation W28949086521 @default.
• W2894908652 hasConcept C104317684 @default.
• W2894908652 hasConcept C126322002 @default.
• W2894908652 hasConcept C127561419 @default.
• W2894908652 hasConcept C142724271 @default.
• W2894908652 hasConcept C2775997469 @default.
• W2894908652 hasConcept C2778937882 @default.
• W2894908652 hasConcept C2780538058 @default.
• W2894908652 hasConcept C2781197716 @default.
• W2894908652 hasConcept C55493867 @default.
• W2894908652 hasConcept C71924100 @default.
• W2894908652 hasConcept C86339819 @default.
• W2894908652 hasConcept C86803240 @default.
• W2894908652 hasConceptScore W2894908652C104317684 @default.
• W2894908652 hasConceptScore W2894908652C126322002 @default.
• W2894908652 hasConceptScore W2894908652C127561419 @default.
• W2894908652 hasConceptScore W2894908652C142724271 @default.
• W2894908652 hasConceptScore W2894908652C2775997469 @default.
• W2894908652 hasConceptScore W2894908652C2778937882 @default.
• W2894908652 hasConceptScore W2894908652C2780538058 @default.
• W2894908652 hasConceptScore W2894908652C2781197716 @default.
• W2894908652 hasConceptScore W2894908652C55493867 @default.
• W2894908652 hasConceptScore W2894908652C71924100 @default.
• W2894908652 hasConceptScore W2894908652C86339819 @default.
• W2894908652 hasConceptScore W2894908652C86803240 @default.
• W2894908652 hasIssue "1" @default.
• W2894908652 hasLocation W28949086521 @default.
• W2894908652 hasLocation W28949086522 @default.
• W2894908652 hasOpenAccess W2894908652 @default.
• W2894908652 hasPrimaryLocation W28949086521 @default.
• W2894908652 hasRelatedWork W2020449916 @default.
• W2894908652 hasRelatedWork W2079070424 @default.
• W2894908652 hasRelatedWork W2083502042 @default.
• W2894908652 hasRelatedWork W2126616111 @default.
• W2894908652 hasRelatedWork W2126730073 @default.
• W2894908652 hasRelatedWork W2160940770 @default.
• W2894908652 hasRelatedWork W2415143265 @default.
• W2894908652 hasRelatedWork W2793239644 @default.
• W2894908652 hasRelatedWork W2894908652 @default.
• W2894908652 hasRelatedWork W2923451033 @default.
• W2894908652 hasVolume "25" @default.
• W2894908652 isParatext "false" @default.
• W2894908652 isRetracted "false" @default.
• W2894908652 magId "2894908652" @default.

• next