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• W2894915930 abstract "Background & Aims: This observational retrospective study aimed at evaluating the effects of one-year administrationof homotaurine (tramiprosate) in a sample patients presenting with symptoms of mild cognitiveimpairment.Methods: Patient’s demographic data and medical history are reported. Each patient performed brain imagingand neuropsychological assessment to reach the diagnosis. Each patient assumed 100 mg total dose ofhomotaurine/day. The evolution of the cognitive decline over time was evaluated my means of the Mini MentalState Examination (MMSE).Results: 245 patients from 28 different centres in Italy were recruited. Significant improvements from baselineexpressed as mean MMSE total score were observed in patients with aMCI at months 8 and 12 (p < 0.0001),and in those with mMCI at month 4 (p < 0.05).Conclusions: Administration of homotaurine revealed beneficial effects in our sample population of MCI patients.Our results indicate clearly that homotaurine may well be considered as a potential symptomatic treatmentfor cognitive symptoms. Further research is however needed to clarify whether this compound couldinfluence the progression of cognitive decline." @default.
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• W2894915930 date "2018-01-01" @default.
• W2894915930 modified "2023-09-27" @default.
• W2894915930 title "Effect of homotaurine in patients with cognitive impairment: Results from an Italian observational retrospective study" @default.
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