Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894918056> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2894918056 endingPage "16" @default.
- W2894918056 startingPage "12" @default.
- W2894918056 abstract "The survival of patients even with disseminated disease reached 7–8 years after introduction of imatinib and sunitinib for the treatment of gastrointestinal stromal tumours (GIST) into everyday clinical practice. These drugs efficacy is largely determined by the presence and any mutations of C-KIT and PDGFR genes. It was established that new mutations appear in most tumours against the background of tyrosine kinase inhibitors therapy, which causes the development of secondary resistance and the progression of the disease in most cases. The search for opportunities to overcome the newly developed or initially existing resistance caused by different gene mutations continues to be of vital importance. One of such drugs is regorafenib, which has demonstrated antitumour activity against progression on imatinib and/or sunitinib. The paper reviews the studies of the efficacy of regoraphanib in patients with disseminated GIST, taking into account the presence and any mutations of C-KIT and PDGFR genes, and presents a description of their own clinical case of prolonged use of the drug in a patient who have received earlier both imatinib and sunitinib." @default.
- W2894918056 created "2018-10-12" @default.
- W2894918056 creator A5012011624 @default.
- W2894918056 creator A5059793527 @default.
- W2894918056 creator A5061751722 @default.
- W2894918056 creator A5072874237 @default.
- W2894918056 creator A5084987665 @default.
- W2894918056 creator A5086834758 @default.
- W2894918056 creator A5087082454 @default.
- W2894918056 date "2018-07-19" @default.
- W2894918056 modified "2023-09-27" @default.
- W2894918056 title "The use of regorafenib in patients with disseminated gastrointestinal stromal tumours. A review of the literature. A clinical case" @default.
- W2894918056 cites W2116922255 @default.
- W2894918056 cites W2132190370 @default.
- W2894918056 cites W2167121383 @default.
- W2894918056 cites W2461823061 @default.
- W2894918056 cites W2607491338 @default.
- W2894918056 doi "https://doi.org/10.21518/2079-701x-2018-10-12-16" @default.
- W2894918056 hasPublicationYear "2018" @default.
- W2894918056 type Work @default.
- W2894918056 sameAs 2894918056 @default.
- W2894918056 citedByCount "0" @default.
- W2894918056 crossrefType "journal-article" @default.
- W2894918056 hasAuthorship W2894918056A5012011624 @default.
- W2894918056 hasAuthorship W2894918056A5059793527 @default.
- W2894918056 hasAuthorship W2894918056A5061751722 @default.
- W2894918056 hasAuthorship W2894918056A5072874237 @default.
- W2894918056 hasAuthorship W2894918056A5084987665 @default.
- W2894918056 hasAuthorship W2894918056A5086834758 @default.
- W2894918056 hasAuthorship W2894918056A5087082454 @default.
- W2894918056 hasBestOaLocation W28949180561 @default.
- W2894918056 hasConcept C114851261 @default.
- W2894918056 hasConcept C121608353 @default.
- W2894918056 hasConcept C126322002 @default.
- W2894918056 hasConcept C143998085 @default.
- W2894918056 hasConcept C16930146 @default.
- W2894918056 hasConcept C2775922572 @default.
- W2894918056 hasConcept C2776248978 @default.
- W2894918056 hasConcept C2777007597 @default.
- W2894918056 hasConcept C2777583451 @default.
- W2894918056 hasConcept C2778729363 @default.
- W2894918056 hasConcept C2778820342 @default.
- W2894918056 hasConcept C2779134260 @default.
- W2894918056 hasConcept C2779490328 @default.
- W2894918056 hasConcept C2781230642 @default.
- W2894918056 hasConcept C3019892230 @default.
- W2894918056 hasConcept C502942594 @default.
- W2894918056 hasConcept C526805850 @default.
- W2894918056 hasConcept C54355233 @default.
- W2894918056 hasConcept C71924100 @default.
- W2894918056 hasConcept C86803240 @default.
- W2894918056 hasConceptScore W2894918056C114851261 @default.
- W2894918056 hasConceptScore W2894918056C121608353 @default.
- W2894918056 hasConceptScore W2894918056C126322002 @default.
- W2894918056 hasConceptScore W2894918056C143998085 @default.
- W2894918056 hasConceptScore W2894918056C16930146 @default.
- W2894918056 hasConceptScore W2894918056C2775922572 @default.
- W2894918056 hasConceptScore W2894918056C2776248978 @default.
- W2894918056 hasConceptScore W2894918056C2777007597 @default.
- W2894918056 hasConceptScore W2894918056C2777583451 @default.
- W2894918056 hasConceptScore W2894918056C2778729363 @default.
- W2894918056 hasConceptScore W2894918056C2778820342 @default.
- W2894918056 hasConceptScore W2894918056C2779134260 @default.
- W2894918056 hasConceptScore W2894918056C2779490328 @default.
- W2894918056 hasConceptScore W2894918056C2781230642 @default.
- W2894918056 hasConceptScore W2894918056C3019892230 @default.
- W2894918056 hasConceptScore W2894918056C502942594 @default.
- W2894918056 hasConceptScore W2894918056C526805850 @default.
- W2894918056 hasConceptScore W2894918056C54355233 @default.
- W2894918056 hasConceptScore W2894918056C71924100 @default.
- W2894918056 hasConceptScore W2894918056C86803240 @default.
- W2894918056 hasIssue "10" @default.
- W2894918056 hasLocation W28949180561 @default.
- W2894918056 hasOpenAccess W2894918056 @default.
- W2894918056 hasPrimaryLocation W28949180561 @default.
- W2894918056 hasRelatedWork W2044711703 @default.
- W2894918056 hasRelatedWork W2079642245 @default.
- W2894918056 hasRelatedWork W2515688311 @default.
- W2894918056 hasRelatedWork W2610834551 @default.
- W2894918056 hasRelatedWork W2754132767 @default.
- W2894918056 hasRelatedWork W2800718089 @default.
- W2894918056 hasRelatedWork W2887650551 @default.
- W2894918056 hasRelatedWork W2936089150 @default.
- W2894918056 hasRelatedWork W3010471422 @default.
- W2894918056 hasRelatedWork W4313646442 @default.
- W2894918056 isParatext "false" @default.
- W2894918056 isRetracted "false" @default.
- W2894918056 magId "2894918056" @default.
- W2894918056 workType "article" @default.