FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894922295> ?p ?o ?g. }

• W2894922295 endingPage "612" @default.
• W2894922295 startingPage "601" @default.
• W2894922295 abstract "Research question We recently reported that blocking of placental aquaporins (AQP) abrogates the apoptotic response of the trophoblast. As trophoblast apoptosis is exacerbated in pre-eclampsia, we hypothesized that changes in AQP in these placentae may trigger programmed cell death. We analysed AQP4 expression in pre-eclamptic placentae and its regulation by oxygen tension. Design AQP4 expression was studied in placentae from non-pathological and pre-eclamptic pregnancies by reverse transcription polymerase chain reaction (RT-PCR), Western blot, immunofluorescence and immunohistochemistry. Explants from non-pathological placentae were cultured in normoxia, hypoxia, hypoxia–reoxygenation and CoCl2. AQP4 expression was investigated by RT-PCR and Western blot. Hypoxia responsive elements sites on AQP4 promotor were investigated by in-silico analysis. AQP4 degradation was studied in the presence of proteosomal and lysosomal inhibitors. Results AQP4 protein expression was weakly detectable in pre-eclamptic placentae, but its mRNA was elevated compared with non-pathological placentae. In non-pathological explants cultured in hypoxia, AQP4 mRNA and protein were increased compared with placentae cultured in ambient oxygen but decreased after reoxygenation. Incubation with CoCl2, that stabilizes hypoxia inducible factor (HIF)-1α, also increased AQP4 levels. In-silico analysis showed three putative binding sites for HIF-1α in AQP4 promotor. Conclusions Oxygen may regulate AQP4 expression in human placenta, possibly through HIF-1α. Therefore, the decrease in AQP4 throughout pregnancy, previously reported, is consistent with changes in HIF-1α, and suggests that AQP4 might have a crucial role during placentation. Therefore, the abnormal expression of AQP4 may be involved in the cause of pre-eclampsia, but it does not seem to take part in the apoptotic events." @default.
• W2894922295 created "2018-10-12" @default.
• W2894922295 creator A5010007659 @default.
• W2894922295 creator A5039500138 @default.
• W2894922295 creator A5041697119 @default.
• W2894922295 creator A5058071916 @default.
• W2894922295 creator A5068577989 @default.
• W2894922295 creator A5077165427 @default.
• W2894922295 creator A5080507972 @default.
• W2894922295 date "2018-11-01" @default.
• W2894922295 modified "2023-09-26" @default.
• W2894922295 title "Oxygen regulation of aquaporin-4 in human placenta" @default.
• W2894922295 cites W1151864206 @default.
• W2894922295 cites W1552761384 @default.
• W2894922295 cites W1845114139 @default.
• W2894922295 cites W1910833807 @default.
• W2894922295 cites W194359172 @default.
• W2894922295 cites W1964486235 @default.
• W2894922295 cites W1965204440 @default.
• W2894922295 cites W1971576406 @default.
• W2894922295 cites W1972766975 @default.
• W2894922295 cites W1975517087 @default.
• W2894922295 cites W1994287995 @default.
• W2894922295 cites W1999967082 @default.
• W2894922295 cites W2003878821 @default.
• W2894922295 cites W2004416362 @default.
• W2894922295 cites W2009650337 @default.
• W2894922295 cites W2014399551 @default.
• W2894922295 cites W2034052118 @default.
• W2894922295 cites W2037121410 @default.
• W2894922295 cites W2047868879 @default.
• W2894922295 cites W2052072405 @default.
• W2894922295 cites W2052163433 @default.
• W2894922295 cites W2053236906 @default.
• W2894922295 cites W2058795973 @default.
• W2894922295 cites W2071353142 @default.
• W2894922295 cites W2072756039 @default.
• W2894922295 cites W2073204295 @default.
• W2894922295 cites W2078000972 @default.
• W2894922295 cites W2078594307 @default.
• W2894922295 cites W2091003012 @default.
• W2894922295 cites W2113809450 @default.
• W2894922295 cites W2125313335 @default.
• W2894922295 cites W2135401734 @default.
• W2894922295 cites W2141528928 @default.
• W2894922295 cites W2146405207 @default.
• W2894922295 cites W2153550523 @default.
• W2894922295 cites W2165954309 @default.
• W2894922295 cites W2167898988 @default.
• W2894922295 cites W2215279020 @default.
• W2894922295 cites W2253702168 @default.
• W2894922295 cites W2462515806 @default.
• W2894922295 cites W2492734371 @default.
• W2894922295 cites W2759350164 @default.
• W2894922295 cites W3022171609 @default.
• W2894922295 cites W4233842380 @default.
• W2894922295 doi "https://doi.org/10.1016/j.rbmo.2018.08.015" @default.
• W2894922295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30539720" @default.
• W2894922295 hasPublicationYear "2018" @default.
• W2894922295 type Work @default.
• W2894922295 sameAs 2894922295 @default.
• W2894922295 citedByCount "9" @default.
• W2894922295 countsByYear W28949222952020 @default.
• W2894922295 countsByYear W28949222952021 @default.
• W2894922295 countsByYear W28949222952022 @default.
• W2894922295 countsByYear W28949222952023 @default.
• W2894922295 crossrefType "journal-article" @default.
• W2894922295 hasAuthorship W2894922295A5010007659 @default.
• W2894922295 hasAuthorship W2894922295A5039500138 @default.
• W2894922295 hasAuthorship W2894922295A5041697119 @default.
• W2894922295 hasAuthorship W2894922295A5058071916 @default.
• W2894922295 hasAuthorship W2894922295A5068577989 @default.
• W2894922295 hasAuthorship W2894922295A5077165427 @default.
• W2894922295 hasAuthorship W2894922295A5080507972 @default.
• W2894922295 hasConcept C104317684 @default.
• W2894922295 hasConcept C127413603 @default.
• W2894922295 hasConcept C153911025 @default.
• W2894922295 hasConcept C15755913 @default.
• W2894922295 hasConcept C16685009 @default.
• W2894922295 hasConcept C172680121 @default.
• W2894922295 hasConcept C177586851 @default.
• W2894922295 hasConcept C178790620 @default.
• W2894922295 hasConcept C185592680 @default.
• W2894922295 hasConcept C190283241 @default.
• W2894922295 hasConcept C201289731 @default.
• W2894922295 hasConcept C2775845273 @default.
• W2894922295 hasConcept C2776415932 @default.
• W2894922295 hasConcept C2776953305 @default.
• W2894922295 hasConcept C2777495146 @default.
• W2894922295 hasConcept C2779234561 @default.
• W2894922295 hasConcept C540031477 @default.
• W2894922295 hasConcept C54355233 @default.
• W2894922295 hasConcept C55493867 @default.
• W2894922295 hasConcept C71924100 @default.
• W2894922295 hasConcept C7836513 @default.
• W2894922295 hasConcept C78519656 @default.
• W2894922295 hasConcept C86803240 @default.
• W2894922295 hasConceptScore W2894922295C104317684 @default.

• next