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- W2894924203 abstract "The actin cytoskeleton comprises a set of filament networks that perform essential functions in eukaryotic cells. The idea that actin filaments incorporate monomers directly from solution forms both the “textbook picture” of filament elongation and a conventional starting point for quantitative modeling of cellular actin dynamics. Recent work, however, reveals that filaments created by two major regulators, the formins and the Arp2/3 complex, incorporate monomers delivered by nearby proteins. Specifically, actin enters Arp2/3-generated networks via binding sites on nucleation-promoting factors clustered on membrane surfaces. Here, we describe three functions of this surface-associated actin monomer pool: (1) regulating network density via product inhibition of the Arp2/3 complex, (2) accelerating filament elongation as a distributive polymerase, and (3) converting profilin-actin into a substrate for the Arp2/3 complex. These linked functions control the architecture of branched networks and explain how capping protein enhances their growth." @default.
- W2894924203 created "2018-10-12" @default.
- W2894924203 creator A5018413012 @default.
- W2894924203 creator A5027559931 @default.
- W2894924203 creator A5084102341 @default.
- W2894924203 date "2018-11-23" @default.
- W2894924203 modified "2023-10-01" @default.
- W2894924203 title "From solution to surface to filament: actin flux into branched networks" @default.
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- W2894924203 doi "https://doi.org/10.1007/s12551-018-0469-5" @default.
- W2894924203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6297094" @default.
- W2894924203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30470968" @default.
- W2894924203 hasPublicationYear "2018" @default.
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