Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894925291> ?p ?o ?g. }
- W2894925291 abstract "Abstract The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to implement tri-methylation of histone H3 Ly4 (H3K4me3). Although H3K4me3 is widely associated with gene expression, the effects of CFP1 loss depend on chromatin context, so it is important to understand the relationship between CFP1 and other chromatin factors. Using a proteomics approach, we identified an unexpected link between C. elegans CFP-1 and a Rpd3/Sin3 histone deacetylase complex. We find that mutants of CFP-1, SIN-3, and the catalytic subunit SET-2/SET1 have similar phenotypes and misregulate common genes. CFP-1 directly binds SIN-3 through a region including the conserved PAH1 domain and recruits SIN-3 and the HDA-1/HDAC subunit to H3K4me3 enriched promoters. Our results reveal a novel role for CFP-1 in mediating interaction between SET1/COMPASS and a Sin3 HDAC complex at promoters and uncover coordinate regulation of gene expression by chromatin complexes having distinct activities." @default.
- W2894925291 created "2018-10-12" @default.
- W2894925291 creator A5005451961 @default.
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- W2894925291 creator A5090866168 @default.
- W2894925291 date "2018-10-05" @default.
- W2894925291 modified "2023-10-18" @default.
- W2894925291 title "Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3 HDAC complex" @default.
- W2894925291 cites W1488701566 @default.
- W2894925291 cites W1656496643 @default.
- W2894925291 cites W1827528520 @default.
- W2894925291 cites W1892124455 @default.
- W2894925291 cites W1892901389 @default.
- W2894925291 cites W1895656080 @default.
- W2894925291 cites W1965343063 @default.
- W2894925291 cites W1968603229 @default.
- W2894925291 cites W1969575940 @default.
- W2894925291 cites W1976857485 @default.
- W2894925291 cites W1977170578 @default.
- W2894925291 cites W1977186059 @default.
- W2894925291 cites W1978211526 @default.
- W2894925291 cites W1981516407 @default.
- W2894925291 cites W1981620468 @default.
- W2894925291 cites W1985724808 @default.
- W2894925291 cites W1988650678 @default.
- W2894925291 cites W1991475922 @default.
- W2894925291 cites W1992662525 @default.
- W2894925291 cites W1996868531 @default.
- W2894925291 cites W2001360952 @default.
- W2894925291 cites W2003053220 @default.
- W2894925291 cites W2007684630 @default.
- W2894925291 cites W2007977711 @default.
- W2894925291 cites W2008625770 @default.
- W2894925291 cites W2009572165 @default.
- W2894925291 cites W2010291571 @default.
- W2894925291 cites W2010820968 @default.
- W2894925291 cites W2012606436 @default.
- W2894925291 cites W2018039678 @default.
- W2894925291 cites W2018742603 @default.
- W2894925291 cites W2025836692 @default.
- W2894925291 cites W2026720950 @default.
- W2894925291 cites W2030043909 @default.
- W2894925291 cites W2030427461 @default.
- W2894925291 cites W2030430240 @default.
- W2894925291 cites W2030823261 @default.
- W2894925291 cites W2032736838 @default.
- W2894925291 cites W2032859562 @default.
- W2894925291 cites W2033307196 @default.
- W2894925291 cites W2041652724 @default.
- W2894925291 cites W2042584499 @default.
- W2894925291 cites W2047343415 @default.
- W2894925291 cites W2048186818 @default.
- W2894925291 cites W2050189729 @default.
- W2894925291 cites W2053408851 @default.
- W2894925291 cites W2053753978 @default.
- W2894925291 cites W2053964757 @default.
- W2894925291 cites W2054205113 @default.
- W2894925291 cites W2059004178 @default.
- W2894925291 cites W2060958959 @default.
- W2894925291 cites W2063071041 @default.
- W2894925291 cites W2067606904 @default.
- W2894925291 cites W2069684322 @default.
- W2894925291 cites W2071412381 @default.
- W2894925291 cites W2071962829 @default.
- W2894925291 cites W2072194885 @default.
- W2894925291 cites W2073340956 @default.
- W2894925291 cites W2078003979 @default.
- W2894925291 cites W2085092579 @default.
- W2894925291 cites W2091702810 @default.
- W2894925291 cites W2092027270 @default.
- W2894925291 cites W2092912586 @default.
- W2894925291 cites W2093146349 @default.
- W2894925291 cites W2093519904 @default.
- W2894925291 cites W2101093878 @default.
- W2894925291 cites W2104788426 @default.
- W2894925291 cites W2105025183 @default.
- W2894925291 cites W2107731942 @default.
- W2894925291 cites W2108371668 @default.
- W2894925291 cites W2117131162 @default.
- W2894925291 cites W2118542750 @default.
- W2894925291 cites W2118862408 @default.
- W2894925291 cites W2118916005 @default.
- W2894925291 cites W2119996277 @default.
- W2894925291 cites W2120478300 @default.
- W2894925291 cites W2120628024 @default.
- W2894925291 cites W2121910267 @default.
- W2894925291 cites W2122595905 @default.
- W2894925291 cites W2125642777 @default.