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- W2894927292 endingPage "318" @default.
- W2894927292 startingPage "305" @default.
- W2894927292 abstract "Brain magnetic resonance elastography (MRE) was developed on the basis of a desire to palpate by imaging and is becoming a powerful tool in the investigation of neurophysiological and neuropathological states. Measurements are acquired with a specialized MR phase-contrast pulse sequence that can detect tissue motion in response to an applied external or internal excitation. The tissue viscoelasticity is then reconstructed from the measured displacement. Quantitative characterization of brain viscoelastic behaviors provides us an insight into the brain structure and function by assessing the mechanical rigidity, viscosity, friction, and connectivity of brain tissues. Changes in these features are associated with inflammation, demyelination, and neurodegeneration that contribute to brain disease onset and progression. Here, we review the basic principles and limitations of brain MRE and summarize its current neuroanatomical studies and clinical applications to the most common neurosurgical and neurodegenerative disorders, including intracranial tumors, dementia, multiple sclerosis, amyotrophic lateral sclerosis, and traumatic brain injury. Going forward, further improvement in acquisition techniques, stable inverse reconstruction algorithms, and advanced numerical, physical, and preclinical validation models is needed to increase the utility of brain MRE in both research and clinical applications." @default.
- W2894927292 created "2018-10-12" @default.
- W2894927292 creator A5006031903 @default.
- W2894927292 creator A5033590630 @default.
- W2894927292 creator A5038535858 @default.
- W2894927292 creator A5080515239 @default.
- W2894927292 creator A5085536490 @default.
- W2894927292 date "2018-10-01" @default.
- W2894927292 modified "2023-10-12" @default.
- W2894927292 title "Stiffness and Beyond" @default.
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