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• W2894930186 abstract "Summary There is a major unmet need for biomarkers of epilepsy. Biofluids such as blood offer a potential source of molecular biomarkers. Micro RNA s (miRNAs) fulfill several key requirements for a blood‐based molecular biomarker being enriched in the brain and dysregulated in epileptic brain tissue, and manipulation of mi RNA s can have seizure‐suppressive and disease‐modifying effects in preclinical models. Biofluid mi RNA s also possess qualities that are favorable for translation, including stability and easy and cheap assay techniques. Herein we review findings from both clinical and animal models. Studies have featured a mix of unbiased profiling and hypothesis‐driven efforts. Blood levels of several brain‐enriched mi RNA s are altered in patients with epilepsy and in patients with drug‐resistant compared to drug‐responsive seizures, with encouraging receiver‐operating characteristic ( ROC ) curve analyses, both in terms of sensitivity and specificity. Both focal and generalized epilepsies are associated with altered blood mi RNA profiles, and associations with clinical parameters including seizure burden have been reported. Results remain preliminary, however. There is a need for continued discovery and validation efforts that include multicenter studies and attention to study design, sample collection methodology, and quality control. Studies focused on epileptogenesis as well as associations with covariables such as sex, etiology, and timing of sampling remain limited. We identify 10 knowledge gaps and propose experiments to close these. If adequately addressed, biofluid mi RNA s may be an important future source of diagnostic biomarkers that could also support forthcoming trials of antiepileptogenesis or disease‐modifying therapies." @default.
• W2894930186 created "2018-10-12" @default.
• W2894930186 creator A5002978004 @default.
• W2894930186 creator A5039256755 @default.
• W2894930186 creator A5077920725 @default.
• W2894930186 date "2018-10-30" @default.
• W2894930186 modified "2023-10-14" @default.
• W2894930186 title "Discovery and validation of blood microRNAs as molecular biomarkers of epilepsy: Ways to close current knowledge gaps" @default.
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• W2894930186 doi "https://doi.org/10.1002/epi4.12275" @default.
• W2894930186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6276772" @default.
• W2894930186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30525113" @default.
• W2894930186 hasPublicationYear "2018" @default.
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