Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894937101> ?p ?o ?g. }
- W2894937101 endingPage "e017986" @default.
- W2894937101 startingPage "e017986" @default.
- W2894937101 abstract "Introduction Breast cancer affects 1 in 10 women worldwide, and mastectomy is a cause of chronic pain with neuropathic characteristics. N -methyl-D-aspartate receptor (NMDAR) antagonists such as ketamine, memantine, dextromethorphan or magnesium are used to treat refractory pain by blocking NMDAR. Oral memantine has been shown to prevent postmastectomy pain and cognitive impact and to maintain quality of life. Likewise, the present study is intended to assess the preventive effect of oral magnesium, administered ahead of mastectomy, on the development of neuropathic pain. As a physiological blocker of NMDAR, magnesium could be an interesting candidate to prevent postoperative pain and associated comorbidities, including cognitive and emotional disorders, multiple analgesic consumption and impaired quality of life. Methods and analysis A randomised double-blind controlled clinical trial ( NCT03063931 ) will include 100 women with breast cancer undergoing mastectomy at the Oncology Hospital, Clermont-Ferrand, France. Magnesium (100 mg/day; n=50) or placebo (n=50) will be administered for 6 weeks, starting 2 weeks before surgery. Intensity of pain, cognitive and emotional function and quality of life will be assessed by questionnaires. The primary endpoint is pain intensity on a 0–10 numerical rating scale at 1 month postmastectomy. Data analysis will use mixed models; all tests will be two-tailed, with type-I error set at α=0.05. Ethics and dissemination The study protocol and informed consent form were approved in December 2016 by the French Research Ethics Committee (South East VI Committee). Results will be communicated in various congresses and published in international publications. Trial registration number NCT03063931 ." @default.
- W2894937101 created "2018-10-12" @default.
- W2894937101 creator A5013394355 @default.
- W2894937101 creator A5028086934 @default.
- W2894937101 creator A5036480804 @default.
- W2894937101 creator A5077272373 @default.
- W2894937101 creator A5085504029 @default.
- W2894937101 date "2018-09-01" @default.
- W2894937101 modified "2023-09-24" @default.
- W2894937101 title "Preventive effect of oral magnesium in postmastectomy pain: protocol for a randomised, double-blind, controlled clinical trial" @default.
- W2894937101 cites W1509047972 @default.
- W2894937101 cites W1517655925 @default.
- W2894937101 cites W170257863 @default.
- W2894937101 cites W1919789995 @default.
- W2894937101 cites W1967480902 @default.
- W2894937101 cites W1968949726 @default.
- W2894937101 cites W1983182638 @default.
- W2894937101 cites W1988059170 @default.
- W2894937101 cites W1998100194 @default.
- W2894937101 cites W2000757372 @default.
- W2894937101 cites W2000808619 @default.
- W2894937101 cites W2004277545 @default.
- W2894937101 cites W2005376246 @default.
- W2894937101 cites W2006957372 @default.
- W2894937101 cites W2009830194 @default.
- W2894937101 cites W2011455771 @default.
- W2894937101 cites W2027762227 @default.
- W2894937101 cites W2031090590 @default.
- W2894937101 cites W2036394232 @default.
- W2894937101 cites W2039898366 @default.
- W2894937101 cites W2040277744 @default.
- W2894937101 cites W2040392095 @default.
- W2894937101 cites W2043780699 @default.
- W2894937101 cites W2044711292 @default.
- W2894937101 cites W2047571858 @default.
- W2894937101 cites W2049423536 @default.
- W2894937101 cites W2057837118 @default.
- W2894937101 cites W2060622064 @default.
- W2894937101 cites W2061623382 @default.
- W2894937101 cites W2064016561 @default.
- W2894937101 cites W2065940552 @default.
- W2894937101 cites W2077724220 @default.
- W2894937101 cites W2081463867 @default.
- W2894937101 cites W2085752402 @default.
- W2894937101 cites W2086214501 @default.
- W2894937101 cites W2087809724 @default.
- W2894937101 cites W2095349893 @default.
- W2894937101 cites W2096502479 @default.
- W2894937101 cites W2103185680 @default.
- W2894937101 cites W2106355595 @default.
- W2894937101 cites W2106836212 @default.
- W2894937101 cites W2120081212 @default.
- W2894937101 cites W2136042076 @default.
- W2894937101 cites W2139463678 @default.
- W2894937101 cites W2143960928 @default.
- W2894937101 cites W2146991933 @default.
- W2894937101 cites W2149042744 @default.
- W2894937101 cites W2151487996 @default.
- W2894937101 cites W2155301648 @default.
- W2894937101 cites W2155412494 @default.
- W2894937101 cites W2167571044 @default.
- W2894937101 cites W2168502604 @default.
- W2894937101 cites W2170956110 @default.
- W2894937101 cites W2172297511 @default.
- W2894937101 cites W2226035679 @default.
- W2894937101 cites W2326312889 @default.
- W2894937101 cites W2341444720 @default.
- W2894937101 cites W2481003159 @default.
- W2894937101 cites W3149120481 @default.
- W2894937101 cites W4242467572 @default.
- W2894937101 cites W4249436844 @default.
- W2894937101 cites W1791763263 @default.
- W2894937101 doi "https://doi.org/10.1136/bmjopen-2017-017986" @default.
- W2894937101 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6173239" @default.
- W2894937101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30287600" @default.
- W2894937101 hasPublicationYear "2018" @default.
- W2894937101 type Work @default.
- W2894937101 sameAs 2894937101 @default.
- W2894937101 citedByCount "8" @default.
- W2894937101 countsByYear W28949371012020 @default.
- W2894937101 countsByYear W28949371012021 @default.
- W2894937101 countsByYear W28949371012022 @default.
- W2894937101 crossrefType "journal-article" @default.
- W2894937101 hasAuthorship W2894937101A5013394355 @default.
- W2894937101 hasAuthorship W2894937101A5028086934 @default.
- W2894937101 hasAuthorship W2894937101A5036480804 @default.
- W2894937101 hasAuthorship W2894937101A5077272373 @default.
- W2894937101 hasAuthorship W2894937101A5085504029 @default.
- W2894937101 hasBestOaLocation W28949371011 @default.
- W2894937101 hasConcept C121608353 @default.
- W2894937101 hasConcept C126322002 @default.
- W2894937101 hasConcept C142724271 @default.
- W2894937101 hasConcept C159110408 @default.
- W2894937101 hasConcept C168563851 @default.
- W2894937101 hasConcept C1862650 @default.
- W2894937101 hasConcept C204787440 @default.
- W2894937101 hasConcept C27081682 @default.
- W2894937101 hasConcept C2777107010 @default.