FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894937507> ?p ?o ?g. }

• W2894937507 abstract "Abstract Among the many factors influencing fibrin formation and structure (concentration, temperature, composition, pH,…), it has been suggested that the polydispersity of fibrinogen may play an important role. We propose here a detailed investigation of the influence of this parameter on fibrin multiscale structure. Two commercial fibrinogen preparations were used, a monodisperse and a polydisperse one. First, the respective compositions of both fibrinogen preparations were thoroughly determined by measuring the FXIII, fibronectin, α,β and γ intact-chains contents, theγ/γ’ chains ratio, the N-glycosylation and the post-translational modifications. Slight variations between the composition of the two fibrinogen preparations were found which are much smaller than the compositional variations necessary to alter significantly fibrin multiscale structure as observed in the literature. Conversely, MALLS coupled SEC and DLS measurements showed that the polydisperse preparation contains significant amounts of aggregates while the other preparation is essentially monodisperse. The multiscale structure of the fibrins produced from those two fibrinogen preparations was determined by using X-ray scattering, spectrophotometry, and confocal microscopy. Results show that fibers from the monodisperse fibrinogen present a crystalline longitudinal and lateral structure and form a needle-like network. The internal structure of fibers produced from the polydisperse fibrinogen looks amorphous with star-like branching nodes. The multiscale structure of mixtures between the two preparations shows a smooth evolution, demonstrating that the quantity of aggregates is a major determining factor for fibrin multiscale structure. Indeed, the effect of a few percent in mass of aggregates is larger than any other effect due to compositional differences under the same reaction conditions. Finally we propose a mechanistic interpretation of our results which points at a direct role of the aggregates during polymerization which disrupt the ideal ordering of monomers inside fibrin protofibrils and fibers." @default.
• W2894937507 created "2018-10-12" @default.
• W2894937507 creator A5018688657 @default.
• W2894937507 creator A5027740665 @default.
• W2894937507 creator A5037967215 @default.
• W2894937507 creator A5049190885 @default.
• W2894937507 creator A5049793938 @default.
• W2894937507 creator A5066908758 @default.
• W2894937507 creator A5084959505 @default.
• W2894937507 date "2018-10-02" @default.
• W2894937507 modified "2023-10-18" @default.
• W2894937507 title "Aggregates dramatically alter fibrin ultrastructure" @default.
• W2894937507 cites W1966128576 @default.
• W2894937507 cites W1972282939 @default.
• W2894937507 cites W1989731897 @default.
• W2894937507 cites W1990922681 @default.
• W2894937507 cites W1998529033 @default.
• W2894937507 cites W2011339820 @default.
• W2894937507 cites W2017851692 @default.
• W2894937507 cites W2042435132 @default.
• W2894937507 cites W2043471126 @default.
• W2894937507 cites W2047682340 @default.
• W2894937507 cites W2068324201 @default.
• W2894937507 cites W2089877304 @default.
• W2894937507 cites W2123310999 @default.
• W2894937507 cites W2141827979 @default.
• W2894937507 cites W2145928494 @default.
• W2894937507 cites W2148831568 @default.
• W2894937507 cites W2154036638 @default.
• W2894937507 cites W2159729866 @default.
• W2894937507 cites W2290533436 @default.
• W2894937507 cites W2319153765 @default.
• W2894937507 cites W2327264262 @default.
• W2894937507 cites W2337841764 @default.
• W2894937507 cites W2617620306 @default.
• W2894937507 cites W2761516690 @default.
• W2894937507 cites W2054572091 @default.
• W2894937507 doi "https://doi.org/10.1101/432138" @default.
• W2894937507 hasPublicationYear "2018" @default.
• W2894937507 type Work @default.
• W2894937507 sameAs 2894937507 @default.
• W2894937507 citedByCount "2" @default.
• W2894937507 countsByYear W28949375072020 @default.
• W2894937507 crossrefType "posted-content" @default.
• W2894937507 hasAuthorship W2894937507A5018688657 @default.
• W2894937507 hasAuthorship W2894937507A5027740665 @default.
• W2894937507 hasAuthorship W2894937507A5037967215 @default.
• W2894937507 hasAuthorship W2894937507A5049190885 @default.
• W2894937507 hasAuthorship W2894937507A5049793938 @default.
• W2894937507 hasAuthorship W2894937507A5066908758 @default.
• W2894937507 hasAuthorship W2894937507A5084959505 @default.
• W2894937507 hasBestOaLocation W28949375071 @default.
• W2894937507 hasConcept C105702510 @default.
• W2894937507 hasConcept C11432220 @default.
• W2894937507 hasConcept C120665830 @default.
• W2894937507 hasConcept C121332964 @default.
• W2894937507 hasConcept C12554922 @default.
• W2894937507 hasConcept C127413603 @default.
• W2894937507 hasConcept C178790620 @default.
• W2894937507 hasConcept C185592680 @default.
• W2894937507 hasConcept C188027245 @default.
• W2894937507 hasConcept C192562407 @default.
• W2894937507 hasConcept C203014093 @default.
• W2894937507 hasConcept C206175624 @default.
• W2894937507 hasConcept C2779036427 @default.
• W2894937507 hasConcept C2779178360 @default.
• W2894937507 hasConcept C42360764 @default.
• W2894937507 hasConcept C43617362 @default.
• W2894937507 hasConcept C54173615 @default.
• W2894937507 hasConcept C55493867 @default.
• W2894937507 hasConcept C86803240 @default.
• W2894937507 hasConcept C87555872 @default.
• W2894937507 hasConceptScore W2894937507C105702510 @default.
• W2894937507 hasConceptScore W2894937507C11432220 @default.
• W2894937507 hasConceptScore W2894937507C120665830 @default.
• W2894937507 hasConceptScore W2894937507C121332964 @default.
• W2894937507 hasConceptScore W2894937507C12554922 @default.
• W2894937507 hasConceptScore W2894937507C127413603 @default.
• W2894937507 hasConceptScore W2894937507C178790620 @default.
• W2894937507 hasConceptScore W2894937507C185592680 @default.
• W2894937507 hasConceptScore W2894937507C188027245 @default.
• W2894937507 hasConceptScore W2894937507C192562407 @default.
• W2894937507 hasConceptScore W2894937507C203014093 @default.
• W2894937507 hasConceptScore W2894937507C206175624 @default.
• W2894937507 hasConceptScore W2894937507C2779036427 @default.
• W2894937507 hasConceptScore W2894937507C2779178360 @default.
• W2894937507 hasConceptScore W2894937507C42360764 @default.
• W2894937507 hasConceptScore W2894937507C43617362 @default.
• W2894937507 hasConceptScore W2894937507C54173615 @default.
• W2894937507 hasConceptScore W2894937507C55493867 @default.
• W2894937507 hasConceptScore W2894937507C86803240 @default.
• W2894937507 hasConceptScore W2894937507C87555872 @default.
• W2894937507 hasLocation W28949375071 @default.
• W2894937507 hasLocation W28949375072 @default.
• W2894937507 hasLocation W28949375073 @default.
• W2894937507 hasLocation W28949375074 @default.
• W2894937507 hasLocation W28949375075 @default.
• W2894937507 hasLocation W28949375076 @default.
• W2894937507 hasLocation W28949375077 @default.
• W2894937507 hasOpenAccess W2894937507 @default.

• next