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• W2894939756 abstract "Abstract Objective Subjects with low vitamin D levels are at risk of cardiometabolic disease. The aim of this study was to identify novel serological markers linking vitamin D status with cardiometabolic profile in non-diabetic adults with obesity. Methods For the discovery phase, we used quantitative serum proteomics in sex-matched, age-matched and BMI-matched subjects with obesity [BMI: 25–35 kg/m 2 ] and low [25(OH)D < 50 nmol/L] vs. high vitamin D status [25(OH)D > 50 nmol/L] ( n = 16). For the validation phase, we performed ELISA in a larger cohort with similar characteristics ( n = 179). Results We identified 423 and 549 differentially expressed proteins in the high vs. low vitamin D groups of the male and female cohorts, respectively. The small molecule biochemistry protein networks and the glycolysis|gluconeogenesis pathway were significantly enriched in the DEPs of both sexes. As surrogate markers to these processes, the insulin-like growth factor binding protein -2 (IGFBP-2) was upregulated in males, whereas IGFBP-3 was upregulated in females from the high Vitamin D status. This sex-specific trend was confirmed using Luminex ELISA to an independent but clinically analogous cohort of males ( n = 84, p = 0.002) and females ( n = 95, p = 0.03). Conclusions The high Vitamin D status correlated with the serological upregulation of IGFBP-2 in males and IGFBP-3 in females with obesity and may constitute surrogate markers of risk reduction of cardiometabolic disease." @default.
• W2894939756 created "2018-10-12" @default.
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• W2894939756 date "2018-10-04" @default.
• W2894939756 modified "2023-10-10" @default.
• W2894939756 title "Sex-specific correlation of IGFBP-2 and IGFBP-3 with vitamin D status in adults with obesity: a cross-sectional serum proteomics study" @default.
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• W2894939756 doi "https://doi.org/10.1038/s41387-018-0063-8" @default.
• W2894939756 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6172285" @default.
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