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- W2894943452 abstract "Introduction: The giant myofilament protein titin is a critical determinant of myofibril elasticity and sarcomere structure in striated muscle. Although significant advances have been made in our understanding of the biophysical and mechanical properties of titin, the mechanisms governing sarcomeric titin turnover are poorly understood. Our goal is to establish a cardiomyocyte cell culture model that would enable visualization of sarcomeric titin turnover, in real-time. Methods and Results: To directly visualize titin incorporation and turnover in cardiac sarcomeres, we used CRISPR/Cas9 genome editing in human induced pluripotent stem cells (hiPSC) to knock-in a photoconvertible fluorescent protein, mEos3.2, into the C-terminus of titin to produce hiPSC-derived cardiomyocytes (hiPSC-CM) that express endogenous sarcomeric titin-mEos3.2 fusion proteins. Cardiomyocyte induction of the titin-mEos3.2 hiPSC line demonstrated that the titin-mEos3.2 fusion protein is expressed in the sarcomeres in the expected st..." @default.
- W2894943452 created "2018-10-12" @default.
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- W2894943452 date "2016-11-11" @default.
- W2894943452 modified "2023-10-02" @default.
- W2894943452 title "Abstract 19317: Real-Time Visualization of Endogenous Titin Dynamics in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes" @default.
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