FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894945456> ?p ?o ?g. }

• W2894945456 endingPage "30" @default.
• W2894945456 startingPage "23" @default.
• W2894945456 abstract "Whole tumor cell lysates consist of a mixture of tumor antigens and danger associated molecular patterns (DAMPs) that can be used for dendritic cell maturation and consequently for the activation of a polyclonal T cell-specific tumor response. We evaluated the in vitro efficacy of three different preparations of canine transmissible venereal tumor (TVT) cell lysates: hypochlorous acid-whole tumor cell lysates (HOCl-L), heat shock-whole tumor cell lysates (HS-L), and freeze-thaw cycles-whole tumor cell lysates (FT-L) for the maturation of canine-derived dendritic cells. Our results showed calreticulin, HSP70, and HSP90 release in the three tumor lysates preparations (HOCl-L, HS-L, and FT-L); however, HMGB1 was detected only in HOCl-L and FT-L. Additionally, the uptake by HOCl-L pulsed dendritic cell (DC) increased compared to HS-L and FT-L pulsed DC; and dendritic cell maturation was confirmed by the appropriate cell surface markers (CD11c, CD80, CD83, and MHCII). Furthermore, dendritic cells pulsed with HOCl-L, HS-L or FT-L were cultured with canine lymphocytes. There was an increase of Th1-type cytokines (IL-12, TNF-α, and IFN-γ), in all the tumor cell lysates co-cultures, this correlates with T lymphocyte activation and cytotoxic response. Our data confirm that TVT cell lysates can induce functional canine-DC and that HOCl-L is the most effective one. This preparation of TVT cell lysates with HOCl is an attractive approach that allows the recognition of neoantigens as potential tumor targets and DC priming and therefore could be used for cancer immunotherapy against TVT." @default.
• W2894945456 created "2018-10-12" @default.
• W2894945456 creator A5015471385 @default.
• W2894945456 creator A5024954569 @default.
• W2894945456 creator A5034899428 @default.
• W2894945456 creator A5036853860 @default.
• W2894945456 creator A5054335791 @default.
• W2894945456 creator A5067265318 @default.
• W2894945456 creator A5085687098 @default.
• W2894945456 creator A5090364483 @default.
• W2894945456 date "2018-12-01" @default.
• W2894945456 modified "2023-10-18" @default.
• W2894945456 title "Immunogenic potential of three transmissible venereal tumor cell lysates to prime canine-dendritic cells for cancer immunotherapy" @default.
• W2894945456 cites W1965628169 @default.
• W2894945456 cites W2007040683 @default.
• W2894945456 cites W2023567649 @default.
• W2894945456 cites W2049801980 @default.
• W2894945456 cites W2067773598 @default.
• W2894945456 cites W2089187782 @default.
• W2894945456 cites W2090789725 @default.
• W2894945456 cites W2103644250 @default.
• W2894945456 cites W2110775359 @default.
• W2894945456 cites W2129873891 @default.
• W2894945456 cites W2135432827 @default.
• W2894945456 cites W2148613067 @default.
• W2894945456 cites W2156057520 @default.
• W2894945456 cites W2163838780 @default.
• W2894945456 cites W2619421189 @default.
• W2894945456 cites W2727905197 @default.
• W2894945456 cites W2770884891 @default.
• W2894945456 cites W2945658169 @default.
• W2894945456 doi "https://doi.org/10.1016/j.rvsc.2018.10.001" @default.
• W2894945456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30316013" @default.
• W2894945456 hasPublicationYear "2018" @default.
• W2894945456 type Work @default.
• W2894945456 sameAs 2894945456 @default.
• W2894945456 citedByCount "6" @default.
• W2894945456 countsByYear W28949454562019 @default.
• W2894945456 countsByYear W28949454562021 @default.
• W2894945456 countsByYear W28949454562022 @default.
• W2894945456 countsByYear W28949454562023 @default.
• W2894945456 crossrefType "journal-article" @default.
• W2894945456 hasAuthorship W2894945456A5015471385 @default.
• W2894945456 hasAuthorship W2894945456A5024954569 @default.
• W2894945456 hasAuthorship W2894945456A5034899428 @default.
• W2894945456 hasAuthorship W2894945456A5036853860 @default.
• W2894945456 hasAuthorship W2894945456A5054335791 @default.
• W2894945456 hasAuthorship W2894945456A5067265318 @default.
• W2894945456 hasAuthorship W2894945456A5085687098 @default.
• W2894945456 hasAuthorship W2894945456A5090364483 @default.
• W2894945456 hasConcept C100701293 @default.
• W2894945456 hasConcept C147483822 @default.
• W2894945456 hasConcept C1491633281 @default.
• W2894945456 hasConcept C153911025 @default.
• W2894945456 hasConcept C154317977 @default.
• W2894945456 hasConcept C185592680 @default.
• W2894945456 hasConcept C202751555 @default.
• W2894945456 hasConcept C203014093 @default.
• W2894945456 hasConcept C2776090121 @default.
• W2894945456 hasConcept C2776662205 @default.
• W2894945456 hasConcept C2778170410 @default.
• W2894945456 hasConcept C2778297628 @default.
• W2894945456 hasConcept C39347974 @default.
• W2894945456 hasConcept C502942594 @default.
• W2894945456 hasConcept C55493867 @default.
• W2894945456 hasConcept C59822182 @default.
• W2894945456 hasConcept C81444415 @default.
• W2894945456 hasConcept C86803240 @default.
• W2894945456 hasConcept C8891405 @default.
• W2894945456 hasConceptScore W2894945456C100701293 @default.
• W2894945456 hasConceptScore W2894945456C147483822 @default.
• W2894945456 hasConceptScore W2894945456C1491633281 @default.
• W2894945456 hasConceptScore W2894945456C153911025 @default.
• W2894945456 hasConceptScore W2894945456C154317977 @default.
• W2894945456 hasConceptScore W2894945456C185592680 @default.
• W2894945456 hasConceptScore W2894945456C202751555 @default.
• W2894945456 hasConceptScore W2894945456C203014093 @default.
• W2894945456 hasConceptScore W2894945456C2776090121 @default.
• W2894945456 hasConceptScore W2894945456C2776662205 @default.
• W2894945456 hasConceptScore W2894945456C2778170410 @default.
• W2894945456 hasConceptScore W2894945456C2778297628 @default.
• W2894945456 hasConceptScore W2894945456C39347974 @default.
• W2894945456 hasConceptScore W2894945456C502942594 @default.
• W2894945456 hasConceptScore W2894945456C55493867 @default.
• W2894945456 hasConceptScore W2894945456C59822182 @default.
• W2894945456 hasConceptScore W2894945456C81444415 @default.
• W2894945456 hasConceptScore W2894945456C86803240 @default.
• W2894945456 hasConceptScore W2894945456C8891405 @default.
• W2894945456 hasFunder F4320322803 @default.
• W2894945456 hasLocation W28949454561 @default.
• W2894945456 hasLocation W28949454562 @default.
• W2894945456 hasOpenAccess W2894945456 @default.
• W2894945456 hasPrimaryLocation W28949454561 @default.
• W2894945456 hasRelatedWork W1483285805 @default.
• W2894945456 hasRelatedWork W1587463748 @default.
• W2894945456 hasRelatedWork W1914975684 @default.
• W2894945456 hasRelatedWork W1969011226 @default.
• W2894945456 hasRelatedWork W1996814634 @default.

• next