FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894945499> ?p ?o ?g. }

• W2894945499 endingPage "2618" @default.
• W2894945499 startingPage "2608" @default.
• W2894945499 abstract "The Solanum tuberosum plant-specific insert (StPSI) has been shown to possess potent antimicrobial activity against both human and plant pathogens. Furthermore, in vitro, the StPSI is capable of fusing phospholipid vesicles, provided the conditions of net anionic vesicle charge and acidic pH are met. Constant pH replica-exchange simulations indicate several acidic residues on the dimer have highly perturbed pKas (<3.0; E15, D28, E85 & E100) due to involvement in salt bridges. After setting the pH of the system to either 3.0 or 7.4, all-atom simulations provided details of the effect of pH on secondary structural elements, particularly in the previously unresolved crystallographic structure of the loop section. Coarse-grained dimer-bilayer simulations demonstrated that at pH 7.4, the dimer had no affinity for neutral or anionic membranes over the course of 1 μs simulations. Conversely, at pH 3.0 two binding modes were observed. Mode 1 is mediated primarily via strong N-terminal interactions on one monomer only, whereas in mode 2, N- and C-terminal residues of one monomer and numerous polar and basic residues on the second monomer, particularly in the third helix, participate in membrane interactions. Mode 2 was accompanied by re-orientation of the dimer to a more vertical position with respect to helices 1 and 4, positioning the dimer for membrane interactions. These results offer the first examination at near-atomic resolution of residues mediating the StPSI-membrane interactions, and allow for the postulation of a possible fusion mechanism." @default.
• W2894945499 created "2018-10-12" @default.
• W2894945499 creator A5006040392 @default.
• W2894945499 creator A5017392485 @default.
• W2894945499 creator A5028734301 @default.
• W2894945499 creator A5033002485 @default.
• W2894945499 creator A5034475461 @default.
• W2894945499 creator A5062918954 @default.
• W2894945499 creator A5064609573 @default.
• W2894945499 creator A5077883603 @default.
• W2894945499 date "2018-12-01" @default.
• W2894945499 modified "2023-09-27" @default.
• W2894945499 title "pH dependent membrane binding of the Solanum tuberosum plant specific insert: An in silico study" @default.
• W2894945499 cites W1109763329 @default.
• W2894945499 cites W1495702220 @default.
• W2894945499 cites W1883224873 @default.
• W2894945499 cites W1968471406 @default.
• W2894945499 cites W1974571658 @default.
• W2894945499 cites W1977203758 @default.
• W2894945499 cites W1985842673 @default.
• W2894945499 cites W1986199521 @default.
• W2894945499 cites W1986785104 @default.
• W2894945499 cites W1992636402 @default.
• W2894945499 cites W1994247230 @default.
• W2894945499 cites W1999853277 @default.
• W2894945499 cites W2005423400 @default.
• W2894945499 cites W2008708467 @default.
• W2894945499 cites W2008983333 @default.
• W2894945499 cites W2018547218 @default.
• W2894945499 cites W2024531674 @default.
• W2894945499 cites W2027408247 @default.
• W2894945499 cites W2029667189 @default.
• W2894945499 cites W2032187756 @default.
• W2894945499 cites W2035266068 @default.
• W2894945499 cites W2035687084 @default.
• W2894945499 cites W2040747445 @default.
• W2894945499 cites W2043553429 @default.
• W2894945499 cites W2046102151 @default.
• W2894945499 cites W2051864856 @default.
• W2894945499 cites W2056760934 @default.
• W2894945499 cites W2057477511 @default.
• W2894945499 cites W2064414576 @default.
• W2894945499 cites W2065283382 @default.
• W2894945499 cites W2067100150 @default.
• W2894945499 cites W2070144513 @default.
• W2894945499 cites W2070280888 @default.
• W2894945499 cites W2078429267 @default.
• W2894945499 cites W2081693079 @default.
• W2894945499 cites W2086207983 @default.
• W2894945499 cites W2089495268 @default.
• W2894945499 cites W2091095874 @default.
• W2894945499 cites W2091414864 @default.
• W2894945499 cites W2091438515 @default.
• W2894945499 cites W2091589417 @default.
• W2894945499 cites W2091664813 @default.
• W2894945499 cites W2099133435 @default.
• W2894945499 cites W2103517636 @default.
• W2894945499 cites W2107317356 @default.
• W2894945499 cites W2111994795 @default.
• W2894945499 cites W2119267663 @default.
• W2894945499 cites W2121339927 @default.
• W2894945499 cites W2128572087 @default.
• W2894945499 cites W2132262459 @default.
• W2894945499 cites W2137697984 @default.
• W2894945499 cites W2142532813 @default.
• W2894945499 cites W2161605421 @default.
• W2894945499 cites W2163168043 @default.
• W2894945499 cites W2165085316 @default.
• W2894945499 cites W2168240189 @default.
• W2894945499 cites W2170711116 @default.
• W2894945499 cites W2171268876 @default.
• W2894945499 cites W2171316918 @default.
• W2894945499 cites W2171476409 @default.
• W2894945499 cites W2266854443 @default.
• W2894945499 cites W2294803096 @default.
• W2894945499 cites W2323178299 @default.
• W2894945499 cites W2327174080 @default.
• W2894945499 cites W2569976629 @default.
• W2894945499 cites W2588773973 @default.
• W2894945499 cites W2062807077 @default.
• W2894945499 doi "https://doi.org/10.1016/j.bbamem.2018.10.001" @default.
• W2894945499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30291921" @default.
• W2894945499 hasPublicationYear "2018" @default.
• W2894945499 type Work @default.
• W2894945499 sameAs 2894945499 @default.
• W2894945499 citedByCount "4" @default.
• W2894945499 countsByYear W28949454992020 @default.
• W2894945499 countsByYear W28949454992022 @default.
• W2894945499 crossrefType "journal-article" @default.
• W2894945499 hasAuthorship W2894945499A5006040392 @default.
• W2894945499 hasAuthorship W2894945499A5017392485 @default.
• W2894945499 hasAuthorship W2894945499A5028734301 @default.
• W2894945499 hasAuthorship W2894945499A5033002485 @default.
• W2894945499 hasAuthorship W2894945499A5034475461 @default.
• W2894945499 hasAuthorship W2894945499A5062918954 @default.
• W2894945499 hasAuthorship W2894945499A5064609573 @default.
• W2894945499 hasAuthorship W2894945499A5077883603 @default.
• W2894945499 hasConcept C12554922 @default.

• next