FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894947328> ?p ?o ?g. }

• W2894947328 endingPage "255" @default.
• W2894947328 startingPage "251" @default.
• W2894947328 abstract "Chromosome 12q15 was identified in Genetic Epidemiology of Response Assessment (GERA) and replicated in Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) for its association with blood pressure (BP) response to hydrochlorothiazide (HCTZ). However, the functional variant is unknown and we aimed to identify the likely functional variants through targeted sequencing. The chromosome 12q15 region was sequenced in 397 best and worst responders to HCTZ in PEAR (N=199) and GERA (N=198) hypertensive study participants. Logistic regression was used for the association analysis adjusting for age, sex, race, and principal components 1 and 2. For validation, the significant single nucleotide polymorphism was tested for association with the change in systolic (ΔSBP) and diastolic BP (ΔDBP) post-treatment in the entire PEAR (N=370) and GERA (N=570) cohorts. A novel missense polymorphism (G>A, Pro383Leu) in BEST3, rs61747221, was significantly associated with better HCTZ response (P=0.0021, odds ratio=2.05). It was validated in the entire cohort of PEAR (ΔSBP: P=0.021, β=-1.60, ΔDBP: P=0.023, β=-1.08) and GERA (ΔSBP: P=0.028, β=-1.95, ΔDBP: P=0.032, β=-1.28). BEST3 encodes the calcium sensitive chloride channel in the vascular smooth muscle implicated in the regulation of BP, especially in response to vasoconstrictors like angiotensin II. These results suggest that BEST3 is involved in the chronic BP lowering mechanism of thiazides and highlight its importance as a genetic predictor of the BP response to thiazide diuretics." @default.
• W2894947328 created "2018-10-12" @default.
• W2894947328 creator A5011537086 @default.
• W2894947328 creator A5015240028 @default.
• W2894947328 creator A5020272363 @default.
• W2894947328 creator A5037957960 @default.
• W2894947328 creator A5044048476 @default.
• W2894947328 creator A5047295889 @default.
• W2894947328 creator A5048091406 @default.
• W2894947328 creator A5061196407 @default.
• W2894947328 creator A5061865147 @default.
• W2894947328 creator A5071151925 @default.
• W2894947328 creator A5072564819 @default.
• W2894947328 creator A5075968422 @default.
• W2894947328 creator A5081119135 @default.
• W2894947328 creator A5086802746 @default.
• W2894947328 creator A5088669682 @default.
• W2894947328 date "2018-11-01" @default.
• W2894947328 modified "2023-09-25" @default.
• W2894947328 title "Targeted sequencing identifies a missense variant in the BEST3 gene associated with antihypertensive response to hydrochlorothiazide" @default.
• W2894947328 cites W1534596534 @default.
• W2894947328 cites W182429776 @default.
• W2894947328 cites W1986264879 @default.
• W2894947328 cites W1988449174 @default.
• W2894947328 cites W2000799095 @default.
• W2894947328 cites W2018838463 @default.
• W2894947328 cites W2020328088 @default.
• W2894947328 cites W2023629436 @default.
• W2894947328 cites W2033375786 @default.
• W2894947328 cites W2052606608 @default.
• W2894947328 cites W2054818418 @default.
• W2894947328 cites W2058159909 @default.
• W2894947328 cites W2061043894 @default.
• W2894947328 cites W2062753460 @default.
• W2894947328 cites W2086935846 @default.
• W2894947328 cites W2099085143 @default.
• W2894947328 cites W2101719140 @default.
• W2894947328 cites W2103302777 @default.
• W2894947328 cites W2103441770 @default.
• W2894947328 cites W2105318826 @default.
• W2894947328 cites W2108656183 @default.
• W2894947328 cites W2127755983 @default.
• W2894947328 cites W2131008034 @default.
• W2894947328 cites W2138838688 @default.
• W2894947328 cites W2161633633 @default.
• W2894947328 cites W2161989611 @default.
• W2894947328 cites W2266731778 @default.
• W2894947328 cites W2546010425 @default.
• W2894947328 cites W2549139405 @default.
• W2894947328 doi "https://doi.org/10.1097/fpc.0000000000000353" @default.
• W2894947328 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6262886" @default.
• W2894947328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30289819" @default.
• W2894947328 hasPublicationYear "2018" @default.
• W2894947328 type Work @default.
• W2894947328 sameAs 2894947328 @default.
• W2894947328 citedByCount "6" @default.
• W2894947328 countsByYear W28949473282019 @default.
• W2894947328 countsByYear W28949473282020 @default.
• W2894947328 countsByYear W28949473282022 @default.
• W2894947328 crossrefType "journal-article" @default.
• W2894947328 hasAuthorship W2894947328A5011537086 @default.
• W2894947328 hasAuthorship W2894947328A5015240028 @default.
• W2894947328 hasAuthorship W2894947328A5020272363 @default.
• W2894947328 hasAuthorship W2894947328A5037957960 @default.
• W2894947328 hasAuthorship W2894947328A5044048476 @default.
• W2894947328 hasAuthorship W2894947328A5047295889 @default.
• W2894947328 hasAuthorship W2894947328A5048091406 @default.
• W2894947328 hasAuthorship W2894947328A5061196407 @default.
• W2894947328 hasAuthorship W2894947328A5061865147 @default.
• W2894947328 hasAuthorship W2894947328A5071151925 @default.
• W2894947328 hasAuthorship W2894947328A5072564819 @default.
• W2894947328 hasAuthorship W2894947328A5075968422 @default.
• W2894947328 hasAuthorship W2894947328A5081119135 @default.
• W2894947328 hasAuthorship W2894947328A5086802746 @default.
• W2894947328 hasAuthorship W2894947328A5088669682 @default.
• W2894947328 hasBestOaLocation W28949473282 @default.
• W2894947328 hasConcept C104317684 @default.
• W2894947328 hasConcept C126322002 @default.
• W2894947328 hasConcept C134018914 @default.
• W2894947328 hasConcept C135763542 @default.
• W2894947328 hasConcept C143998085 @default.
• W2894947328 hasConcept C153209595 @default.
• W2894947328 hasConcept C156957248 @default.
• W2894947328 hasConcept C2780361556 @default.
• W2894947328 hasConcept C2780437262 @default.
• W2894947328 hasConcept C501734568 @default.
• W2894947328 hasConcept C54355233 @default.
• W2894947328 hasConcept C60644358 @default.
• W2894947328 hasConcept C71924100 @default.
• W2894947328 hasConcept C75563809 @default.
• W2894947328 hasConcept C84393581 @default.
• W2894947328 hasConcept C86803240 @default.
• W2894947328 hasConcept C98274493 @default.
• W2894947328 hasConceptScore W2894947328C104317684 @default.
• W2894947328 hasConceptScore W2894947328C126322002 @default.
• W2894947328 hasConceptScore W2894947328C134018914 @default.
• W2894947328 hasConceptScore W2894947328C135763542 @default.
• W2894947328 hasConceptScore W2894947328C143998085 @default.

• next