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• W2894948181 endingPage "3958" @default.
• W2894948181 startingPage "3941" @default.
• W2894948181 abstract "Snake venoms are complex mixtures mainly composed of proteins and small peptides. Crotoxin is one of the most studied components from Crotalus venoms, but many other components are less known due to their low abundance. The venome of Crotalus durissus terrificus, the most lethal Brazilian snake, was investigated by combining its venom gland transcriptome and proteome to create a holistic database of venom compounds unraveling novel toxins. We constructed a cDNA library from C. d. terrificus venom gland using the Illumina platform and investigated its venom proteome through high resolution liquid chromotography-tandem mass spectrometry. After integrating data from both data sets, more than 30 venom components classes were identified by the transcriptomic analysis and 15 of them were detected in the venom proteome. However, few of them (PLA2, SVMP, SVSP, and VEGF) were relatively abundant. Furthermore, only seven expressed transcripts contributed to ∼82% and ∼73% of the abundance in the transcriptome and proteome, respectively. Additionally, novel venom proteins are reported, and we highlight the importance of using different databases to perform the data integration and discuss the structure of the venom components-related transcripts identified. Concluding, this research paves the way for novel investigations and discovery of future pharmacological agents or targets in the antivenom therapy." @default.
• W2894948181 created "2018-10-12" @default.
• W2894948181 creator A5007816551 @default.
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• W2894948181 creator A5065834363 @default.
• W2894948181 creator A5067341235 @default.
• W2894948181 creator A5078788774 @default.
• W2894948181 creator A5086921808 @default.
• W2894948181 date "2018-10-01" @default.
• W2894948181 modified "2023-10-15" @default.
• W2894948181 title "In-Depth Venome of the Brazilian Rattlesnake <i>Crotalus durissus terrificus</i>: An Integrative Approach Combining Its Venom Gland Transcriptome and Venom Proteome" @default.
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