FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894949219> ?p ?o ?g. }

• W2894949219 abstract "Despite substantial progress made towards a better understanding of the importance of skeletal muscle K+ regulation for human physical function and its association with several disease states (eg type-II diabetes and hypertension), the molecular basis underpinning adaptations in K+ regulation to various stimuli, including exercise training, remains inadequately explored in humans. In this review, the molecular mechanisms essential for enhancing skeletal muscle K+ regulation and its key determinants, including Na+,K+-ATPase function and expression, by exercise training are examined. Special attention is paid to the following molecular stressors and signaling proteins: oxygenation, redox balance, hypoxia, reactive oxygen species, antioxidant function, Na+,K+, and Ca2+ concentrations, anaerobic ATP turnover, AMPK, lactate, and mRNA expression. On this basis, an update on the effects of different types of exercise training on K+ regulation in humans is provided, focusing on recent discoveries about the muscle fibre-type-dependent regulation of Na+,K+-ATPase-isoform expression. Furthermore, with special emphasis on blood-flow-restricted exercise as an exemplary model to modulate the key molecular mechanisms identified, it is discussed how training interventions may be designed to maximize improvements in K+ regulation in humans. The novel insights gained from this review may help us to better understand how exercise training and other strategies, such as pharmacological interventions, may be best designed to enhance K+ regulation and thus the physical function in humans." @default.
• W2894949219 created "2018-10-12" @default.
• W2894949219 creator A5085531475 @default.
• W2894949219 date "2018-11-04" @default.
• W2894949219 modified "2023-10-14" @default.
• W2894949219 title "Molecular stressors underlying exercise training‐induced improvements in K⁺regulation during exercise and Na⁺,K⁺‐ATPase adaptation in human skeletal muscle" @default.
• W2894949219 cites W127100574 @default.
• W2894949219 cites W1482761079 @default.
• W2894949219 cites W1514745038 @default.
• W2894949219 cites W1515589939 @default.
• W2894949219 cites W1519766384 @default.
• W2894949219 cites W1522768491 @default.
• W2894949219 cites W1565331641 @default.
• W2894949219 cites W1570266557 @default.
• W2894949219 cites W1572468114 @default.
• W2894949219 cites W1574594312 @default.
• W2894949219 cites W1576137866 @default.
• W2894949219 cites W1581458957 @default.
• W2894949219 cites W1593117168 @default.
• W2894949219 cites W1596136273 @default.
• W2894949219 cites W1763398668 @default.
• W2894949219 cites W1813408719 @default.
• W2894949219 cites W1838748969 @default.
• W2894949219 cites W1870874128 @default.
• W2894949219 cites W1935697666 @default.
• W2894949219 cites W1945029457 @default.
• W2894949219 cites W1964578278 @default.
• W2894949219 cites W1964911738 @default.
• W2894949219 cites W1969197079 @default.
• W2894949219 cites W1969649414 @default.
• W2894949219 cites W1970611194 @default.
• W2894949219 cites W1971086835 @default.
• W2894949219 cites W1973296738 @default.
• W2894949219 cites W1973815254 @default.
• W2894949219 cites W1974752630 @default.
• W2894949219 cites W1978623167 @default.
• W2894949219 cites W1980469349 @default.
• W2894949219 cites W1980566344 @default.
• W2894949219 cites W1985384589 @default.
• W2894949219 cites W1985681603 @default.
• W2894949219 cites W1986838242 @default.
• W2894949219 cites W1988427947 @default.
• W2894949219 cites W1988901712 @default.
• W2894949219 cites W1989130029 @default.
• W2894949219 cites W1989524903 @default.
• W2894949219 cites W1989910165 @default.
• W2894949219 cites W1990662303 @default.
• W2894949219 cites W1993456943 @default.
• W2894949219 cites W1994429077 @default.
• W2894949219 cites W1997448590 @default.
• W2894949219 cites W1998567367 @default.
• W2894949219 cites W1999300597 @default.
• W2894949219 cites W1999795510 @default.
• W2894949219 cites W2000189769 @default.
• W2894949219 cites W2001380129 @default.
• W2894949219 cites W2002114838 @default.
• W2894949219 cites W2003776499 @default.
• W2894949219 cites W2004829381 @default.
• W2894949219 cites W2005451680 @default.
• W2894949219 cites W2006506883 @default.
• W2894949219 cites W2009165096 @default.
• W2894949219 cites W2010284467 @default.
• W2894949219 cites W2012907081 @default.
• W2894949219 cites W2014380310 @default.
• W2894949219 cites W2016478729 @default.
• W2894949219 cites W2021524303 @default.
• W2894949219 cites W2021628662 @default.
• W2894949219 cites W2025919972 @default.
• W2894949219 cites W2028211887 @default.
• W2894949219 cites W2028695144 @default.
• W2894949219 cites W2029344628 @default.
• W2894949219 cites W2032822819 @default.
• W2894949219 cites W2034661665 @default.
• W2894949219 cites W2035198869 @default.
• W2894949219 cites W2035775191 @default.
• W2894949219 cites W2037274076 @default.
• W2894949219 cites W2038409007 @default.
• W2894949219 cites W2039207179 @default.
• W2894949219 cites W2039576936 @default.
• W2894949219 cites W2040789070 @default.
• W2894949219 cites W2042642277 @default.
• W2894949219 cites W2043687273 @default.
• W2894949219 cites W2045290631 @default.
• W2894949219 cites W2047057549 @default.
• W2894949219 cites W2047578651 @default.
• W2894949219 cites W2053263653 @default.
• W2894949219 cites W2053340574 @default.
• W2894949219 cites W2053737058 @default.
• W2894949219 cites W2055179768 @default.
• W2894949219 cites W2056174483 @default.
• W2894949219 cites W2056418256 @default.
• W2894949219 cites W2056982091 @default.
• W2894949219 cites W2059280113 @default.
• W2894949219 cites W2059437703 @default.
• W2894949219 cites W2059475071 @default.
• W2894949219 cites W2061165996 @default.
• W2894949219 cites W2061376698 @default.
• W2894949219 cites W2062027151 @default.
• W2894949219 cites W2067918790 @default.
• W2894949219 cites W2069166877 @default.

• next