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- W2894951265 abstract "TRPV5 (transient receptor potential vanilloid 5) is a unique calcium-selective TRP channel essential for calcium homeostasis. Unlike other TRPV channels, TRPV5 and its close homolog, TRPV6, do not exhibit thermosensitivity or ligand-dependent activation but are constitutively open at physiological membrane potentials and modulated by calmodulin (CaM) in a calcium-dependent manner. Here we report high-resolution electron cryomicroscopy structures of truncated and full-length TRPV5 in lipid nanodiscs, as well as of a TRPV5 W583A mutant and TRPV5 in complex with CaM. These structures highlight the mechanism of calcium regulation and reveal a flexible stoichiometry of CaM binding to TRPV5." @default.
- W2894951265 created "2018-10-12" @default.
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- W2894951265 date "2019-04-11" @default.
- W2894951265 modified "2023-10-18" @default.
- W2894951265 title "Structural insight into TRPV5 channel function and modulation" @default.
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- W2894951265 doi "https://doi.org/10.1073/pnas.1820323116" @default.
- W2894951265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6500171" @default.
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