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• W2894952151 abstract "The present study reported the preparation of a novel mutual prodrug containing meso-tetra (m-hydroxy phenyl) chlorin (m-THPC), PEG and folate. The folate receptor (FR) targeting compound is a water-soluble chemical incorporating a hydrophilic PEG spacer unit and a reducible selfimmolative disulfide-based linker system between the FR-targeting ligand and the chlorin. The m- THPC-s-s-PEG-Folate was proved to release the parent drug and exhibited significant targeting effects on HeLa cells. In addition, the redox-responsive folate targeting photosensitizer m-THPC-s-s-PEG-Folate showed slightly higher phototoxicity than m-THPC-PEG-Folate for HeLa cells." @default.
• W2894952151 created "2018-10-12" @default.
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• W2894952151 date "2019-02-11" @default.
• W2894952151 modified "2023-10-14" @default.
• W2894952151 title "Design, Synthesis, and Biological Activity of Releasable m-THPC-PEGfolate Conjugate Using a Disulfide-containing Linker" @default.
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• W2894952151 doi "https://doi.org/10.2174/1570178615666181003124619" @default.
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