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- W2894952304 abstract "Introduction: The influence of the location (head, body, tail) of pancreatic ductal adenocarcinoma (PDAC) on tumor stage, treatment and survival is unclear and investigated sporadically. Methods: Adult patients with PDAC (all stages) diagnosed between 2005-2015 from the population-based Netherlands Cancer Registry were included. Multivariable logistic and Cox regression analyses were used to determine independent influence of tumor location on the likelihood of receiving treatment and survival, respectively. Results: Among 19,098 included patients, locations were 13,502 (71%) head, 2,435 (13%) body and 3,161 (16%) tail. Differences were found regarding tumor stage (M1: head 42%, body 69%, tail 84%, p< 0.001), size (>4 cm: head 21%, body 40%, tail 51%, p< 0.001) and resectability (resected: head 18%, body 5%, tail 7%, p< 0.001), see Table 1. Median overall survival after resection was 16.8, 15.0 and 17.3 months for location head, body and tail, respectively (p=0.156). In multivariable analyses, after adjustment for tumor and treatment characteristics, overall survival was similar for (non-)resected M0 subgroups, but was lower for M1 patients with body or tail cancer compared to head cancer (adjusted HR 1.13, 95% CI 1.07-1.19 and 1.25, 95% CI 1.19-1.31, respectively). Conclusion: Cancers detected in the pancreatic body or tail are less common, larger, more often metastasized and less often resectable than pancreatic head cancers. If resected, however, survival was similar. Only in patients with metastasized disease, survival of patients with body or tail cancer was significantly worse than of patients with a head tumor." @default.
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- W2894952304 date "2018-09-01" @default.
- W2894952304 modified "2023-10-13" @default.
- W2894952304 title "Influence of the location (head, body, tail) of pancreatic ductal adenocarcinoma on tumor stage, treatment and survival: population-based analysis" @default.
- W2894952304 doi "https://doi.org/10.1016/j.hpb.2018.06.2044" @default.
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