FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894955090> ?p ?o ?g. }

• W2894955090 abstract "Abstract Cancer cells balance with the equilibrium of cell death and growth to expand and metastasize. The activity of mammalian sterile20-like kinases MST1/2 has been linked to apoptosis and tumor suppression via YAP/Hippo pathway dependent and independent mechanisms. With a kinase substrate screen we identified here MST1 and MST2 among the top substrates for fibroblast growth factor receptor 4 (FGFR4). In COS-1 cells, MST1 was phosphorylated at Y433 residue in an FGFR4 kinase activity-dependent manner, as assessed by mass spectrometry. Blockade of this phosphorylation by Y433F mutation induced MST1 activation, as reflected by increased autophosphorylation at T183 in FGFR4 overexpressing MDA-MB-231 cells. Importantly, the specific short-term inhibition or knockdown of FGFR4 also led to MST1/2 activation in conjunction with induction of MST1/2-dependent apoptosis in an endogenous model of HER2 + breast cancer cells. Moreover, FGFR4 knockdown increased the level of active nuclear MST1 coincidentally with cell polarization and membrane-association of YAP in three-dimensional breast cancer cell spheres. Consistently, FGFR4 overexpression correlated with reduced Hippo pathway-mediated, nuclear translocation-inhibiting YAP phosphorylation, and abysmal HER2 + breast carcinoma patient outcome in TCGA cohort. Our results reveal a novel mechanism for FGFR4 oncogenic activity via suppression of the stress-associated MST1/2-dependent apoptosis machinery in the tumor cells with prominent HER/ERBB signaling driven proliferation." @default.
• W2894955090 created "2018-10-12" @default.
• W2894955090 creator A5018320157 @default.
• W2894955090 creator A5057100162 @default.
• W2894955090 creator A5061046234 @default.
• W2894955090 creator A5073258092 @default.
• W2894955090 creator A5075159309 @default.
• W2894955090 creator A5077586204 @default.
• W2894955090 creator A5084314166 @default.
• W2894955090 creator A5085029945 @default.
• W2894955090 creator A5088559880 @default.
• W2894955090 creator A5089447588 @default.
• W2894955090 date "2018-10-02" @default.
• W2894955090 modified "2023-10-07" @default.
• W2894955090 title "FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis" @default.
• W2894955090 cites W1494988280 @default.
• W2894955090 cites W1963927300 @default.
• W2894955090 cites W1968521818 @default.
• W2894955090 cites W1968910405 @default.
• W2894955090 cites W1973757865 @default.
• W2894955090 cites W1974762803 @default.
• W2894955090 cites W1983886177 @default.
• W2894955090 cites W1993450230 @default.
• W2894955090 cites W1993926535 @default.
• W2894955090 cites W1994930469 @default.
• W2894955090 cites W1996690536 @default.
• W2894955090 cites W2003856466 @default.
• W2894955090 cites W2015136689 @default.
• W2894955090 cites W2016672123 @default.
• W2894955090 cites W2023471348 @default.
• W2894955090 cites W2028415754 @default.
• W2894955090 cites W2032853143 @default.
• W2894955090 cites W2044906650 @default.
• W2894955090 cites W2052623429 @default.
• W2894955090 cites W2060955824 @default.
• W2894955090 cites W2067151543 @default.
• W2894955090 cites W2072372914 @default.
• W2894955090 cites W2076943958 @default.
• W2894955090 cites W2078027095 @default.
• W2894955090 cites W2086892981 @default.
• W2894955090 cites W2091605046 @default.
• W2894955090 cites W2092128105 @default.
• W2894955090 cites W2094141392 @default.
• W2894955090 cites W2096283457 @default.
• W2894955090 cites W2102650364 @default.
• W2894955090 cites W2105047045 @default.
• W2894955090 cites W2107444537 @default.
• W2894955090 cites W2114843025 @default.
• W2894955090 cites W2115163495 @default.
• W2894955090 cites W2120646148 @default.
• W2894955090 cites W2129963340 @default.
• W2894955090 cites W2132163449 @default.
• W2894955090 cites W2132619562 @default.
• W2894955090 cites W2149441684 @default.
• W2894955090 cites W2155185697 @default.
• W2894955090 cites W2156542078 @default.
• W2894955090 cites W2164356111 @default.
• W2894955090 cites W2197268795 @default.
• W2894955090 cites W2206135107 @default.
• W2894955090 cites W2217321911 @default.
• W2894955090 cites W2221464277 @default.
• W2894955090 cites W2223413920 @default.
• W2894955090 cites W2291693837 @default.
• W2894955090 cites W2325375737 @default.
• W2894955090 cites W2426003472 @default.
• W2894955090 cites W2519289960 @default.
• W2894955090 cites W2595713273 @default.
• W2894955090 cites W2598066872 @default.
• W2894955090 cites W2610620780 @default.
• W2894955090 doi "https://doi.org/10.1101/431783" @default.
• W2894955090 hasPublicationYear "2018" @default.
• W2894955090 type Work @default.
• W2894955090 sameAs 2894955090 @default.
• W2894955090 citedByCount "0" @default.
• W2894955090 crossrefType "posted-content" @default.
• W2894955090 hasAuthorship W2894955090A5018320157 @default.
• W2894955090 hasAuthorship W2894955090A5057100162 @default.
• W2894955090 hasAuthorship W2894955090A5061046234 @default.
• W2894955090 hasAuthorship W2894955090A5073258092 @default.
• W2894955090 hasAuthorship W2894955090A5075159309 @default.
• W2894955090 hasAuthorship W2894955090A5077586204 @default.
• W2894955090 hasAuthorship W2894955090A5084314166 @default.
• W2894955090 hasAuthorship W2894955090A5085029945 @default.
• W2894955090 hasAuthorship W2894955090A5088559880 @default.
• W2894955090 hasAuthorship W2894955090A5089447588 @default.
• W2894955090 hasBestOaLocation W28949550901 @default.
• W2894955090 hasConcept C11960822 @default.
• W2894955090 hasConcept C121608353 @default.
• W2894955090 hasConcept C126322002 @default.
• W2894955090 hasConcept C150109051 @default.
• W2894955090 hasConcept C170493617 @default.
• W2894955090 hasConcept C172512520 @default.
• W2894955090 hasConcept C184235292 @default.
• W2894955090 hasConcept C185592680 @default.
• W2894955090 hasConcept C190283241 @default.
• W2894955090 hasConcept C502942594 @default.
• W2894955090 hasConcept C55493867 @default.
• W2894955090 hasConcept C66400584 @default.
• W2894955090 hasConcept C71924100 @default.
• W2894955090 hasConcept C74373430 @default.

• next